Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat

Autores
Scollon, Edward J.; Starr, James M.; Crofton, Kevin M.; Wolansky, Marcelo Javier; DeVito, Michael J.; Hughes, Michael F.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The potential for human exposure to pyrethroid pesticides has prompted pharmacodynamic and pharmacokinetic research to better characterize risk. This work tested the hypothesis that blood and brain concentrations of the pyrethroid bifenthrin are predictive of neurotoxic effects. Adult male Long Evans rats received a single oral dose of bifenthrin dissolved in corn oil. Using figure-eight mazes, motor activity was measured for 1h at 4- and 7-h following exposure to bifenthrin (0-16mg/kg or 0-9mg/kg, respectively; n=4-8/group). Whole blood and brains were collected immediately following motor activity assays. Bifenthrin concentrations in blood and brain were quantified using HPLC/MS/MS. Bifenthrin exposure decreased motor activity from 20% to 70% in a dose-dependent manner at both time points. The relationship between motor activity data and administered dose, and blood and brain bifenthrin concentrations were described using a sigmoidal E max model. The relationships between motor activity and administered dose or blood concentrations were different between the 4- and 7-h time points. The relationship between motor activity and brain concentration was not significantly different between the two time points. These data suggest that momentary brain concentration of bifenthrin may be a more precise dose metric for predicting behavioral effects because the relationship between brain concentration and locomotor activity is independent of the time of exposure.
Fil: Scollon, Edward J.. National Health And Environmental Effects Research Laboratory; Estados Unidos
Fil: Starr, James M.. United States Environmental Protection Agency; Estados Unidos
Fil: Crofton, Kevin M.. National Health And Environmental Effects Research Laboratory; Estados Unidos
Fil: Wolansky, Marcelo Javier. National Research Council; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: DeVito, Michael J.. National Health And Environmental Effects Research Laboratory; Estados Unidos
Fil: Hughes, Michael F.. National Health And Environmental Effects Research Laboratory; Estados Unidos
Materia
BIFENTHRIN
BLOOD CONCENTRATIONS
BRAIN CONCENTRATIONS
MOTOR ACTIVITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95882
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/95882
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the ratScollon, Edward J.Starr, James M.Crofton, Kevin M.Wolansky, Marcelo JavierDeVito, Michael J.Hughes, Michael F.BIFENTHRINBLOOD CONCENTRATIONSBRAIN CONCENTRATIONSMOTOR ACTIVITYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The potential for human exposure to pyrethroid pesticides has prompted pharmacodynamic and pharmacokinetic research to better characterize risk. This work tested the hypothesis that blood and brain concentrations of the pyrethroid bifenthrin are predictive of neurotoxic effects. Adult male Long Evans rats received a single oral dose of bifenthrin dissolved in corn oil. Using figure-eight mazes, motor activity was measured for 1h at 4- and 7-h following exposure to bifenthrin (0-16mg/kg or 0-9mg/kg, respectively; n=4-8/group). Whole blood and brains were collected immediately following motor activity assays. Bifenthrin concentrations in blood and brain were quantified using HPLC/MS/MS. Bifenthrin exposure decreased motor activity from 20% to 70% in a dose-dependent manner at both time points. The relationship between motor activity data and administered dose, and blood and brain bifenthrin concentrations were described using a sigmoidal E max model. The relationships between motor activity and administered dose or blood concentrations were different between the 4- and 7-h time points. The relationship between motor activity and brain concentration was not significantly different between the two time points. These data suggest that momentary brain concentration of bifenthrin may be a more precise dose metric for predicting behavioral effects because the relationship between brain concentration and locomotor activity is independent of the time of exposure.Fil: Scollon, Edward J.. National Health And Environmental Effects Research Laboratory; Estados UnidosFil: Starr, James M.. United States Environmental Protection Agency; Estados UnidosFil: Crofton, Kevin M.. National Health And Environmental Effects Research Laboratory; Estados UnidosFil: Wolansky, Marcelo Javier. National Research Council; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: DeVito, Michael J.. National Health And Environmental Effects Research Laboratory; Estados UnidosFil: Hughes, Michael F.. National Health And Environmental Effects Research Laboratory; Estados UnidosElsevier Ireland2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/95882Scollon, Edward J.; Starr, James M.; Crofton, Kevin M.; Wolansky, Marcelo Javier; DeVito, Michael J.; et al.; Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat; Elsevier Ireland; Toxicology; 290; 1; 11-2011; 1-60300-483XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0300483X11002939info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682199/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tox.2011.08.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:45Zoai:ri.conicet.gov.ar:11336/95882instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:45.432CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
title Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
spellingShingle Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
Scollon, Edward J.
BIFENTHRIN
BLOOD CONCENTRATIONS
BRAIN CONCENTRATIONS
MOTOR ACTIVITY
title_short Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
title_full Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
title_fullStr Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
title_full_unstemmed Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
title_sort Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat
dc.creator.none.fl_str_mv Scollon, Edward J.
Starr, James M.
Crofton, Kevin M.
Wolansky, Marcelo Javier
DeVito, Michael J.
Hughes, Michael F.
author Scollon, Edward J.
author_facet Scollon, Edward J.
Starr, James M.
Crofton, Kevin M.
Wolansky, Marcelo Javier
DeVito, Michael J.
Hughes, Michael F.
author_role author
author2 Starr, James M.
Crofton, Kevin M.
Wolansky, Marcelo Javier
DeVito, Michael J.
Hughes, Michael F.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BIFENTHRIN
BLOOD CONCENTRATIONS
BRAIN CONCENTRATIONS
MOTOR ACTIVITY
topic BIFENTHRIN
BLOOD CONCENTRATIONS
BRAIN CONCENTRATIONS
MOTOR ACTIVITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The potential for human exposure to pyrethroid pesticides has prompted pharmacodynamic and pharmacokinetic research to better characterize risk. This work tested the hypothesis that blood and brain concentrations of the pyrethroid bifenthrin are predictive of neurotoxic effects. Adult male Long Evans rats received a single oral dose of bifenthrin dissolved in corn oil. Using figure-eight mazes, motor activity was measured for 1h at 4- and 7-h following exposure to bifenthrin (0-16mg/kg or 0-9mg/kg, respectively; n=4-8/group). Whole blood and brains were collected immediately following motor activity assays. Bifenthrin concentrations in blood and brain were quantified using HPLC/MS/MS. Bifenthrin exposure decreased motor activity from 20% to 70% in a dose-dependent manner at both time points. The relationship between motor activity data and administered dose, and blood and brain bifenthrin concentrations were described using a sigmoidal E max model. The relationships between motor activity and administered dose or blood concentrations were different between the 4- and 7-h time points. The relationship between motor activity and brain concentration was not significantly different between the two time points. These data suggest that momentary brain concentration of bifenthrin may be a more precise dose metric for predicting behavioral effects because the relationship between brain concentration and locomotor activity is independent of the time of exposure.
Fil: Scollon, Edward J.. National Health And Environmental Effects Research Laboratory; Estados Unidos
Fil: Starr, James M.. United States Environmental Protection Agency; Estados Unidos
Fil: Crofton, Kevin M.. National Health And Environmental Effects Research Laboratory; Estados Unidos
Fil: Wolansky, Marcelo Javier. National Research Council; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: DeVito, Michael J.. National Health And Environmental Effects Research Laboratory; Estados Unidos
Fil: Hughes, Michael F.. National Health And Environmental Effects Research Laboratory; Estados Unidos
description The potential for human exposure to pyrethroid pesticides has prompted pharmacodynamic and pharmacokinetic research to better characterize risk. This work tested the hypothesis that blood and brain concentrations of the pyrethroid bifenthrin are predictive of neurotoxic effects. Adult male Long Evans rats received a single oral dose of bifenthrin dissolved in corn oil. Using figure-eight mazes, motor activity was measured for 1h at 4- and 7-h following exposure to bifenthrin (0-16mg/kg or 0-9mg/kg, respectively; n=4-8/group). Whole blood and brains were collected immediately following motor activity assays. Bifenthrin concentrations in blood and brain were quantified using HPLC/MS/MS. Bifenthrin exposure decreased motor activity from 20% to 70% in a dose-dependent manner at both time points. The relationship between motor activity data and administered dose, and blood and brain bifenthrin concentrations were described using a sigmoidal E max model. The relationships between motor activity and administered dose or blood concentrations were different between the 4- and 7-h time points. The relationship between motor activity and brain concentration was not significantly different between the two time points. These data suggest that momentary brain concentration of bifenthrin may be a more precise dose metric for predicting behavioral effects because the relationship between brain concentration and locomotor activity is independent of the time of exposure.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95882
Scollon, Edward J.; Starr, James M.; Crofton, Kevin M.; Wolansky, Marcelo Javier; DeVito, Michael J.; et al.; Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat; Elsevier Ireland; Toxicology; 290; 1; 11-2011; 1-6
0300-483X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95882
identifier_str_mv Scollon, Edward J.; Starr, James M.; Crofton, Kevin M.; Wolansky, Marcelo Javier; DeVito, Michael J.; et al.; Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat; Elsevier Ireland; Toxicology; 290; 1; 11-2011; 1-6
0300-483X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0300483X11002939
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682199/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tox.2011.08.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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