Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation

Autores
Mendez Huergo, Santiago Patricio; Maller, Sebastian Matias; Farez, Mauricio Franco; Mariño, Karina Valeria; Correale, Jorge; Rabinovich, Gabriel Adrián
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multiple sclerosis (MS) is a progressive degenerative disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal loss. While the majority of MS patients experience relapsing-remitting symptoms followed by a secondary progressive phase, about 10–15% patients exhibit a primary progressive disease involving continuous progression from its onset. Here we review the role of lectin–glycan recognition systems, including those concerning siglecs, C-type lectins and galectins in the pathogenesis of MS and experimental autoimmune encephalomyelitis. Particularly, we will focus on the role of galectins in the fate of T cells, dendritic cells and CNS cell populations. Understanding the regulatory circuits governed by lectin–glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS.
Fil: Mendez Huergo, Santiago Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Maller, Sebastian Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Farez, Mauricio Franco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Correale, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Materia
Multiple Sclerosis
Glycans
Siglecs
Clr
Galectins
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6292
Acceder
id CONICETDig_75d812c0a33efdad8196a8c763ba48e9
oai_identifier_str oai:ri.conicet.gov.ar:11336/6292
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammationMendez Huergo, Santiago PatricioMaller, Sebastian MatiasFarez, Mauricio FrancoMariño, Karina ValeriaCorreale, JorgeRabinovich, Gabriel AdriánMultiple SclerosisGlycansSiglecsClrGalectinshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Multiple sclerosis (MS) is a progressive degenerative disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal loss. While the majority of MS patients experience relapsing-remitting symptoms followed by a secondary progressive phase, about 10–15% patients exhibit a primary progressive disease involving continuous progression from its onset. Here we review the role of lectin–glycan recognition systems, including those concerning siglecs, C-type lectins and galectins in the pathogenesis of MS and experimental autoimmune encephalomyelitis. Particularly, we will focus on the role of galectins in the fate of T cells, dendritic cells and CNS cell populations. Understanding the regulatory circuits governed by lectin–glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS.Fil: Mendez Huergo, Santiago Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Maller, Sebastian Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Farez, Mauricio Franco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Correale, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaElsevier2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6292Mendez Huergo, Santiago Patricio; Maller, Sebastian Matias; Farez, Mauricio Franco; Mariño, Karina Valeria; Correale, Jorge; et al.; Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation; Elsevier; Cytokine & Growth Factor Reviews; 25; 3; 3-2014; 247-2551359-61011879-0305enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cytogfr.2014.02.003info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1359610114000203info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:25Zoai:ri.conicet.gov.ar:11336/6292instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:25.313CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
title Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
spellingShingle Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
Mendez Huergo, Santiago Patricio
Multiple Sclerosis
Glycans
Siglecs
Clr
Galectins
title_short Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
title_full Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
title_fullStr Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
title_full_unstemmed Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
title_sort Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
dc.creator.none.fl_str_mv Mendez Huergo, Santiago Patricio
Maller, Sebastian Matias
Farez, Mauricio Franco
Mariño, Karina Valeria
Correale, Jorge
Rabinovich, Gabriel Adrián
author Mendez Huergo, Santiago Patricio
author_facet Mendez Huergo, Santiago Patricio
Maller, Sebastian Matias
Farez, Mauricio Franco
Mariño, Karina Valeria
Correale, Jorge
Rabinovich, Gabriel Adrián
author_role author
author2 Maller, Sebastian Matias
Farez, Mauricio Franco
Mariño, Karina Valeria
Correale, Jorge
Rabinovich, Gabriel Adrián
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Multiple Sclerosis
Glycans
Siglecs
Clr
Galectins
topic Multiple Sclerosis
Glycans
Siglecs
Clr
Galectins
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Multiple sclerosis (MS) is a progressive degenerative disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal loss. While the majority of MS patients experience relapsing-remitting symptoms followed by a secondary progressive phase, about 10–15% patients exhibit a primary progressive disease involving continuous progression from its onset. Here we review the role of lectin–glycan recognition systems, including those concerning siglecs, C-type lectins and galectins in the pathogenesis of MS and experimental autoimmune encephalomyelitis. Particularly, we will focus on the role of galectins in the fate of T cells, dendritic cells and CNS cell populations. Understanding the regulatory circuits governed by lectin–glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS.
Fil: Mendez Huergo, Santiago Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Maller, Sebastian Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Farez, Mauricio Franco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Correale, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
description Multiple sclerosis (MS) is a progressive degenerative disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal loss. While the majority of MS patients experience relapsing-remitting symptoms followed by a secondary progressive phase, about 10–15% patients exhibit a primary progressive disease involving continuous progression from its onset. Here we review the role of lectin–glycan recognition systems, including those concerning siglecs, C-type lectins and galectins in the pathogenesis of MS and experimental autoimmune encephalomyelitis. Particularly, we will focus on the role of galectins in the fate of T cells, dendritic cells and CNS cell populations. Understanding the regulatory circuits governed by lectin–glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6292
Mendez Huergo, Santiago Patricio; Maller, Sebastian Matias; Farez, Mauricio Franco; Mariño, Karina Valeria; Correale, Jorge; et al.; Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation; Elsevier; Cytokine & Growth Factor Reviews; 25; 3; 3-2014; 247-255
1359-6101
1879-0305
url http://hdl.handle.net/11336/6292
identifier_str_mv Mendez Huergo, Santiago Patricio; Maller, Sebastian Matias; Farez, Mauricio Franco; Mariño, Karina Valeria; Correale, Jorge; et al.; Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation; Elsevier; Cytokine & Growth Factor Reviews; 25; 3; 3-2014; 247-255
1359-6101
1879-0305
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cytogfr.2014.02.003
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1359610114000203
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268793149063168
score 13.13397

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