Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)

Autores
Blois, Sandra M.; Verlohren, Stefan; Wu, Gang; Clark, Gary; Dell, Anne; Haslam, Stuart M.; Barrientos, Gabriela Laura
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
Fil: Blois, Sandra M.. Experimental and Clinical Research Center; Alemania. Charité-Universitätsmedizin Berlin; Alemania. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Verlohren, Stefan. Charité-Universitätsmedizin Berlin; Alemania
Fil: Wu, Gang. Imperial College London; Reino Unido
Fil: Clark, Gary. University of Missouri; Estados Unidos
Fil: Dell, Anne. Imperial College London; Reino Unido
Fil: Haslam, Stuart M.. Imperial College London; Reino Unido
Fil: Barrientos, Gabriela Laura. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
GALECTINS
GLYCANS
MICROBIAL INFECTIONS
PRETERM BIRTH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/170102
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/170102
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)Blois, Sandra M.Verlohren, StefanWu, GangClark, GaryDell, AnneHaslam, Stuart M.Barrientos, Gabriela LauraGALECTINSGLYCANSMICROBIAL INFECTIONSPRETERM BIRTHhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.Fil: Blois, Sandra M.. Experimental and Clinical Research Center; Alemania. Charité-Universitätsmedizin Berlin; Alemania. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Verlohren, Stefan. Charité-Universitätsmedizin Berlin; AlemaniaFil: Wu, Gang. Imperial College London; Reino UnidoFil: Clark, Gary. University of Missouri; Estados UnidosFil: Dell, Anne. Imperial College London; Reino UnidoFil: Haslam, Stuart M.. Imperial College London; Reino UnidoFil: Barrientos, Gabriela Laura. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSpringer2020-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170102Blois, Sandra M.; Verlohren, Stefan; Wu, Gang; Clark, Gary; Dell, Anne; et al.; Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB); Springer; Seminars in Immunopathology; 42; 4; 8-2020; 469-4861863-22971863-2300CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00281-020-00801-4info:eu-repo/semantics/altIdentifier/doi/10.1007/s00281-020-00801-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:01Zoai:ri.conicet.gov.ar:11336/170102instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:01.728CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
title Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
spellingShingle Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
Blois, Sandra M.
GALECTINS
GLYCANS
MICROBIAL INFECTIONS
PRETERM BIRTH
title_short Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
title_full Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
title_fullStr Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
title_full_unstemmed Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
title_sort Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
dc.creator.none.fl_str_mv Blois, Sandra M.
Verlohren, Stefan
Wu, Gang
Clark, Gary
Dell, Anne
Haslam, Stuart M.
Barrientos, Gabriela Laura
author Blois, Sandra M.
author_facet Blois, Sandra M.
Verlohren, Stefan
Wu, Gang
Clark, Gary
Dell, Anne
Haslam, Stuart M.
Barrientos, Gabriela Laura
author_role author
author2 Verlohren, Stefan
Wu, Gang
Clark, Gary
Dell, Anne
Haslam, Stuart M.
Barrientos, Gabriela Laura
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv GALECTINS
GLYCANS
MICROBIAL INFECTIONS
PRETERM BIRTH
topic GALECTINS
GLYCANS
MICROBIAL INFECTIONS
PRETERM BIRTH
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
Fil: Blois, Sandra M.. Experimental and Clinical Research Center; Alemania. Charité-Universitätsmedizin Berlin; Alemania. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Verlohren, Stefan. Charité-Universitätsmedizin Berlin; Alemania
Fil: Wu, Gang. Imperial College London; Reino Unido
Fil: Clark, Gary. University of Missouri; Estados Unidos
Fil: Dell, Anne. Imperial College London; Reino Unido
Fil: Haslam, Stuart M.. Imperial College London; Reino Unido
Fil: Barrientos, Gabriela Laura. Hospital Aleman. Laboratorio de Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
publishDate 2020
dc.date.none.fl_str_mv 2020-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/170102
Blois, Sandra M.; Verlohren, Stefan; Wu, Gang; Clark, Gary; Dell, Anne; et al.; Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB); Springer; Seminars in Immunopathology; 42; 4; 8-2020; 469-486
1863-2297
1863-2300
CONICET Digital
CONICET
url http://hdl.handle.net/11336/170102
identifier_str_mv Blois, Sandra M.; Verlohren, Stefan; Wu, Gang; Clark, Gary; Dell, Anne; et al.; Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB); Springer; Seminars in Immunopathology; 42; 4; 8-2020; 469-486
1863-2297
1863-2300
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00281-020-00801-4
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00281-020-00801-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270066346819584
score 13.13397

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