Untangling galectin-driven regulatory circuits in autoimmune inflammation

Autores
Toscano, Marta Alicia; Martínez Allo, Verónica Candela; Cutine, Anabela María; Rabinovich, Gabriel Adrián; Mariño, Karina Valeria
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although significant progress has been made in understanding the mechanisms implicated in the pathogenesis and resolution of autoimmune inflammation, studies aimed at identifying mediators of these pathways are necessary for developing more selective therapies. Galectins, a family of glycan-binding proteins, play central roles in immune cell homeostasis. Whereas some members of this family trigger regulatory programs that promote resolution of inflammation, others contribute to perpetuate autoimmune processes. Here we discuss the roles of endogenous galectins and their specific glycosylated ligands in shaping autoimmune responses by fueling, extinguishing or re-wiring immune circuits. Understanding the relevance of galectin-glycan interactions in autoimmune inflammation could help uncover novel pathways of tolerance breakdown, define molecular signatures for patient stratification and therapy responses and open new avenues for immune intervention.
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Martínez Allo, Verónica Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Cutine, Anabela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
AUTOIMMUNITY
CHRONIC INFLAMMATION
GALECTINS
GLYCANS
IMMUNOREGULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/89500
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Untangling galectin-driven regulatory circuits in autoimmune inflammationToscano, Marta AliciaMartínez Allo, Verónica CandelaCutine, Anabela MaríaRabinovich, Gabriel AdriánMariño, Karina ValeriaAUTOIMMUNITYCHRONIC INFLAMMATIONGALECTINSGLYCANSIMMUNOREGULATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Although significant progress has been made in understanding the mechanisms implicated in the pathogenesis and resolution of autoimmune inflammation, studies aimed at identifying mediators of these pathways are necessary for developing more selective therapies. Galectins, a family of glycan-binding proteins, play central roles in immune cell homeostasis. Whereas some members of this family trigger regulatory programs that promote resolution of inflammation, others contribute to perpetuate autoimmune processes. Here we discuss the roles of endogenous galectins and their specific glycosylated ligands in shaping autoimmune responses by fueling, extinguishing or re-wiring immune circuits. Understanding the relevance of galectin-glycan interactions in autoimmune inflammation could help uncover novel pathways of tolerance breakdown, define molecular signatures for patient stratification and therapy responses and open new avenues for immune intervention.Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Martínez Allo, Verónica Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Cutine, Anabela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaElsevier2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89500Toscano, Marta Alicia; Martínez Allo, Verónica Candela; Cutine, Anabela María; Rabinovich, Gabriel Adrián; Mariño, Karina Valeria; Untangling galectin-driven regulatory circuits in autoimmune inflammation; Elsevier; Trends In Molecular Medicine; 24; 4; 4-2018; 348-3631471-4914CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30032-7info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molmed.2018.02.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:05Zoai:ri.conicet.gov.ar:11336/89500instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:05.911CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Untangling galectin-driven regulatory circuits in autoimmune inflammation
title Untangling galectin-driven regulatory circuits in autoimmune inflammation
spellingShingle Untangling galectin-driven regulatory circuits in autoimmune inflammation
Toscano, Marta Alicia
AUTOIMMUNITY
CHRONIC INFLAMMATION
GALECTINS
GLYCANS
IMMUNOREGULATION
title_short Untangling galectin-driven regulatory circuits in autoimmune inflammation
title_full Untangling galectin-driven regulatory circuits in autoimmune inflammation
title_fullStr Untangling galectin-driven regulatory circuits in autoimmune inflammation
title_full_unstemmed Untangling galectin-driven regulatory circuits in autoimmune inflammation
title_sort Untangling galectin-driven regulatory circuits in autoimmune inflammation
dc.creator.none.fl_str_mv Toscano, Marta Alicia
Martínez Allo, Verónica Candela
Cutine, Anabela María
Rabinovich, Gabriel Adrián
Mariño, Karina Valeria
author Toscano, Marta Alicia
author_facet Toscano, Marta Alicia
Martínez Allo, Verónica Candela
Cutine, Anabela María
Rabinovich, Gabriel Adrián
Mariño, Karina Valeria
author_role author
author2 Martínez Allo, Verónica Candela
Cutine, Anabela María
Rabinovich, Gabriel Adrián
Mariño, Karina Valeria
author2_role author
author
author
author
dc.subject.none.fl_str_mv AUTOIMMUNITY
CHRONIC INFLAMMATION
GALECTINS
GLYCANS
IMMUNOREGULATION
topic AUTOIMMUNITY
CHRONIC INFLAMMATION
GALECTINS
GLYCANS
IMMUNOREGULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although significant progress has been made in understanding the mechanisms implicated in the pathogenesis and resolution of autoimmune inflammation, studies aimed at identifying mediators of these pathways are necessary for developing more selective therapies. Galectins, a family of glycan-binding proteins, play central roles in immune cell homeostasis. Whereas some members of this family trigger regulatory programs that promote resolution of inflammation, others contribute to perpetuate autoimmune processes. Here we discuss the roles of endogenous galectins and their specific glycosylated ligands in shaping autoimmune responses by fueling, extinguishing or re-wiring immune circuits. Understanding the relevance of galectin-glycan interactions in autoimmune inflammation could help uncover novel pathways of tolerance breakdown, define molecular signatures for patient stratification and therapy responses and open new avenues for immune intervention.
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Martínez Allo, Verónica Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Cutine, Anabela María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Although significant progress has been made in understanding the mechanisms implicated in the pathogenesis and resolution of autoimmune inflammation, studies aimed at identifying mediators of these pathways are necessary for developing more selective therapies. Galectins, a family of glycan-binding proteins, play central roles in immune cell homeostasis. Whereas some members of this family trigger regulatory programs that promote resolution of inflammation, others contribute to perpetuate autoimmune processes. Here we discuss the roles of endogenous galectins and their specific glycosylated ligands in shaping autoimmune responses by fueling, extinguishing or re-wiring immune circuits. Understanding the relevance of galectin-glycan interactions in autoimmune inflammation could help uncover novel pathways of tolerance breakdown, define molecular signatures for patient stratification and therapy responses and open new avenues for immune intervention.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/89500
Toscano, Marta Alicia; Martínez Allo, Verónica Candela; Cutine, Anabela María; Rabinovich, Gabriel Adrián; Mariño, Karina Valeria; Untangling galectin-driven regulatory circuits in autoimmune inflammation; Elsevier; Trends In Molecular Medicine; 24; 4; 4-2018; 348-363
1471-4914
CONICET Digital
CONICET
url http://hdl.handle.net/11336/89500
identifier_str_mv Toscano, Marta Alicia; Martínez Allo, Verónica Candela; Cutine, Anabela María; Rabinovich, Gabriel Adrián; Mariño, Karina Valeria; Untangling galectin-driven regulatory circuits in autoimmune inflammation; Elsevier; Trends In Molecular Medicine; 24; 4; 4-2018; 348-363
1471-4914
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(18)30032-7
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molmed.2018.02.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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