Disrupted functional connectivity of the pain network in fibromyalgia

Autores
Cifre, Ignacio; Sitges, Carolina; Fraiman, Daniel; Muñoz, Miguel Ángel; Balenzuela, Pablo; González Roldán, Ana; Martínez Jauand, Mercedes; Birbaumer, Niels; Chialvo, Dante Renato; Montoya, Pedro
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen levelYdependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia ( p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values G .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values G .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values G .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values G .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r = j0.64, p = .003) and ACC (r = j0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggest- ing that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. Key words: fibromyalgia, chronic pain, resting state, functional connectivity, partial correlation analysis.
Fil: Cifre, Ignacio. No especifíca;
Fil: Sitges, Carolina. No especifíca;
Fil: Fraiman, Daniel. Universidad de San Andrés; Argentina
Fil: Muñoz, Miguel Ángel. No especifíca;
Fil: Balenzuela, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: González Roldán, Ana. No especifíca;
Fil: Martínez Jauand, Mercedes. No especifíca;
Fil: Birbaumer, Niels. No especifíca;
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Montoya, Pedro. No especifíca;
Materia
CHRONIC PAIN
FIBROMYALGIA
FUNCTIONAL CONNECTIVITY
PARTIAL CORRELATION ANALYSIS
RESTING STATE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/196757

id CONICETDig_75b19a24100229b42ee068cbd5f86b7a
oai_identifier_str oai:ri.conicet.gov.ar:11336/196757
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Disrupted functional connectivity of the pain network in fibromyalgiaCifre, IgnacioSitges, CarolinaFraiman, DanielMuñoz, Miguel ÁngelBalenzuela, PabloGonzález Roldán, AnaMartínez Jauand, MercedesBirbaumer, NielsChialvo, Dante RenatoMontoya, PedroCHRONIC PAINFIBROMYALGIAFUNCTIONAL CONNECTIVITYPARTIAL CORRELATION ANALYSISRESTING STATEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen levelYdependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia ( p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values G .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values G .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values G .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values G .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r = j0.64, p = .003) and ACC (r = j0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggest- ing that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. Key words: fibromyalgia, chronic pain, resting state, functional connectivity, partial correlation analysis.Fil: Cifre, Ignacio. No especifíca;Fil: Sitges, Carolina. No especifíca;Fil: Fraiman, Daniel. Universidad de San Andrés; ArgentinaFil: Muñoz, Miguel Ángel. No especifíca;Fil: Balenzuela, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: González Roldán, Ana. No especifíca;Fil: Martínez Jauand, Mercedes. No especifíca;Fil: Birbaumer, Niels. No especifíca;Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Montoya, Pedro. No especifíca;Lippincott Williams2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/196757Cifre, Ignacio; Sitges, Carolina; Fraiman, Daniel; Muñoz, Miguel Ángel; Balenzuela, Pablo; et al.; Disrupted functional connectivity of the pain network in fibromyalgia; Lippincott Williams; Psychosomatic Medicine; 74; 1; 1-2012; 55-620033-3174CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.psychosomaticmedicine.org/content/74/1/55.abstract?sid=5d532b28-9f6b-4cdc-8bda-ea4c52d90882info:eu-repo/semantics/altIdentifier/doi/10.1097/PSY.0b013e3182408f04info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:30Zoai:ri.conicet.gov.ar:11336/196757instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:31.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Disrupted functional connectivity of the pain network in fibromyalgia
title Disrupted functional connectivity of the pain network in fibromyalgia
spellingShingle Disrupted functional connectivity of the pain network in fibromyalgia
Cifre, Ignacio
CHRONIC PAIN
FIBROMYALGIA
FUNCTIONAL CONNECTIVITY
PARTIAL CORRELATION ANALYSIS
RESTING STATE
title_short Disrupted functional connectivity of the pain network in fibromyalgia
title_full Disrupted functional connectivity of the pain network in fibromyalgia
title_fullStr Disrupted functional connectivity of the pain network in fibromyalgia
title_full_unstemmed Disrupted functional connectivity of the pain network in fibromyalgia
title_sort Disrupted functional connectivity of the pain network in fibromyalgia
dc.creator.none.fl_str_mv Cifre, Ignacio
Sitges, Carolina
Fraiman, Daniel
Muñoz, Miguel Ángel
Balenzuela, Pablo
González Roldán, Ana
Martínez Jauand, Mercedes
Birbaumer, Niels
Chialvo, Dante Renato
Montoya, Pedro
author Cifre, Ignacio
author_facet Cifre, Ignacio
Sitges, Carolina
Fraiman, Daniel
Muñoz, Miguel Ángel
Balenzuela, Pablo
González Roldán, Ana
Martínez Jauand, Mercedes
Birbaumer, Niels
Chialvo, Dante Renato
Montoya, Pedro
author_role author
author2 Sitges, Carolina
Fraiman, Daniel
Muñoz, Miguel Ángel
Balenzuela, Pablo
González Roldán, Ana
Martínez Jauand, Mercedes
Birbaumer, Niels
Chialvo, Dante Renato
Montoya, Pedro
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHRONIC PAIN
FIBROMYALGIA
FUNCTIONAL CONNECTIVITY
PARTIAL CORRELATION ANALYSIS
RESTING STATE
topic CHRONIC PAIN
FIBROMYALGIA
FUNCTIONAL CONNECTIVITY
PARTIAL CORRELATION ANALYSIS
RESTING STATE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen levelYdependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia ( p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values G .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values G .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values G .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values G .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r = j0.64, p = .003) and ACC (r = j0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggest- ing that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. Key words: fibromyalgia, chronic pain, resting state, functional connectivity, partial correlation analysis.
Fil: Cifre, Ignacio. No especifíca;
Fil: Sitges, Carolina. No especifíca;
Fil: Fraiman, Daniel. Universidad de San Andrés; Argentina
Fil: Muñoz, Miguel Ángel. No especifíca;
Fil: Balenzuela, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: González Roldán, Ana. No especifíca;
Fil: Martínez Jauand, Mercedes. No especifíca;
Fil: Birbaumer, Niels. No especifíca;
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Montoya, Pedro. No especifíca;
description Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen levelYdependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia ( p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values G .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values G .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values G .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values G .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r = j0.64, p = .003) and ACC (r = j0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggest- ing that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. Key words: fibromyalgia, chronic pain, resting state, functional connectivity, partial correlation analysis.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/196757
Cifre, Ignacio; Sitges, Carolina; Fraiman, Daniel; Muñoz, Miguel Ángel; Balenzuela, Pablo; et al.; Disrupted functional connectivity of the pain network in fibromyalgia; Lippincott Williams; Psychosomatic Medicine; 74; 1; 1-2012; 55-62
0033-3174
CONICET Digital
CONICET
url http://hdl.handle.net/11336/196757
identifier_str_mv Cifre, Ignacio; Sitges, Carolina; Fraiman, Daniel; Muñoz, Miguel Ángel; Balenzuela, Pablo; et al.; Disrupted functional connectivity of the pain network in fibromyalgia; Lippincott Williams; Psychosomatic Medicine; 74; 1; 1-2012; 55-62
0033-3174
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.psychosomaticmedicine.org/content/74/1/55.abstract?sid=5d532b28-9f6b-4cdc-8bda-ea4c52d90882
info:eu-repo/semantics/altIdentifier/doi/10.1097/PSY.0b013e3182408f04
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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