Disrupted functional connectivity of the pain network in fibromyalgia
- Autores
- Cifre, Ignacio; Sitges, Carolina; Fraiman, Daniel; Muñoz, Miguel Ángel; Balenzuela, Pablo; González Roldán, Ana; Martínez Jauand, Mercedes; Birbaumer, Niels; Chialvo, Dante Renato; Montoya, Pedro
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen levelYdependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia ( p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values G .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values G .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values G .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values G .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r = j0.64, p = .003) and ACC (r = j0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggest- ing that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. Key words: fibromyalgia, chronic pain, resting state, functional connectivity, partial correlation analysis.
Fil: Cifre, Ignacio. No especifíca;
Fil: Sitges, Carolina. No especifíca;
Fil: Fraiman, Daniel. Universidad de San Andrés; Argentina
Fil: Muñoz, Miguel Ángel. No especifíca;
Fil: Balenzuela, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: González Roldán, Ana. No especifíca;
Fil: Martínez Jauand, Mercedes. No especifíca;
Fil: Birbaumer, Niels. No especifíca;
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Montoya, Pedro. No especifíca; - Materia
-
CHRONIC PAIN
FIBROMYALGIA
FUNCTIONAL CONNECTIVITY
PARTIAL CORRELATION ANALYSIS
RESTING STATE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/196757
Ver los metadatos del registro completo
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3498 |
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CONICET Digital (CONICET) |
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Disrupted functional connectivity of the pain network in fibromyalgiaCifre, IgnacioSitges, CarolinaFraiman, DanielMuñoz, Miguel ÁngelBalenzuela, PabloGonzález Roldán, AnaMartínez Jauand, MercedesBirbaumer, NielsChialvo, Dante RenatoMontoya, PedroCHRONIC PAINFIBROMYALGIAFUNCTIONAL CONNECTIVITYPARTIAL CORRELATION ANALYSISRESTING STATEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen levelYdependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia ( p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values G .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values G .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values G .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values G .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r = j0.64, p = .003) and ACC (r = j0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggest- ing that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. Key words: fibromyalgia, chronic pain, resting state, functional connectivity, partial correlation analysis.Fil: Cifre, Ignacio. No especifíca;Fil: Sitges, Carolina. No especifíca;Fil: Fraiman, Daniel. Universidad de San Andrés; ArgentinaFil: Muñoz, Miguel Ángel. No especifíca;Fil: Balenzuela, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: González Roldán, Ana. No especifíca;Fil: Martínez Jauand, Mercedes. No especifíca;Fil: Birbaumer, Niels. No especifíca;Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Montoya, Pedro. No especifíca;Lippincott Williams2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/196757Cifre, Ignacio; Sitges, Carolina; Fraiman, Daniel; Muñoz, Miguel Ángel; Balenzuela, Pablo; et al.; Disrupted functional connectivity of the pain network in fibromyalgia; Lippincott Williams; Psychosomatic Medicine; 74; 1; 1-2012; 55-620033-3174CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.psychosomaticmedicine.org/content/74/1/55.abstract?sid=5d532b28-9f6b-4cdc-8bda-ea4c52d90882info:eu-repo/semantics/altIdentifier/doi/10.1097/PSY.0b013e3182408f04info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:30Zoai:ri.conicet.gov.ar:11336/196757instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:31.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Disrupted functional connectivity of the pain network in fibromyalgia |
title |
Disrupted functional connectivity of the pain network in fibromyalgia |
spellingShingle |
Disrupted functional connectivity of the pain network in fibromyalgia Cifre, Ignacio CHRONIC PAIN FIBROMYALGIA FUNCTIONAL CONNECTIVITY PARTIAL CORRELATION ANALYSIS RESTING STATE |
title_short |
Disrupted functional connectivity of the pain network in fibromyalgia |
title_full |
Disrupted functional connectivity of the pain network in fibromyalgia |
title_fullStr |
Disrupted functional connectivity of the pain network in fibromyalgia |
title_full_unstemmed |
Disrupted functional connectivity of the pain network in fibromyalgia |
title_sort |
Disrupted functional connectivity of the pain network in fibromyalgia |
dc.creator.none.fl_str_mv |
Cifre, Ignacio Sitges, Carolina Fraiman, Daniel Muñoz, Miguel Ángel Balenzuela, Pablo González Roldán, Ana Martínez Jauand, Mercedes Birbaumer, Niels Chialvo, Dante Renato Montoya, Pedro |
author |
Cifre, Ignacio |
author_facet |
Cifre, Ignacio Sitges, Carolina Fraiman, Daniel Muñoz, Miguel Ángel Balenzuela, Pablo González Roldán, Ana Martínez Jauand, Mercedes Birbaumer, Niels Chialvo, Dante Renato Montoya, Pedro |
author_role |
author |
author2 |
Sitges, Carolina Fraiman, Daniel Muñoz, Miguel Ángel Balenzuela, Pablo González Roldán, Ana Martínez Jauand, Mercedes Birbaumer, Niels Chialvo, Dante Renato Montoya, Pedro |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
CHRONIC PAIN FIBROMYALGIA FUNCTIONAL CONNECTIVITY PARTIAL CORRELATION ANALYSIS RESTING STATE |
topic |
CHRONIC PAIN FIBROMYALGIA FUNCTIONAL CONNECTIVITY PARTIAL CORRELATION ANALYSIS RESTING STATE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen levelYdependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia ( p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values G .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values G .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values G .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values G .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r = j0.64, p = .003) and ACC (r = j0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggest- ing that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. Key words: fibromyalgia, chronic pain, resting state, functional connectivity, partial correlation analysis. Fil: Cifre, Ignacio. No especifíca; Fil: Sitges, Carolina. No especifíca; Fil: Fraiman, Daniel. Universidad de San Andrés; Argentina Fil: Muñoz, Miguel Ángel. No especifíca; Fil: Balenzuela, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina Fil: González Roldán, Ana. No especifíca; Fil: Martínez Jauand, Mercedes. No especifíca; Fil: Birbaumer, Niels. No especifíca; Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Montoya, Pedro. No especifíca; |
description |
Objective: To investigate the impact of chronic pain on brain dynamics at rest. Methods: Functional connectivity was examined in patients with fibromyalgia (FM) (n = 9) and healthy controls (n = 11) by calculating partial correlations between low-frequency blood oxygen levelYdependent fluctuations extracted from 15 brain regions. Results: Patients with FM had more positive and negative correlations within the pain network than healthy controls. Patients with FM displayed enhanced functional connectivity of the anterior cingulate cortex (ACC) with the insula (INS) and basal ganglia ( p values between .01 and .05), the secondary somatosensory area with the caudate (CAU) (p = .012), the primary motor cortex with the supplementary motor area (p = .007), the globus pallidus with the amygdala and superior temporal sulcus (both p values G .05), and the medial prefrontal cortex with the posterior cingulate cortex (PCC) and CAU (both p values G .05). Functional connectivity of the ACC with the amygdala and periaqueductal gray (PAG) matter (p values between .001 and .05), the thalamus with the INS and PAG (both p values G .01), the INS with the putamen (p = .038), the PAG with the CAU (p = .038), the secondary somatosensory area with the motor cortex and PCC (both p values G .05), and the PCC with the superior temporal sulcus (p = .002) was also reduced in FM. In addition, significant negative correlations were observed between depression and PAG connectivity strength with the thalamus (r = j0.64, p = .003) and ACC (r = j0.60, p = .004). Conclusions: These findings demonstrate that patients with FM display a substantial imbalance of the connectivity within the pain network during rest, suggest- ing that chronic pain may also lead to changes in brain activity during internally generated thought processes such as occur at rest. Key words: fibromyalgia, chronic pain, resting state, functional connectivity, partial correlation analysis. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/196757 Cifre, Ignacio; Sitges, Carolina; Fraiman, Daniel; Muñoz, Miguel Ángel; Balenzuela, Pablo; et al.; Disrupted functional connectivity of the pain network in fibromyalgia; Lippincott Williams; Psychosomatic Medicine; 74; 1; 1-2012; 55-62 0033-3174 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/196757 |
identifier_str_mv |
Cifre, Ignacio; Sitges, Carolina; Fraiman, Daniel; Muñoz, Miguel Ángel; Balenzuela, Pablo; et al.; Disrupted functional connectivity of the pain network in fibromyalgia; Lippincott Williams; Psychosomatic Medicine; 74; 1; 1-2012; 55-62 0033-3174 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.psychosomaticmedicine.org/content/74/1/55.abstract?sid=5d532b28-9f6b-4cdc-8bda-ea4c52d90882 info:eu-repo/semantics/altIdentifier/doi/10.1097/PSY.0b013e3182408f04 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Lippincott Williams |
publisher.none.fl_str_mv |
Lippincott Williams |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613311143870464 |
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13.070432 |