Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients

Autores
Gallina, Jessica; Zanon, Marco; Mikulan, Ezequiel Pablo; Pietrelli, Mattia; Gambino, Silvia; Ibáñez, Santiago Agustín; Bertini, Caterina
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Emerging evidence suggests a role of the posterior cortices in regulating alpha oscillatory activity and organizing low-level processing in non-alpha frequency bands. Therefore, posterior brain lesions, which damage the neural circuits of the visual system, might affect functional connectivity patterns of brain rhythms. To test this hypothesis, eyes-closed resting state EEG signal was acquired from patients with hemianopia with left and right posterior lesions, patients without hemianopia with more anterior lesions and healthy controls. Left-lesioned hemianopics showed reduced intrahemispheric connectivity in the range of upper alpha only in the lesioned hemisphere, whereas right-lesioned hemianopics exhibited reduced intrahemispheric alpha connectivity in both hemispheres. In terms of network topology, these impairments were characterized by reduced local functional segregation, with no associated change in global functional integration. This suggests a crucial role of posterior cortices in promoting functional connectivity in the range of alpha. Right-lesioned hemianopics revealed also additional impairments in the theta range, with increased connectivity in this frequency band, characterized by both increased local segregated activity and decreased global integration. This indicates that lesions to right posterior cortices lead to stronger impairments in alpha connectivity and induce additional alterations in local and global low-level processing, suggesting a specialization of the right hemisphere in generating alpha oscillations and in coordinating complex interplays with lower frequency bands. Importantly, hemianopic patient’s visual performance in the blind field was linked to alpha functional connectivity, corroborating the notion that alpha oscillatory patterns represent a biomarker of the integrity and the functioning of the underlying visual system.
Fil: Gallina, Jessica. Universidad de Bologna; Italia
Fil: Zanon, Marco. Universidad de Bologna; Italia
Fil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Università degli Studi di Milano; Italia
Fil: Pietrelli, Mattia. Universidad de Bologna; Italia
Fil: Gambino, Silvia. Universidad de Bologna; Italia
Fil: Ibáñez, Santiago Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Bertini, Caterina. Universidad de Bologna; Italia
Materia
ALPHA OSCILLATIONS
FUNCTIONAL CONNECTIVITY
HEMIANOPIA
RESTING STATE
THETA OSCILLATIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/206119
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/206119
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network_name_str CONICET Digital (CONICET)
spelling Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patientsGallina, JessicaZanon, MarcoMikulan, Ezequiel PabloPietrelli, MattiaGambino, SilviaIbáñez, Santiago AgustínBertini, CaterinaALPHA OSCILLATIONSFUNCTIONAL CONNECTIVITYHEMIANOPIARESTING STATETHETA OSCILLATIONShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Emerging evidence suggests a role of the posterior cortices in regulating alpha oscillatory activity and organizing low-level processing in non-alpha frequency bands. Therefore, posterior brain lesions, which damage the neural circuits of the visual system, might affect functional connectivity patterns of brain rhythms. To test this hypothesis, eyes-closed resting state EEG signal was acquired from patients with hemianopia with left and right posterior lesions, patients without hemianopia with more anterior lesions and healthy controls. Left-lesioned hemianopics showed reduced intrahemispheric connectivity in the range of upper alpha only in the lesioned hemisphere, whereas right-lesioned hemianopics exhibited reduced intrahemispheric alpha connectivity in both hemispheres. In terms of network topology, these impairments were characterized by reduced local functional segregation, with no associated change in global functional integration. This suggests a crucial role of posterior cortices in promoting functional connectivity in the range of alpha. Right-lesioned hemianopics revealed also additional impairments in the theta range, with increased connectivity in this frequency band, characterized by both increased local segregated activity and decreased global integration. This indicates that lesions to right posterior cortices lead to stronger impairments in alpha connectivity and induce additional alterations in local and global low-level processing, suggesting a specialization of the right hemisphere in generating alpha oscillations and in coordinating complex interplays with lower frequency bands. Importantly, hemianopic patient’s visual performance in the blind field was linked to alpha functional connectivity, corroborating the notion that alpha oscillatory patterns represent a biomarker of the integrity and the functioning of the underlying visual system.Fil: Gallina, Jessica. Universidad de Bologna; ItaliaFil: Zanon, Marco. Universidad de Bologna; ItaliaFil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Università degli Studi di Milano; ItaliaFil: Pietrelli, Mattia. Universidad de Bologna; ItaliaFil: Gambino, Silvia. Universidad de Bologna; ItaliaFil: Ibáñez, Santiago Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; ChileFil: Bertini, Caterina. Universidad de Bologna; ItaliaSpringer Heidelberg2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/206119Gallina, Jessica; Zanon, Marco; Mikulan, Ezequiel Pablo; Pietrelli, Mattia; Gambino, Silvia; et al.; Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients; Springer Heidelberg; Brain Structure & Function; 227; 9; 12-2022; 2939-29561863-2653CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00429-022-02502-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:33Zoai:ri.conicet.gov.ar:11336/206119instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:33.36CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
title Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
spellingShingle Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
Gallina, Jessica
ALPHA OSCILLATIONS
FUNCTIONAL CONNECTIVITY
HEMIANOPIA
RESTING STATE
THETA OSCILLATIONS
title_short Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
title_full Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
title_fullStr Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
title_full_unstemmed Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
title_sort Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients
dc.creator.none.fl_str_mv Gallina, Jessica
Zanon, Marco
Mikulan, Ezequiel Pablo
Pietrelli, Mattia
Gambino, Silvia
Ibáñez, Santiago Agustín
Bertini, Caterina
author Gallina, Jessica
author_facet Gallina, Jessica
Zanon, Marco
Mikulan, Ezequiel Pablo
Pietrelli, Mattia
Gambino, Silvia
Ibáñez, Santiago Agustín
Bertini, Caterina
author_role author
author2 Zanon, Marco
Mikulan, Ezequiel Pablo
Pietrelli, Mattia
Gambino, Silvia
Ibáñez, Santiago Agustín
Bertini, Caterina
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ALPHA OSCILLATIONS
FUNCTIONAL CONNECTIVITY
HEMIANOPIA
RESTING STATE
THETA OSCILLATIONS
topic ALPHA OSCILLATIONS
FUNCTIONAL CONNECTIVITY
HEMIANOPIA
RESTING STATE
THETA OSCILLATIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Emerging evidence suggests a role of the posterior cortices in regulating alpha oscillatory activity and organizing low-level processing in non-alpha frequency bands. Therefore, posterior brain lesions, which damage the neural circuits of the visual system, might affect functional connectivity patterns of brain rhythms. To test this hypothesis, eyes-closed resting state EEG signal was acquired from patients with hemianopia with left and right posterior lesions, patients without hemianopia with more anterior lesions and healthy controls. Left-lesioned hemianopics showed reduced intrahemispheric connectivity in the range of upper alpha only in the lesioned hemisphere, whereas right-lesioned hemianopics exhibited reduced intrahemispheric alpha connectivity in both hemispheres. In terms of network topology, these impairments were characterized by reduced local functional segregation, with no associated change in global functional integration. This suggests a crucial role of posterior cortices in promoting functional connectivity in the range of alpha. Right-lesioned hemianopics revealed also additional impairments in the theta range, with increased connectivity in this frequency band, characterized by both increased local segregated activity and decreased global integration. This indicates that lesions to right posterior cortices lead to stronger impairments in alpha connectivity and induce additional alterations in local and global low-level processing, suggesting a specialization of the right hemisphere in generating alpha oscillations and in coordinating complex interplays with lower frequency bands. Importantly, hemianopic patient’s visual performance in the blind field was linked to alpha functional connectivity, corroborating the notion that alpha oscillatory patterns represent a biomarker of the integrity and the functioning of the underlying visual system.
Fil: Gallina, Jessica. Universidad de Bologna; Italia
Fil: Zanon, Marco. Universidad de Bologna; Italia
Fil: Mikulan, Ezequiel Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Università degli Studi di Milano; Italia
Fil: Pietrelli, Mattia. Universidad de Bologna; Italia
Fil: Gambino, Silvia. Universidad de Bologna; Italia
Fil: Ibáñez, Santiago Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Bertini, Caterina. Universidad de Bologna; Italia
description Emerging evidence suggests a role of the posterior cortices in regulating alpha oscillatory activity and organizing low-level processing in non-alpha frequency bands. Therefore, posterior brain lesions, which damage the neural circuits of the visual system, might affect functional connectivity patterns of brain rhythms. To test this hypothesis, eyes-closed resting state EEG signal was acquired from patients with hemianopia with left and right posterior lesions, patients without hemianopia with more anterior lesions and healthy controls. Left-lesioned hemianopics showed reduced intrahemispheric connectivity in the range of upper alpha only in the lesioned hemisphere, whereas right-lesioned hemianopics exhibited reduced intrahemispheric alpha connectivity in both hemispheres. In terms of network topology, these impairments were characterized by reduced local functional segregation, with no associated change in global functional integration. This suggests a crucial role of posterior cortices in promoting functional connectivity in the range of alpha. Right-lesioned hemianopics revealed also additional impairments in the theta range, with increased connectivity in this frequency band, characterized by both increased local segregated activity and decreased global integration. This indicates that lesions to right posterior cortices lead to stronger impairments in alpha connectivity and induce additional alterations in local and global low-level processing, suggesting a specialization of the right hemisphere in generating alpha oscillations and in coordinating complex interplays with lower frequency bands. Importantly, hemianopic patient’s visual performance in the blind field was linked to alpha functional connectivity, corroborating the notion that alpha oscillatory patterns represent a biomarker of the integrity and the functioning of the underlying visual system.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/206119
Gallina, Jessica; Zanon, Marco; Mikulan, Ezequiel Pablo; Pietrelli, Mattia; Gambino, Silvia; et al.; Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients; Springer Heidelberg; Brain Structure & Function; 227; 9; 12-2022; 2939-2956
1863-2653
CONICET Digital
CONICET
url http://hdl.handle.net/11336/206119
identifier_str_mv Gallina, Jessica; Zanon, Marco; Mikulan, Ezequiel Pablo; Pietrelli, Mattia; Gambino, Silvia; et al.; Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients; Springer Heidelberg; Brain Structure & Function; 227; 9; 12-2022; 2939-2956
1863-2653
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00429-022-02502-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Heidelberg
publisher.none.fl_str_mv Springer Heidelberg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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