Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
- Autores
- Barcelo Martinez, Ernesto; Gelves Ospina, Melissa; Navarro Lechuga, Edgar; Allegri, Ricardo Francisco; Orozco Acosta, Erick; Benitez Agudelo, Juan; Leon Jacobus, Alexandra; Roman, Nestor Fabian
- Año de publicación
- 2018
- Idioma
- español castellano
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective. To describe the relationship between neuropsychological variables and serum cortisol levels as a measure of physiological stress in patients with fibromyalgia.Methodology. A sample of 60 women was intentionally selected: 30 with Fibromyalgia diagnosis and 30 with normal controls. Cortisol levels were determined using two blood samples (AM and PM) and a neuropsychological and emotional battery was applied with a standardized protocol in Colombian population to evaluate different cognitive domains. Comparative and correlational non-parametric analyzes were performed, a multiple regression analysis to determine influences between variables.Results. Significant differences between the study groups in the neuropsychological variables (attention, memory, language, visual-constructive praxis and executive functions (EF), (p<0.05) were found, obtaining better scores in the control group. Significant correlations between the cortisol profile, with false acknowledgments of Rey auditory-verbal learning test, and with perseverative errors of the Wisconsin test were found. Multiple regression analysis predicts the influence of memory and EF variables on the cortisol profile in an 88.7%.Conclusions. The findings show that, in patients with FM, there are neuropsychological alterations, mainly in executive functioning (cognitive flexibility) and episodic memory (evocation and storage). Likewise, executive dysfunction is related to physiological stress reciprocally and in turn areconditioned by emotional alterations such as symptoms of depression, which supports the neurophysiological model that compromises the hypothalamic-pituitary-adrenal axis and the prefrontal cortex, rich in corticosteroid receptors.
Fil: Barcelo Martinez, Ernesto. Universidad de la Costa.; Colombia
Fil: Gelves Ospina, Melissa. Universidad de la Costa.; Colombia
Fil: Navarro Lechuga, Edgar. Universidad del Norte; Colombia
Fil: Allegri, Ricardo Francisco. Universidad de la Costa.; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Orozco Acosta, Erick. Universidad Simón Bolívar ; Colombia
Fil: Benitez Agudelo, Juan. Instituto Colombiano de Neuropedagogía; Colombia
Fil: Leon Jacobus, Alexandra. Universidad de la Costa.; Colombia
Fil: Roman, Nestor Fabian. Universidad de la Costa.; Colombia - Materia
-
Pain
Cortisol
Fibromyalgia
Cognition - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/117672
Ver los metadatos del registro completo
id |
CONICETDig_0e08114635d48654b40ef32eb0176ee2 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/117672 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with FibromyalgiaBarcelo Martinez, ErnestoGelves Ospina, MelissaNavarro Lechuga, EdgarAllegri, Ricardo FranciscoOrozco Acosta, ErickBenitez Agudelo, JuanLeon Jacobus, AlexandraRoman, Nestor FabianPainCortisolFibromyalgiaCognitionhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective. To describe the relationship between neuropsychological variables and serum cortisol levels as a measure of physiological stress in patients with fibromyalgia.Methodology. A sample of 60 women was intentionally selected: 30 with Fibromyalgia diagnosis and 30 with normal controls. Cortisol levels were determined using two blood samples (AM and PM) and a neuropsychological and emotional battery was applied with a standardized protocol in Colombian population to evaluate different cognitive domains. Comparative and correlational non-parametric analyzes were performed, a multiple regression analysis to determine influences between variables.Results. Significant differences between the study groups in the neuropsychological variables (attention, memory, language, visual-constructive praxis and executive functions (EF), (p<0.05) were found, obtaining better scores in the control group. Significant correlations between the cortisol profile, with false acknowledgments of Rey auditory-verbal learning test, and with perseverative errors of the Wisconsin test were found. Multiple regression analysis predicts the influence of memory and EF variables on the cortisol profile in an 88.7%.Conclusions. The findings show that, in patients with FM, there are neuropsychological alterations, mainly in executive functioning (cognitive flexibility) and episodic memory (evocation and storage). Likewise, executive dysfunction is related to physiological stress reciprocally and in turn areconditioned by emotional alterations such as symptoms of depression, which supports the neurophysiological model that compromises the hypothalamic-pituitary-adrenal axis and the prefrontal cortex, rich in corticosteroid receptors.Fil: Barcelo Martinez, Ernesto. Universidad de la Costa.; ColombiaFil: Gelves Ospina, Melissa. Universidad de la Costa.; ColombiaFil: Navarro Lechuga, Edgar. Universidad del Norte; ColombiaFil: Allegri, Ricardo Francisco. Universidad de la Costa.; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Orozco Acosta, Erick. Universidad Simón Bolívar ; ColombiaFil: Benitez Agudelo, Juan. Instituto Colombiano de Neuropedagogía; ColombiaFil: Leon Jacobus, Alexandra. Universidad de la Costa.; ColombiaFil: Roman, Nestor Fabian. Universidad de la Costa.; ColombiaGrupo Ars Xxi Comunicacion S L2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117672Barcelo Martinez, Ernesto; Gelves Ospina, Melissa; Navarro Lechuga, Edgar; Allegri, Ricardo Francisco; Orozco Acosta, Erick; et al.; Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia; Grupo Ars Xxi Comunicacion S L; Actas Españolas de Psiquiatría; 46; 1; 2-2018; 1-111139-9287CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/29417976/info:eu-repo/semantics/altIdentifier/url/https://www.actaspsiquiatria.es/repositorio/20/111/ENG/20-111-ENG-1-11-302397.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:05Zoai:ri.conicet.gov.ar:11336/117672instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:06.062CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia |
title |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia |
spellingShingle |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia Barcelo Martinez, Ernesto Pain Cortisol Fibromyalgia Cognition |
title_short |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia |
title_full |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia |
title_fullStr |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia |
title_full_unstemmed |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia |
title_sort |
Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia |
dc.creator.none.fl_str_mv |
Barcelo Martinez, Ernesto Gelves Ospina, Melissa Navarro Lechuga, Edgar Allegri, Ricardo Francisco Orozco Acosta, Erick Benitez Agudelo, Juan Leon Jacobus, Alexandra Roman, Nestor Fabian |
author |
Barcelo Martinez, Ernesto |
author_facet |
Barcelo Martinez, Ernesto Gelves Ospina, Melissa Navarro Lechuga, Edgar Allegri, Ricardo Francisco Orozco Acosta, Erick Benitez Agudelo, Juan Leon Jacobus, Alexandra Roman, Nestor Fabian |
author_role |
author |
author2 |
Gelves Ospina, Melissa Navarro Lechuga, Edgar Allegri, Ricardo Francisco Orozco Acosta, Erick Benitez Agudelo, Juan Leon Jacobus, Alexandra Roman, Nestor Fabian |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Pain Cortisol Fibromyalgia Cognition |
topic |
Pain Cortisol Fibromyalgia Cognition |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objective. To describe the relationship between neuropsychological variables and serum cortisol levels as a measure of physiological stress in patients with fibromyalgia.Methodology. A sample of 60 women was intentionally selected: 30 with Fibromyalgia diagnosis and 30 with normal controls. Cortisol levels were determined using two blood samples (AM and PM) and a neuropsychological and emotional battery was applied with a standardized protocol in Colombian population to evaluate different cognitive domains. Comparative and correlational non-parametric analyzes were performed, a multiple regression analysis to determine influences between variables.Results. Significant differences between the study groups in the neuropsychological variables (attention, memory, language, visual-constructive praxis and executive functions (EF), (p<0.05) were found, obtaining better scores in the control group. Significant correlations between the cortisol profile, with false acknowledgments of Rey auditory-verbal learning test, and with perseverative errors of the Wisconsin test were found. Multiple regression analysis predicts the influence of memory and EF variables on the cortisol profile in an 88.7%.Conclusions. The findings show that, in patients with FM, there are neuropsychological alterations, mainly in executive functioning (cognitive flexibility) and episodic memory (evocation and storage). Likewise, executive dysfunction is related to physiological stress reciprocally and in turn areconditioned by emotional alterations such as symptoms of depression, which supports the neurophysiological model that compromises the hypothalamic-pituitary-adrenal axis and the prefrontal cortex, rich in corticosteroid receptors. Fil: Barcelo Martinez, Ernesto. Universidad de la Costa.; Colombia Fil: Gelves Ospina, Melissa. Universidad de la Costa.; Colombia Fil: Navarro Lechuga, Edgar. Universidad del Norte; Colombia Fil: Allegri, Ricardo Francisco. Universidad de la Costa.; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Orozco Acosta, Erick. Universidad Simón Bolívar ; Colombia Fil: Benitez Agudelo, Juan. Instituto Colombiano de Neuropedagogía; Colombia Fil: Leon Jacobus, Alexandra. Universidad de la Costa.; Colombia Fil: Roman, Nestor Fabian. Universidad de la Costa.; Colombia |
description |
Objective. To describe the relationship between neuropsychological variables and serum cortisol levels as a measure of physiological stress in patients with fibromyalgia.Methodology. A sample of 60 women was intentionally selected: 30 with Fibromyalgia diagnosis and 30 with normal controls. Cortisol levels were determined using two blood samples (AM and PM) and a neuropsychological and emotional battery was applied with a standardized protocol in Colombian population to evaluate different cognitive domains. Comparative and correlational non-parametric analyzes were performed, a multiple regression analysis to determine influences between variables.Results. Significant differences between the study groups in the neuropsychological variables (attention, memory, language, visual-constructive praxis and executive functions (EF), (p<0.05) were found, obtaining better scores in the control group. Significant correlations between the cortisol profile, with false acknowledgments of Rey auditory-verbal learning test, and with perseverative errors of the Wisconsin test were found. Multiple regression analysis predicts the influence of memory and EF variables on the cortisol profile in an 88.7%.Conclusions. The findings show that, in patients with FM, there are neuropsychological alterations, mainly in executive functioning (cognitive flexibility) and episodic memory (evocation and storage). Likewise, executive dysfunction is related to physiological stress reciprocally and in turn areconditioned by emotional alterations such as symptoms of depression, which supports the neurophysiological model that compromises the hypothalamic-pituitary-adrenal axis and the prefrontal cortex, rich in corticosteroid receptors. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/117672 Barcelo Martinez, Ernesto; Gelves Ospina, Melissa; Navarro Lechuga, Edgar; Allegri, Ricardo Francisco; Orozco Acosta, Erick; et al.; Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia; Grupo Ars Xxi Comunicacion S L; Actas Españolas de Psiquiatría; 46; 1; 2-2018; 1-11 1139-9287 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/117672 |
identifier_str_mv |
Barcelo Martinez, Ernesto; Gelves Ospina, Melissa; Navarro Lechuga, Edgar; Allegri, Ricardo Francisco; Orozco Acosta, Erick; et al.; Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia; Grupo Ars Xxi Comunicacion S L; Actas Españolas de Psiquiatría; 46; 1; 2-2018; 1-11 1139-9287 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/29417976/ info:eu-repo/semantics/altIdentifier/url/https://www.actaspsiquiatria.es/repositorio/20/111/ENG/20-111-ENG-1-11-302397.pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Grupo Ars Xxi Comunicacion S L |
publisher.none.fl_str_mv |
Grupo Ars Xxi Comunicacion S L |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1846782355531890688 |
score |
12.982451 |