Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia

Autores
Barcelo Martinez, Ernesto; Gelves Ospina, Melissa; Navarro Lechuga, Edgar; Allegri, Ricardo Francisco; Orozco Acosta, Erick; Benitez Agudelo, Juan; Leon Jacobus, Alexandra; Roman, Nestor Fabian
Año de publicación
2018
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective. To describe the relationship between neuropsychological variables and serum cortisol levels as a measure of physiological stress in patients with fibromyalgia.Methodology. A sample of 60 women was intentionally selected: 30 with Fibromyalgia diagnosis and 30 with normal controls. Cortisol levels were determined using two blood samples (AM and PM) and a neuropsychological and emotional battery was applied with a standardized protocol in Colombian population to evaluate different cognitive domains. Comparative and correlational non-parametric analyzes were performed, a multiple regression analysis to determine influences between variables.Results. Significant differences between the study groups in the neuropsychological variables (attention, memory, language, visual-constructive praxis and executive functions (EF), (p<0.05) were found, obtaining better scores in the control group. Significant correlations between the cortisol profile, with false acknowledgments of Rey auditory-verbal learning test, and with perseverative errors of the Wisconsin test were found. Multiple regression analysis predicts the influence of memory and EF variables on the cortisol profile in an 88.7%.Conclusions. The findings show that, in patients with FM, there are neuropsychological alterations, mainly in executive functioning (cognitive flexibility) and episodic memory (evocation and storage). Likewise, executive dysfunction is related to physiological stress reciprocally and in turn areconditioned by emotional alterations such as symptoms of depression, which supports the neurophysiological model that compromises the hypothalamic-pituitary-adrenal axis and the prefrontal cortex, rich in corticosteroid receptors.
Fil: Barcelo Martinez, Ernesto. Universidad de la Costa.; Colombia
Fil: Gelves Ospina, Melissa. Universidad de la Costa.; Colombia
Fil: Navarro Lechuga, Edgar. Universidad del Norte; Colombia
Fil: Allegri, Ricardo Francisco. Universidad de la Costa.; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Orozco Acosta, Erick. Universidad Simón Bolívar ; Colombia
Fil: Benitez Agudelo, Juan. Instituto Colombiano de Neuropedagogía; Colombia
Fil: Leon Jacobus, Alexandra. Universidad de la Costa.; Colombia
Fil: Roman, Nestor Fabian. Universidad de la Costa.; Colombia
Materia
Pain
Cortisol
Fibromyalgia
Cognition
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117672
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/117672
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Serum cortisol levels and neuropsychological impairments in patients diagnosed with FibromyalgiaBarcelo Martinez, ErnestoGelves Ospina, MelissaNavarro Lechuga, EdgarAllegri, Ricardo FranciscoOrozco Acosta, ErickBenitez Agudelo, JuanLeon Jacobus, AlexandraRoman, Nestor FabianPainCortisolFibromyalgiaCognitionhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective. To describe the relationship between neuropsychological variables and serum cortisol levels as a measure of physiological stress in patients with fibromyalgia.Methodology. A sample of 60 women was intentionally selected: 30 with Fibromyalgia diagnosis and 30 with normal controls. Cortisol levels were determined using two blood samples (AM and PM) and a neuropsychological and emotional battery was applied with a standardized protocol in Colombian population to evaluate different cognitive domains. Comparative and correlational non-parametric analyzes were performed, a multiple regression analysis to determine influences between variables.Results. Significant differences between the study groups in the neuropsychological variables (attention, memory, language, visual-constructive praxis and executive functions (EF), (p<0.05) were found, obtaining better scores in the control group. Significant correlations between the cortisol profile, with false acknowledgments of Rey auditory-verbal learning test, and with perseverative errors of the Wisconsin test were found. Multiple regression analysis predicts the influence of memory and EF variables on the cortisol profile in an 88.7%.Conclusions. The findings show that, in patients with FM, there are neuropsychological alterations, mainly in executive functioning (cognitive flexibility) and episodic memory (evocation and storage). Likewise, executive dysfunction is related to physiological stress reciprocally and in turn areconditioned by emotional alterations such as symptoms of depression, which supports the neurophysiological model that compromises the hypothalamic-pituitary-adrenal axis and the prefrontal cortex, rich in corticosteroid receptors.Fil: Barcelo Martinez, Ernesto. Universidad de la Costa.; ColombiaFil: Gelves Ospina, Melissa. Universidad de la Costa.; ColombiaFil: Navarro Lechuga, Edgar. Universidad del Norte; ColombiaFil: Allegri, Ricardo Francisco. Universidad de la Costa.; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Orozco Acosta, Erick. Universidad Simón Bolívar ; ColombiaFil: Benitez Agudelo, Juan. Instituto Colombiano de Neuropedagogía; ColombiaFil: Leon Jacobus, Alexandra. Universidad de la Costa.; ColombiaFil: Roman, Nestor Fabian. Universidad de la Costa.; ColombiaGrupo Ars Xxi Comunicacion S L2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117672Barcelo Martinez, Ernesto; Gelves Ospina, Melissa; Navarro Lechuga, Edgar; Allegri, Ricardo Francisco; Orozco Acosta, Erick; et al.; Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia; Grupo Ars Xxi Comunicacion S L; Actas Españolas de Psiquiatría; 46; 1; 2-2018; 1-111139-9287CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/29417976/info:eu-repo/semantics/altIdentifier/url/https://www.actaspsiquiatria.es/repositorio/20/111/ENG/20-111-ENG-1-11-302397.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:05Zoai:ri.conicet.gov.ar:11336/117672instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:06.062CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
title Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
spellingShingle Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
Barcelo Martinez, Ernesto
Pain
Cortisol
Fibromyalgia
Cognition
title_short Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
title_full Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
title_fullStr Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
title_full_unstemmed Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
title_sort Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia
dc.creator.none.fl_str_mv Barcelo Martinez, Ernesto
Gelves Ospina, Melissa
Navarro Lechuga, Edgar
Allegri, Ricardo Francisco
Orozco Acosta, Erick
Benitez Agudelo, Juan
Leon Jacobus, Alexandra
Roman, Nestor Fabian
author Barcelo Martinez, Ernesto
author_facet Barcelo Martinez, Ernesto
Gelves Ospina, Melissa
Navarro Lechuga, Edgar
Allegri, Ricardo Francisco
Orozco Acosta, Erick
Benitez Agudelo, Juan
Leon Jacobus, Alexandra
Roman, Nestor Fabian
author_role author
author2 Gelves Ospina, Melissa
Navarro Lechuga, Edgar
Allegri, Ricardo Francisco
Orozco Acosta, Erick
Benitez Agudelo, Juan
Leon Jacobus, Alexandra
Roman, Nestor Fabian
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pain
Cortisol
Fibromyalgia
Cognition
topic Pain
Cortisol
Fibromyalgia
Cognition
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective. To describe the relationship between neuropsychological variables and serum cortisol levels as a measure of physiological stress in patients with fibromyalgia.Methodology. A sample of 60 women was intentionally selected: 30 with Fibromyalgia diagnosis and 30 with normal controls. Cortisol levels were determined using two blood samples (AM and PM) and a neuropsychological and emotional battery was applied with a standardized protocol in Colombian population to evaluate different cognitive domains. Comparative and correlational non-parametric analyzes were performed, a multiple regression analysis to determine influences between variables.Results. Significant differences between the study groups in the neuropsychological variables (attention, memory, language, visual-constructive praxis and executive functions (EF), (p<0.05) were found, obtaining better scores in the control group. Significant correlations between the cortisol profile, with false acknowledgments of Rey auditory-verbal learning test, and with perseverative errors of the Wisconsin test were found. Multiple regression analysis predicts the influence of memory and EF variables on the cortisol profile in an 88.7%.Conclusions. The findings show that, in patients with FM, there are neuropsychological alterations, mainly in executive functioning (cognitive flexibility) and episodic memory (evocation and storage). Likewise, executive dysfunction is related to physiological stress reciprocally and in turn areconditioned by emotional alterations such as symptoms of depression, which supports the neurophysiological model that compromises the hypothalamic-pituitary-adrenal axis and the prefrontal cortex, rich in corticosteroid receptors.
Fil: Barcelo Martinez, Ernesto. Universidad de la Costa.; Colombia
Fil: Gelves Ospina, Melissa. Universidad de la Costa.; Colombia
Fil: Navarro Lechuga, Edgar. Universidad del Norte; Colombia
Fil: Allegri, Ricardo Francisco. Universidad de la Costa.; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Orozco Acosta, Erick. Universidad Simón Bolívar ; Colombia
Fil: Benitez Agudelo, Juan. Instituto Colombiano de Neuropedagogía; Colombia
Fil: Leon Jacobus, Alexandra. Universidad de la Costa.; Colombia
Fil: Roman, Nestor Fabian. Universidad de la Costa.; Colombia
description Objective. To describe the relationship between neuropsychological variables and serum cortisol levels as a measure of physiological stress in patients with fibromyalgia.Methodology. A sample of 60 women was intentionally selected: 30 with Fibromyalgia diagnosis and 30 with normal controls. Cortisol levels were determined using two blood samples (AM and PM) and a neuropsychological and emotional battery was applied with a standardized protocol in Colombian population to evaluate different cognitive domains. Comparative and correlational non-parametric analyzes were performed, a multiple regression analysis to determine influences between variables.Results. Significant differences between the study groups in the neuropsychological variables (attention, memory, language, visual-constructive praxis and executive functions (EF), (p<0.05) were found, obtaining better scores in the control group. Significant correlations between the cortisol profile, with false acknowledgments of Rey auditory-verbal learning test, and with perseverative errors of the Wisconsin test were found. Multiple regression analysis predicts the influence of memory and EF variables on the cortisol profile in an 88.7%.Conclusions. The findings show that, in patients with FM, there are neuropsychological alterations, mainly in executive functioning (cognitive flexibility) and episodic memory (evocation and storage). Likewise, executive dysfunction is related to physiological stress reciprocally and in turn areconditioned by emotional alterations such as symptoms of depression, which supports the neurophysiological model that compromises the hypothalamic-pituitary-adrenal axis and the prefrontal cortex, rich in corticosteroid receptors.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117672
Barcelo Martinez, Ernesto; Gelves Ospina, Melissa; Navarro Lechuga, Edgar; Allegri, Ricardo Francisco; Orozco Acosta, Erick; et al.; Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia; Grupo Ars Xxi Comunicacion S L; Actas Españolas de Psiquiatría; 46; 1; 2-2018; 1-11
1139-9287
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117672
identifier_str_mv Barcelo Martinez, Ernesto; Gelves Ospina, Melissa; Navarro Lechuga, Edgar; Allegri, Ricardo Francisco; Orozco Acosta, Erick; et al.; Serum cortisol levels and neuropsychological impairments in patients diagnosed with Fibromyalgia; Grupo Ars Xxi Comunicacion S L; Actas Españolas de Psiquiatría; 46; 1; 2-2018; 1-11
1139-9287
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/29417976/
info:eu-repo/semantics/altIdentifier/url/https://www.actaspsiquiatria.es/repositorio/20/111/ENG/20-111-ENG-1-11-302397.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Grupo Ars Xxi Comunicacion S L
publisher.none.fl_str_mv Grupo Ars Xxi Comunicacion S L
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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