Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate

Autores
Silva, Raúl Alejandro; Masi, Adriana Noemi
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A new, simple and precise indirect method for the determination of terazosin through x-ray fluorescence (XRF) is proposed. The method is based on the precipitation of an ion-associate complex formed between terazosin and [Zn(SCN)4]2- and the formation of a thin film on a membrane filter. The optimum conditions for ion-associate complex formation, such as pH, ionic strength, shaking time and stoichiometry of the complex, were studied. The complex was retained on the membrane filter, and the Zn Kα line was measured by XRF. The method presents the advantages of the separation of the drug from the matrix (excipients), the preconcentration of Zn, producing enhancement of XRF intensity though increased sensitivity, and the elimination of the matrix effects due to the thin film obtained. The lowest detection limit was 0.732 μg ml-1. The validation studies were realized by the related applications and the results were evaluated statistically. The method was successfully applied to terazosin determination in tablets or in bulk.
Fil: Silva, Raúl Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis; Argentina
Fil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
TERAZOSIN
ION PAIR COMPLEX
x-RAY FLUORESCENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98888
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/98888
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanateSilva, Raúl AlejandroMasi, Adriana NoemiTERAZOSINION PAIR COMPLEXx-RAY FLUORESCENCEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A new, simple and precise indirect method for the determination of terazosin through x-ray fluorescence (XRF) is proposed. The method is based on the precipitation of an ion-associate complex formed between terazosin and [Zn(SCN)4]2- and the formation of a thin film on a membrane filter. The optimum conditions for ion-associate complex formation, such as pH, ionic strength, shaking time and stoichiometry of the complex, were studied. The complex was retained on the membrane filter, and the Zn Kα line was measured by XRF. The method presents the advantages of the separation of the drug from the matrix (excipients), the preconcentration of Zn, producing enhancement of XRF intensity though increased sensitivity, and the elimination of the matrix effects due to the thin film obtained. The lowest detection limit was 0.732 μg ml-1. The validation studies were realized by the related applications and the results were evaluated statistically. The method was successfully applied to terazosin determination in tablets or in bulk.Fil: Silva, Raúl Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis; ArgentinaFil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaJohn Wiley & Sons Ltd2007-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98888Silva, Raúl Alejandro; Masi, Adriana Noemi; Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate; John Wiley & Sons Ltd; X-ray Spectrometry; 36; 4; 7-2007; 279-2830049-8246CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/xrs.965info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/xrs.965info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:22Zoai:ri.conicet.gov.ar:11336/98888instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:22.841CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate
title Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate
spellingShingle Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate
Silva, Raúl Alejandro
TERAZOSIN
ION PAIR COMPLEX
x-RAY FLUORESCENCE
title_short Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate
title_full Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate
title_fullStr Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate
title_full_unstemmed Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate
title_sort Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate
dc.creator.none.fl_str_mv Silva, Raúl Alejandro
Masi, Adriana Noemi
author Silva, Raúl Alejandro
author_facet Silva, Raúl Alejandro
Masi, Adriana Noemi
author_role author
author2 Masi, Adriana Noemi
author2_role author
dc.subject.none.fl_str_mv TERAZOSIN
ION PAIR COMPLEX
x-RAY FLUORESCENCE
topic TERAZOSIN
ION PAIR COMPLEX
x-RAY FLUORESCENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A new, simple and precise indirect method for the determination of terazosin through x-ray fluorescence (XRF) is proposed. The method is based on the precipitation of an ion-associate complex formed between terazosin and [Zn(SCN)4]2- and the formation of a thin film on a membrane filter. The optimum conditions for ion-associate complex formation, such as pH, ionic strength, shaking time and stoichiometry of the complex, were studied. The complex was retained on the membrane filter, and the Zn Kα line was measured by XRF. The method presents the advantages of the separation of the drug from the matrix (excipients), the preconcentration of Zn, producing enhancement of XRF intensity though increased sensitivity, and the elimination of the matrix effects due to the thin film obtained. The lowest detection limit was 0.732 μg ml-1. The validation studies were realized by the related applications and the results were evaluated statistically. The method was successfully applied to terazosin determination in tablets or in bulk.
Fil: Silva, Raúl Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Luis; Argentina
Fil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description A new, simple and precise indirect method for the determination of terazosin through x-ray fluorescence (XRF) is proposed. The method is based on the precipitation of an ion-associate complex formed between terazosin and [Zn(SCN)4]2- and the formation of a thin film on a membrane filter. The optimum conditions for ion-associate complex formation, such as pH, ionic strength, shaking time and stoichiometry of the complex, were studied. The complex was retained on the membrane filter, and the Zn Kα line was measured by XRF. The method presents the advantages of the separation of the drug from the matrix (excipients), the preconcentration of Zn, producing enhancement of XRF intensity though increased sensitivity, and the elimination of the matrix effects due to the thin film obtained. The lowest detection limit was 0.732 μg ml-1. The validation studies were realized by the related applications and the results were evaluated statistically. The method was successfully applied to terazosin determination in tablets or in bulk.
publishDate 2007
dc.date.none.fl_str_mv 2007-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98888
Silva, Raúl Alejandro; Masi, Adriana Noemi; Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate; John Wiley & Sons Ltd; X-ray Spectrometry; 36; 4; 7-2007; 279-283
0049-8246
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98888
identifier_str_mv Silva, Raúl Alejandro; Masi, Adriana Noemi; Sensitive determination of terazosin by x-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate; John Wiley & Sons Ltd; X-ray Spectrometry; 36; 4; 7-2007; 279-283
0049-8246
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/xrs.965
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/xrs.965
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614481220468736
score 13.070432

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