Determination of terazosin by cloud point extraction-fluorimetric combined methodology
- Autores
- Wang, Chien Chun; Luconi, Marta Olga; Masi, Adriana Noemi; Fernández, Liliana
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A new sensitive and selective preconcentration-fluorimetric method for determination of terazosin based on its native fluorescence was developed. The analyte, initially present in aqueous matrix, was treated with an extractive non-ionic surfactant solution and separated by the clouding phenomenon. The optimum analytical conditions for terazosin assay were established. Under these conditions, linear calibration curves were obtained over the range of 1 × 10-5 to 7.0 μg mL-1 with detection and quantification limits of 1.11 × 10-5 and 3.7 × 10-5 μg mL-1, respectively. Additionally, the binding constant (KB) for the terazosin-PONPE 7.5 system was determined given a value of 1028 L mol-1. The developed coupled methodology, which thoroughly satisfies the typical requirements for pharmaceutical control processes, was proved to be appropriate for monitoring terazosin in actual pharmaceutical formulations and biological fluid sample. The results were validated by recovery test and by comparison with other reported methods, being highly satisfactory.
Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Luconi, Marta Olga. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina
Fil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernández, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina - Materia
-
CLOUD POINT EXTRACTION
FLUORESCENCE
PHARMACEUTICALS
TERAZOSIN
URINE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/92861
Ver los metadatos del registro completo
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Determination of terazosin by cloud point extraction-fluorimetric combined methodologyWang, Chien ChunLuconi, Marta OlgaMasi, Adriana NoemiFernández, LilianaCLOUD POINT EXTRACTIONFLUORESCENCEPHARMACEUTICALSTERAZOSINURINEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A new sensitive and selective preconcentration-fluorimetric method for determination of terazosin based on its native fluorescence was developed. The analyte, initially present in aqueous matrix, was treated with an extractive non-ionic surfactant solution and separated by the clouding phenomenon. The optimum analytical conditions for terazosin assay were established. Under these conditions, linear calibration curves were obtained over the range of 1 × 10-5 to 7.0 μg mL-1 with detection and quantification limits of 1.11 × 10-5 and 3.7 × 10-5 μg mL-1, respectively. Additionally, the binding constant (KB) for the terazosin-PONPE 7.5 system was determined given a value of 1028 L mol-1. The developed coupled methodology, which thoroughly satisfies the typical requirements for pharmaceutical control processes, was proved to be appropriate for monitoring terazosin in actual pharmaceutical formulations and biological fluid sample. The results were validated by recovery test and by comparison with other reported methods, being highly satisfactory.Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Luconi, Marta Olga. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; ArgentinaFil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Fernández, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaElsevier Science2007-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92861Wang, Chien Chun; Luconi, Marta Olga; Masi, Adriana Noemi; Fernández, Liliana; Determination of terazosin by cloud point extraction-fluorimetric combined methodology; Elsevier Science; Talanta; 72; 5; 7-2007; 1779-17850039-9140CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2007.02.010info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0039914007001373info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:20Zoai:ri.conicet.gov.ar:11336/92861instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:20.304CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Determination of terazosin by cloud point extraction-fluorimetric combined methodology |
| title |
Determination of terazosin by cloud point extraction-fluorimetric combined methodology |
| spellingShingle |
Determination of terazosin by cloud point extraction-fluorimetric combined methodology Wang, Chien Chun CLOUD POINT EXTRACTION FLUORESCENCE PHARMACEUTICALS TERAZOSIN URINE |
| title_short |
Determination of terazosin by cloud point extraction-fluorimetric combined methodology |
| title_full |
Determination of terazosin by cloud point extraction-fluorimetric combined methodology |
| title_fullStr |
Determination of terazosin by cloud point extraction-fluorimetric combined methodology |
| title_full_unstemmed |
Determination of terazosin by cloud point extraction-fluorimetric combined methodology |
| title_sort |
Determination of terazosin by cloud point extraction-fluorimetric combined methodology |
| dc.creator.none.fl_str_mv |
Wang, Chien Chun Luconi, Marta Olga Masi, Adriana Noemi Fernández, Liliana |
| author |
Wang, Chien Chun |
| author_facet |
Wang, Chien Chun Luconi, Marta Olga Masi, Adriana Noemi Fernández, Liliana |
| author_role |
author |
| author2 |
Luconi, Marta Olga Masi, Adriana Noemi Fernández, Liliana |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
CLOUD POINT EXTRACTION FLUORESCENCE PHARMACEUTICALS TERAZOSIN URINE |
| topic |
CLOUD POINT EXTRACTION FLUORESCENCE PHARMACEUTICALS TERAZOSIN URINE |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
A new sensitive and selective preconcentration-fluorimetric method for determination of terazosin based on its native fluorescence was developed. The analyte, initially present in aqueous matrix, was treated with an extractive non-ionic surfactant solution and separated by the clouding phenomenon. The optimum analytical conditions for terazosin assay were established. Under these conditions, linear calibration curves were obtained over the range of 1 × 10-5 to 7.0 μg mL-1 with detection and quantification limits of 1.11 × 10-5 and 3.7 × 10-5 μg mL-1, respectively. Additionally, the binding constant (KB) for the terazosin-PONPE 7.5 system was determined given a value of 1028 L mol-1. The developed coupled methodology, which thoroughly satisfies the typical requirements for pharmaceutical control processes, was proved to be appropriate for monitoring terazosin in actual pharmaceutical formulations and biological fluid sample. The results were validated by recovery test and by comparison with other reported methods, being highly satisfactory. Fil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Luconi, Marta Olga. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina Fil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina Fil: Fernández, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina |
| description |
A new sensitive and selective preconcentration-fluorimetric method for determination of terazosin based on its native fluorescence was developed. The analyte, initially present in aqueous matrix, was treated with an extractive non-ionic surfactant solution and separated by the clouding phenomenon. The optimum analytical conditions for terazosin assay were established. Under these conditions, linear calibration curves were obtained over the range of 1 × 10-5 to 7.0 μg mL-1 with detection and quantification limits of 1.11 × 10-5 and 3.7 × 10-5 μg mL-1, respectively. Additionally, the binding constant (KB) for the terazosin-PONPE 7.5 system was determined given a value of 1028 L mol-1. The developed coupled methodology, which thoroughly satisfies the typical requirements for pharmaceutical control processes, was proved to be appropriate for monitoring terazosin in actual pharmaceutical formulations and biological fluid sample. The results were validated by recovery test and by comparison with other reported methods, being highly satisfactory. |
| publishDate |
2007 |
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2007-07 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/92861 Wang, Chien Chun; Luconi, Marta Olga; Masi, Adriana Noemi; Fernández, Liliana; Determination of terazosin by cloud point extraction-fluorimetric combined methodology; Elsevier Science; Talanta; 72; 5; 7-2007; 1779-1785 0039-9140 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/92861 |
| identifier_str_mv |
Wang, Chien Chun; Luconi, Marta Olga; Masi, Adriana Noemi; Fernández, Liliana; Determination of terazosin by cloud point extraction-fluorimetric combined methodology; Elsevier Science; Talanta; 72; 5; 7-2007; 1779-1785 0039-9140 CONICET Digital CONICET |
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eng |
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Elsevier Science |
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Elsevier Science |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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