Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children

Autores
Albareda, María Cecilia; Olivera, Gabriela Carina; de Rissio, Ana María; Postan, Miriam
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We previously reported that the T cell compartment in chronically Trypanosoma cruzi-infected adult subjects display functional and phenotypic signs of immune senescence. This study aimed to investigate the differentiation and the senescent profile of the overall CD8+ T cell compartment in T. cruzi-infected children at the early stage of the disease. We found a lower percentage of naive (CD27+CD28+CD45RA+) and early antigen-experienced (CD45RA-CD27+CD28+), and higher percentages of late differentiated antigen-experienced (CD45RA -CD27-CD28-) CD8+ T cells in T. cruzi-infected children as compared with age-matched uninfected controls. The expression of the interleukin (IL)-7R is also decreased on naive and on antigen-experienced total CD8+ T cells with various degrees of differentiation. Conversely, the expression of HLA-DR, caspase-3, and CD57 did not vary on the total CD8+ T cell compartment. These findings suggest that the duration of the infection is relevant in the process of immune senescent that this parasite can induce. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Fil: Albareda, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; Argentina
Fil: Olivera, Gabriela Carina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; Argentina
Fil: de Rissio, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; Argentina
Fil: Postan, Miriam. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; Argentina
Materia
Trypanosoma cruzi
Infected children
Immunology
CD8 cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53730
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/53730
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected ChildrenAlbareda, María CeciliaOlivera, Gabriela Carinade Rissio, Ana MaríaPostan, MiriamTrypanosoma cruziInfected childrenImmunologyCD8 cellshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3We previously reported that the T cell compartment in chronically Trypanosoma cruzi-infected adult subjects display functional and phenotypic signs of immune senescence. This study aimed to investigate the differentiation and the senescent profile of the overall CD8+ T cell compartment in T. cruzi-infected children at the early stage of the disease. We found a lower percentage of naive (CD27+CD28+CD45RA+) and early antigen-experienced (CD45RA-CD27+CD28+), and higher percentages of late differentiated antigen-experienced (CD45RA -CD27-CD28-) CD8+ T cells in T. cruzi-infected children as compared with age-matched uninfected controls. The expression of the interleukin (IL)-7R is also decreased on naive and on antigen-experienced total CD8+ T cells with various degrees of differentiation. Conversely, the expression of HLA-DR, caspase-3, and CD57 did not vary on the total CD8+ T cell compartment. These findings suggest that the duration of the infection is relevant in the process of immune senescent that this parasite can induce. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.Fil: Albareda, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; ArgentinaFil: Olivera, Gabriela Carina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; ArgentinaFil: de Rissio, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; ArgentinaFil: Postan, Miriam. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; ArgentinaAmerican Society of Tropical Medicine and Hygiene2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53730Albareda, María Cecilia; Olivera, Gabriela Carina; de Rissio, Ana María; Postan, Miriam; Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 82; 5; 5-2010; 861-8640002-9637CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.2010.09-0604info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.2010.09-0604info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:40Zoai:ri.conicet.gov.ar:11336/53730instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:40.742CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children
title Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children
spellingShingle Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children
Albareda, María Cecilia
Trypanosoma cruzi
Infected children
Immunology
CD8 cells
title_short Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children
title_full Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children
title_fullStr Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children
title_full_unstemmed Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children
title_sort Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children
dc.creator.none.fl_str_mv Albareda, María Cecilia
Olivera, Gabriela Carina
de Rissio, Ana María
Postan, Miriam
author Albareda, María Cecilia
author_facet Albareda, María Cecilia
Olivera, Gabriela Carina
de Rissio, Ana María
Postan, Miriam
author_role author
author2 Olivera, Gabriela Carina
de Rissio, Ana María
Postan, Miriam
author2_role author
author
author
dc.subject.none.fl_str_mv Trypanosoma cruzi
Infected children
Immunology
CD8 cells
topic Trypanosoma cruzi
Infected children
Immunology
CD8 cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We previously reported that the T cell compartment in chronically Trypanosoma cruzi-infected adult subjects display functional and phenotypic signs of immune senescence. This study aimed to investigate the differentiation and the senescent profile of the overall CD8+ T cell compartment in T. cruzi-infected children at the early stage of the disease. We found a lower percentage of naive (CD27+CD28+CD45RA+) and early antigen-experienced (CD45RA-CD27+CD28+), and higher percentages of late differentiated antigen-experienced (CD45RA -CD27-CD28-) CD8+ T cells in T. cruzi-infected children as compared with age-matched uninfected controls. The expression of the interleukin (IL)-7R is also decreased on naive and on antigen-experienced total CD8+ T cells with various degrees of differentiation. Conversely, the expression of HLA-DR, caspase-3, and CD57 did not vary on the total CD8+ T cell compartment. These findings suggest that the duration of the infection is relevant in the process of immune senescent that this parasite can induce. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Fil: Albareda, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; Argentina
Fil: Olivera, Gabriela Carina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; Argentina
Fil: de Rissio, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; Argentina
Fil: Postan, Miriam. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; Argentina
description We previously reported that the T cell compartment in chronically Trypanosoma cruzi-infected adult subjects display functional and phenotypic signs of immune senescence. This study aimed to investigate the differentiation and the senescent profile of the overall CD8+ T cell compartment in T. cruzi-infected children at the early stage of the disease. We found a lower percentage of naive (CD27+CD28+CD45RA+) and early antigen-experienced (CD45RA-CD27+CD28+), and higher percentages of late differentiated antigen-experienced (CD45RA -CD27-CD28-) CD8+ T cells in T. cruzi-infected children as compared with age-matched uninfected controls. The expression of the interleukin (IL)-7R is also decreased on naive and on antigen-experienced total CD8+ T cells with various degrees of differentiation. Conversely, the expression of HLA-DR, caspase-3, and CD57 did not vary on the total CD8+ T cell compartment. These findings suggest that the duration of the infection is relevant in the process of immune senescent that this parasite can induce. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53730
Albareda, María Cecilia; Olivera, Gabriela Carina; de Rissio, Ana María; Postan, Miriam; Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 82; 5; 5-2010; 861-864
0002-9637
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53730
identifier_str_mv Albareda, María Cecilia; Olivera, Gabriela Carina; de Rissio, Ana María; Postan, Miriam; Assessment of CD8 + T Cell Differentiation in Trypanosoma cruzi -Infected Children; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 82; 5; 5-2010; 861-864
0002-9637
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.2010.09-0604
info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.2010.09-0604
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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