Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it

Autores
Acosta Rodriguez, Eva Virginia; Araujo Furlan, Cintia Liliana; Fiocca Vernengo, Facundo; Montes, Carolina Lucia; Gruppi, Adriana
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The protozoan Trypanosoma cruzi is the causative agent of Chagas' disease, endemic in Latin America but present worldwide. Research efforts have focused on the examination of immune mechanisms that mediate host protection as well as immunopathology during this parasitic infection. The study of CD8+ T cell immunity emerges as a key aspect given the critical importance of parasite-specific CD8+ T cells for host resistance throughout the infection. In recent years, new research has shed light on novel pathways that modulate the induction, maintenance, and regulation of CD8+ T cell responses to T. cruzi. This new knowledge is setting the ground for future vaccines and/or immunotherapies. Herein, we critically review and analyze the latest results published in the field.
Fil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Araujo Furlan, Cintia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Fiocca Vernengo, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
CD8+ T CELLS
CHAGAS' DISEASE
TRYPANOSOMA CRUZI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128762
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve itAcosta Rodriguez, Eva VirginiaAraujo Furlan, Cintia LilianaFiocca Vernengo, FacundoMontes, Carolina LuciaGruppi, AdrianaCD8+ T CELLSCHAGAS' DISEASETRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The protozoan Trypanosoma cruzi is the causative agent of Chagas' disease, endemic in Latin America but present worldwide. Research efforts have focused on the examination of immune mechanisms that mediate host protection as well as immunopathology during this parasitic infection. The study of CD8+ T cell immunity emerges as a key aspect given the critical importance of parasite-specific CD8+ T cells for host resistance throughout the infection. In recent years, new research has shed light on novel pathways that modulate the induction, maintenance, and regulation of CD8+ T cell responses to T. cruzi. This new knowledge is setting the ground for future vaccines and/or immunotherapies. Herein, we critically review and analyze the latest results published in the field.Fil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Araujo Furlan, Cintia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Fiocca Vernengo, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaElsevier2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128762Acosta Rodriguez, Eva Virginia; Araujo Furlan, Cintia Liliana; Fiocca Vernengo, Facundo; Montes, Carolina Lucia; Gruppi, Adriana; Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it; Elsevier; Trends In Parasitology; 35; 11; 11-2019; 899-9171471-4922CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S147149221930217Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.pt.2019.08.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:21:58Zoai:ri.conicet.gov.ar:11336/128762instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:21:58.755CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it
title Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it
spellingShingle Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it
Acosta Rodriguez, Eva Virginia
CD8+ T CELLS
CHAGAS' DISEASE
TRYPANOSOMA CRUZI
title_short Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it
title_full Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it
title_fullStr Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it
title_full_unstemmed Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it
title_sort Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it
dc.creator.none.fl_str_mv Acosta Rodriguez, Eva Virginia
Araujo Furlan, Cintia Liliana
Fiocca Vernengo, Facundo
Montes, Carolina Lucia
Gruppi, Adriana
author Acosta Rodriguez, Eva Virginia
author_facet Acosta Rodriguez, Eva Virginia
Araujo Furlan, Cintia Liliana
Fiocca Vernengo, Facundo
Montes, Carolina Lucia
Gruppi, Adriana
author_role author
author2 Araujo Furlan, Cintia Liliana
Fiocca Vernengo, Facundo
Montes, Carolina Lucia
Gruppi, Adriana
author2_role author
author
author
author
dc.subject.none.fl_str_mv CD8+ T CELLS
CHAGAS' DISEASE
TRYPANOSOMA CRUZI
topic CD8+ T CELLS
CHAGAS' DISEASE
TRYPANOSOMA CRUZI
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The protozoan Trypanosoma cruzi is the causative agent of Chagas' disease, endemic in Latin America but present worldwide. Research efforts have focused on the examination of immune mechanisms that mediate host protection as well as immunopathology during this parasitic infection. The study of CD8+ T cell immunity emerges as a key aspect given the critical importance of parasite-specific CD8+ T cells for host resistance throughout the infection. In recent years, new research has shed light on novel pathways that modulate the induction, maintenance, and regulation of CD8+ T cell responses to T. cruzi. This new knowledge is setting the ground for future vaccines and/or immunotherapies. Herein, we critically review and analyze the latest results published in the field.
Fil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Araujo Furlan, Cintia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Fiocca Vernengo, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description The protozoan Trypanosoma cruzi is the causative agent of Chagas' disease, endemic in Latin America but present worldwide. Research efforts have focused on the examination of immune mechanisms that mediate host protection as well as immunopathology during this parasitic infection. The study of CD8+ T cell immunity emerges as a key aspect given the critical importance of parasite-specific CD8+ T cells for host resistance throughout the infection. In recent years, new research has shed light on novel pathways that modulate the induction, maintenance, and regulation of CD8+ T cell responses to T. cruzi. This new knowledge is setting the ground for future vaccines and/or immunotherapies. Herein, we critically review and analyze the latest results published in the field.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128762
Acosta Rodriguez, Eva Virginia; Araujo Furlan, Cintia Liliana; Fiocca Vernengo, Facundo; Montes, Carolina Lucia; Gruppi, Adriana; Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it; Elsevier; Trends In Parasitology; 35; 11; 11-2019; 899-917
1471-4922
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128762
identifier_str_mv Acosta Rodriguez, Eva Virginia; Araujo Furlan, Cintia Liliana; Fiocca Vernengo, Facundo; Montes, Carolina Lucia; Gruppi, Adriana; Understanding CD8+ T cell immunity to Trypanosoma cruzi and how to improve it; Elsevier; Trends In Parasitology; 35; 11; 11-2019; 899-917
1471-4922
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S147149221930217X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pt.2019.08.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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