Transcriptional control of a plant stem cell niche

Autores
Busch, Wolfang; Miotk, Andrej; Ariel, Federico Damian; Zhao, Zhong; Forner, Joachim; Daum, Gabor; Suzaki, Takuya; Schuster, Christoph; Schultheiss, Sebastian J.; Leibfried, Andrea; Haubeiß, Silke; Ha, Nati; Chan, Raquel Lia; Lohmann, Jan U.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of CLAVATA1, which is part of a negative feedback regulation of WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.
Fil: Busch, Wolfang. Max Planck Institute For Developmental Biology; Alemania. University of Duke; Estados Unidos
Fil: Miotk, Andrej. University of Heidelberg; Alemania
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Zhao, Zhong. University of Heidelberg; Alemania
Fil: Forner, Joachim. University of Heidelberg; Alemania
Fil: Daum, Gabor. University of Heidelberg; Alemania
Fil: Suzaki, Takuya. University of Heidelberg; Alemania
Fil: Schuster, Christoph. University of Heidelberg; Alemania
Fil: Schultheiss, Sebastian J.. Max Planck Institute For Developmental Biology; Alemania
Fil: Leibfried, Andrea. Max Planck Institute For Developmental Biology; Alemania
Fil: Haubeiß, Silke. Max Planck Institute For Developmental Biology; Alemania
Fil: Ha, Nati. University of Heidelberg; Alemania
Fil: Chan, Raquel Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Lohmann, Jan U.. Max Planck Institute For Developmental Biology; Alemania. University of Heidelberg; Alemania
Materia
Wuschel
Clavata
Transcriptomics
Shoot Apical Meristem
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/75950
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/75950
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Transcriptional control of a plant stem cell nicheBusch, WolfangMiotk, AndrejAriel, Federico DamianZhao, ZhongForner, JoachimDaum, GaborSuzaki, TakuyaSchuster, ChristophSchultheiss, Sebastian J.Leibfried, AndreaHaubeiß, SilkeHa, NatiChan, Raquel LiaLohmann, Jan U.WuschelClavataTranscriptomicsShoot Apical Meristemhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of CLAVATA1, which is part of a negative feedback regulation of WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.Fil: Busch, Wolfang. Max Planck Institute For Developmental Biology; Alemania. University of Duke; Estados UnidosFil: Miotk, Andrej. University of Heidelberg; AlemaniaFil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Zhao, Zhong. University of Heidelberg; AlemaniaFil: Forner, Joachim. University of Heidelberg; AlemaniaFil: Daum, Gabor. University of Heidelberg; AlemaniaFil: Suzaki, Takuya. University of Heidelberg; AlemaniaFil: Schuster, Christoph. University of Heidelberg; AlemaniaFil: Schultheiss, Sebastian J.. Max Planck Institute For Developmental Biology; AlemaniaFil: Leibfried, Andrea. Max Planck Institute For Developmental Biology; AlemaniaFil: Haubeiß, Silke. Max Planck Institute For Developmental Biology; AlemaniaFil: Ha, Nati. University of Heidelberg; AlemaniaFil: Chan, Raquel Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Lohmann, Jan U.. Max Planck Institute For Developmental Biology; Alemania. University of Heidelberg; AlemaniaCell Press2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/75950Busch, Wolfang; Miotk, Andrej; Ariel, Federico Damian; Zhao, Zhong; Forner, Joachim; et al.; Transcriptional control of a plant stem cell niche; Cell Press; Developmental Cell; 18; 5; 5-2010; 841-8531534-5807CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.devcel.2010.03.012info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1534580710001516info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:32:06Zoai:ri.conicet.gov.ar:11336/75950instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:32:07.242CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Transcriptional control of a plant stem cell niche
title Transcriptional control of a plant stem cell niche
spellingShingle Transcriptional control of a plant stem cell niche
Busch, Wolfang
Wuschel
Clavata
Transcriptomics
Shoot Apical Meristem
title_short Transcriptional control of a plant stem cell niche
title_full Transcriptional control of a plant stem cell niche
title_fullStr Transcriptional control of a plant stem cell niche
title_full_unstemmed Transcriptional control of a plant stem cell niche
title_sort Transcriptional control of a plant stem cell niche
dc.creator.none.fl_str_mv Busch, Wolfang
Miotk, Andrej
Ariel, Federico Damian
Zhao, Zhong
Forner, Joachim
Daum, Gabor
Suzaki, Takuya
Schuster, Christoph
Schultheiss, Sebastian J.
Leibfried, Andrea
Haubeiß, Silke
Ha, Nati
Chan, Raquel Lia
Lohmann, Jan U.
author Busch, Wolfang
author_facet Busch, Wolfang
Miotk, Andrej
Ariel, Federico Damian
Zhao, Zhong
Forner, Joachim
Daum, Gabor
Suzaki, Takuya
Schuster, Christoph
Schultheiss, Sebastian J.
Leibfried, Andrea
Haubeiß, Silke
Ha, Nati
Chan, Raquel Lia
Lohmann, Jan U.
author_role author
author2 Miotk, Andrej
Ariel, Federico Damian
Zhao, Zhong
Forner, Joachim
Daum, Gabor
Suzaki, Takuya
Schuster, Christoph
Schultheiss, Sebastian J.
Leibfried, Andrea
Haubeiß, Silke
Ha, Nati
Chan, Raquel Lia
Lohmann, Jan U.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Wuschel
Clavata
Transcriptomics
Shoot Apical Meristem
topic Wuschel
Clavata
Transcriptomics
Shoot Apical Meristem
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of CLAVATA1, which is part of a negative feedback regulation of WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.
Fil: Busch, Wolfang. Max Planck Institute For Developmental Biology; Alemania. University of Duke; Estados Unidos
Fil: Miotk, Andrej. University of Heidelberg; Alemania
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Zhao, Zhong. University of Heidelberg; Alemania
Fil: Forner, Joachim. University of Heidelberg; Alemania
Fil: Daum, Gabor. University of Heidelberg; Alemania
Fil: Suzaki, Takuya. University of Heidelberg; Alemania
Fil: Schuster, Christoph. University of Heidelberg; Alemania
Fil: Schultheiss, Sebastian J.. Max Planck Institute For Developmental Biology; Alemania
Fil: Leibfried, Andrea. Max Planck Institute For Developmental Biology; Alemania
Fil: Haubeiß, Silke. Max Planck Institute For Developmental Biology; Alemania
Fil: Ha, Nati. University of Heidelberg; Alemania
Fil: Chan, Raquel Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Lohmann, Jan U.. Max Planck Institute For Developmental Biology; Alemania. University of Heidelberg; Alemania
description Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of CLAVATA1, which is part of a negative feedback regulation of WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/75950
Busch, Wolfang; Miotk, Andrej; Ariel, Federico Damian; Zhao, Zhong; Forner, Joachim; et al.; Transcriptional control of a plant stem cell niche; Cell Press; Developmental Cell; 18; 5; 5-2010; 841-853
1534-5807
CONICET Digital
CONICET
url http://hdl.handle.net/11336/75950
identifier_str_mv Busch, Wolfang; Miotk, Andrej; Ariel, Federico Damian; Zhao, Zhong; Forner, Joachim; et al.; Transcriptional control of a plant stem cell niche; Cell Press; Developmental Cell; 18; 5; 5-2010; 841-853
1534-5807
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.devcel.2010.03.012
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1534580710001516
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083455382716416
score 13.22299

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