Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
- Autores
- Albarellos, Gabriela Alejandra; Montoya, Laura; Passini, Sabrina Mariela; Lupi, Martin Pablo; Landoni, Maria Fabiana
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objectives: The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Methods: Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Results: Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Conclusions and relevance: Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen.
Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina - Materia
-
MEROPENEM
CAT
PHARMACOKINETICS
ANTIMICROBIALS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/129927
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Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to catsAlbarellos, Gabriela AlejandraMontoya, LauraPassini, Sabrina MarielaLupi, Martin PabloLandoni, Maria FabianaMEROPENEMCATPHARMACOKINETICSANTIMICROBIALShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Objectives: The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Methods: Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Results: Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Conclusions and relevance: Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen.Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaElsevier2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129927Albarellos, Gabriela Alejandra; Montoya, Laura; Passini, Sabrina Mariela; Lupi, Martin Pablo; Landoni, Maria Fabiana; Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats; Elsevier; Journal of Feline Medicine and Surgery; 18; 12; 9-2015; 976-9801098-612XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/1098612X15604655info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/1098612X15604655info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:06Zoai:ri.conicet.gov.ar:11336/129927instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:07.07CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats |
title |
Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats |
spellingShingle |
Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats Albarellos, Gabriela Alejandra MEROPENEM CAT PHARMACOKINETICS ANTIMICROBIALS |
title_short |
Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats |
title_full |
Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats |
title_fullStr |
Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats |
title_full_unstemmed |
Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats |
title_sort |
Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats |
dc.creator.none.fl_str_mv |
Albarellos, Gabriela Alejandra Montoya, Laura Passini, Sabrina Mariela Lupi, Martin Pablo Landoni, Maria Fabiana |
author |
Albarellos, Gabriela Alejandra |
author_facet |
Albarellos, Gabriela Alejandra Montoya, Laura Passini, Sabrina Mariela Lupi, Martin Pablo Landoni, Maria Fabiana |
author_role |
author |
author2 |
Montoya, Laura Passini, Sabrina Mariela Lupi, Martin Pablo Landoni, Maria Fabiana |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
MEROPENEM CAT PHARMACOKINETICS ANTIMICROBIALS |
topic |
MEROPENEM CAT PHARMACOKINETICS ANTIMICROBIALS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Objectives: The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Methods: Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Results: Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Conclusions and relevance: Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina |
description |
Objectives: The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Methods: Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Results: Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Conclusions and relevance: Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/129927 Albarellos, Gabriela Alejandra; Montoya, Laura; Passini, Sabrina Mariela; Lupi, Martin Pablo; Landoni, Maria Fabiana; Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats; Elsevier; Journal of Feline Medicine and Surgery; 18; 12; 9-2015; 976-980 1098-612X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/129927 |
identifier_str_mv |
Albarellos, Gabriela Alejandra; Montoya, Laura; Passini, Sabrina Mariela; Lupi, Martin Pablo; Landoni, Maria Fabiana; Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats; Elsevier; Journal of Feline Medicine and Surgery; 18; 12; 9-2015; 976-980 1098-612X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1177/1098612X15604655 info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/1098612X15604655 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |