Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats

Autores
Albarellos, Gabriela Alejandra; Montoya, Laura; Passini, Sabrina Mariela; Lupi, Martin Pablo; Landoni, Maria Fabiana
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Methods: Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Results: Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Conclusions and relevance: Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen.
Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
MEROPENEM
CAT
PHARMACOKINETICS
ANTIMICROBIALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129927
Acceder
id CONICETDig_4d41c4798d60492d742cc6cf339f23a7
oai_identifier_str oai:ri.conicet.gov.ar:11336/129927
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to catsAlbarellos, Gabriela AlejandraMontoya, LauraPassini, Sabrina MarielaLupi, Martin PabloLandoni, Maria FabianaMEROPENEMCATPHARMACOKINETICSANTIMICROBIALShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Objectives: The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Methods: Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Results: Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Conclusions and relevance: Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen.Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaElsevier2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129927Albarellos, Gabriela Alejandra; Montoya, Laura; Passini, Sabrina Mariela; Lupi, Martin Pablo; Landoni, Maria Fabiana; Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats; Elsevier; Journal of Feline Medicine and Surgery; 18; 12; 9-2015; 976-9801098-612XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/1098612X15604655info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/1098612X15604655info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:48:53Zoai:ri.conicet.gov.ar:11336/129927instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:48:53.316CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
title Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
spellingShingle Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
Albarellos, Gabriela Alejandra
MEROPENEM
CAT
PHARMACOKINETICS
ANTIMICROBIALS
title_short Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
title_full Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
title_fullStr Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
title_full_unstemmed Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
title_sort Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats
dc.creator.none.fl_str_mv Albarellos, Gabriela Alejandra
Montoya, Laura
Passini, Sabrina Mariela
Lupi, Martin Pablo
Landoni, Maria Fabiana
author Albarellos, Gabriela Alejandra
author_facet Albarellos, Gabriela Alejandra
Montoya, Laura
Passini, Sabrina Mariela
Lupi, Martin Pablo
Landoni, Maria Fabiana
author_role author
author2 Montoya, Laura
Passini, Sabrina Mariela
Lupi, Martin Pablo
Landoni, Maria Fabiana
author2_role author
author
author
author
dc.subject.none.fl_str_mv MEROPENEM
CAT
PHARMACOKINETICS
ANTIMICROBIALS
topic MEROPENEM
CAT
PHARMACOKINETICS
ANTIMICROBIALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Objectives: The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Methods: Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Results: Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Conclusions and relevance: Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen.
Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Passini, Sabrina Mariela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Lupi, Martin Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Objectives: The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Methods: Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Results: Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Conclusions and relevance: Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129927
Albarellos, Gabriela Alejandra; Montoya, Laura; Passini, Sabrina Mariela; Lupi, Martin Pablo; Landoni, Maria Fabiana; Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats; Elsevier; Journal of Feline Medicine and Surgery; 18; 12; 9-2015; 976-980
1098-612X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129927
identifier_str_mv Albarellos, Gabriela Alejandra; Montoya, Laura; Passini, Sabrina Mariela; Lupi, Martin Pablo; Landoni, Maria Fabiana; Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats; Elsevier; Journal of Feline Medicine and Surgery; 18; 12; 9-2015; 976-980
1098-612X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/1098612X15604655
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/1098612X15604655
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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