Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification

Autores
Carrascosa, Patricia; Leipsic, Jonathon A.; Deviggiano, Alejandro; Capunay, Carlos; Vallejos, Javier; Goldsmit, Alejandro; De Zan, Macarena; Rodriguez Granillo, Gaston Alfredo
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Rationale and Objectives We sought to explore the image quality and diagnostic performance of virtual monochromatic imaging derived from dual-energy computed tomography coronary angiography (DE-CTCA) in patients with intermediate to high likelihood of coronary artery disease (CAD) and the influence of calcification. Materials and Methods Consecutive symptomatic patients with suspected CAD referred for invasive coronary angiography who underwent DE-CTCA and a coronary artery calcium scoring before the invasive procedure comprised the study population. Results Sixty-seven patients were included. Image quality was significantly lower at 45 keV reconstructions (mean Likert score 45 keV 3.57 ± 0.6, 65 keV 4.07 ± 0.5, and 85 keV 4.09 ± 0.6; P < .0001). Patients with moderate calcification showed a trend toward a significant improvement in the diagnostic performance with 65 keV vs 45 keV reconstructions (45 keV, area under the curve 0.92 [95% confidence interval 0.89–0.95] vs 65 keV, area under the curve 0.96 [95% confidence interval 0.93–0.98], P = .06). The diagnostic performance of DE-CTCA was significantly lower in segments with higher coronary artery calcium scoring compared to segments with none or mild calcification, independent of the energy level applied. Conclusions In patients with intermediate to high likelihood of CAD, DE-CTCA had a good diagnostic performance, although significantly lower in segments with severe calcification.
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina
Fil: Leipsic, Jonathon A.. St. Paul's Hospital; Canadá
Fil: Deviggiano, Alejandro. Diagnóstico Maipú; Argentina
Fil: Capunay, Carlos. Diagnóstico Maipú; Argentina
Fil: Vallejos, Javier. Diagnóstico Maipú; Argentina
Fil: Goldsmit, Alejandro. Sanatorio Güemes; Argentina
Fil: De Zan, Macarena. Diagnóstico Maipú; Argentina
Fil: Rodriguez Granillo, Gaston Alfredo. Diagnóstico Maipú; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
Spectral
Angiogram
Imaging
Kilovolt
Specificity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41813
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary CalcificationCarrascosa, PatriciaLeipsic, Jonathon A.Deviggiano, AlejandroCapunay, CarlosVallejos, JavierGoldsmit, AlejandroDe Zan, MacarenaRodriguez Granillo, Gaston AlfredoSpectralAngiogramImagingKilovoltSpecificityhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Rationale and Objectives We sought to explore the image quality and diagnostic performance of virtual monochromatic imaging derived from dual-energy computed tomography coronary angiography (DE-CTCA) in patients with intermediate to high likelihood of coronary artery disease (CAD) and the influence of calcification. Materials and Methods Consecutive symptomatic patients with suspected CAD referred for invasive coronary angiography who underwent DE-CTCA and a coronary artery calcium scoring before the invasive procedure comprised the study population. Results Sixty-seven patients were included. Image quality was significantly lower at 45 keV reconstructions (mean Likert score 45 keV 3.57 ± 0.6, 65 keV 4.07 ± 0.5, and 85 keV 4.09 ± 0.6; P < .0001). Patients with moderate calcification showed a trend toward a significant improvement in the diagnostic performance with 65 keV vs 45 keV reconstructions (45 keV, area under the curve 0.92 [95% confidence interval 0.89–0.95] vs 65 keV, area under the curve 0.96 [95% confidence interval 0.93–0.98], P = .06). The diagnostic performance of DE-CTCA was significantly lower in segments with higher coronary artery calcium scoring compared to segments with none or mild calcification, independent of the energy level applied. Conclusions In patients with intermediate to high likelihood of CAD, DE-CTCA had a good diagnostic performance, although significantly lower in segments with severe calcification.Fil: Carrascosa, Patricia. Diagnóstico Maipú; ArgentinaFil: Leipsic, Jonathon A.. St. Paul's Hospital; CanadáFil: Deviggiano, Alejandro. Diagnóstico Maipú; ArgentinaFil: Capunay, Carlos. Diagnóstico Maipú; ArgentinaFil: Vallejos, Javier. Diagnóstico Maipú; ArgentinaFil: Goldsmit, Alejandro. Sanatorio Güemes; ArgentinaFil: De Zan, Macarena. Diagnóstico Maipú; ArgentinaFil: Rodriguez Granillo, Gaston Alfredo. Diagnóstico Maipú; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaElsevier Science Inc2016-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordhttp://hdl.handle.net/11336/41813Carrascosa, Patricia; Leipsic, Jonathon A.; Deviggiano, Alejandro; Capunay, Carlos; Vallejos, Javier; et al.; Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification; Elsevier Science Inc; Academic Radiology; 23; 12; 12-2016; 1490-14971076-6332CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.acra.2016.08.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1076633216301775info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:11Zoai:ri.conicet.gov.ar:11336/41813instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:11.822CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification
title Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification
spellingShingle Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification
Carrascosa, Patricia
Spectral
Angiogram
Imaging
Kilovolt
Specificity
title_short Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification
title_full Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification
title_fullStr Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification
title_full_unstemmed Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification
title_sort Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification
dc.creator.none.fl_str_mv Carrascosa, Patricia
Leipsic, Jonathon A.
Deviggiano, Alejandro
Capunay, Carlos
Vallejos, Javier
Goldsmit, Alejandro
De Zan, Macarena
Rodriguez Granillo, Gaston Alfredo
author Carrascosa, Patricia
author_facet Carrascosa, Patricia
Leipsic, Jonathon A.
Deviggiano, Alejandro
Capunay, Carlos
Vallejos, Javier
Goldsmit, Alejandro
De Zan, Macarena
Rodriguez Granillo, Gaston Alfredo
author_role author
author2 Leipsic, Jonathon A.
Deviggiano, Alejandro
Capunay, Carlos
Vallejos, Javier
Goldsmit, Alejandro
De Zan, Macarena
Rodriguez Granillo, Gaston Alfredo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Spectral
Angiogram
Imaging
Kilovolt
Specificity
topic Spectral
Angiogram
Imaging
Kilovolt
Specificity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Rationale and Objectives We sought to explore the image quality and diagnostic performance of virtual monochromatic imaging derived from dual-energy computed tomography coronary angiography (DE-CTCA) in patients with intermediate to high likelihood of coronary artery disease (CAD) and the influence of calcification. Materials and Methods Consecutive symptomatic patients with suspected CAD referred for invasive coronary angiography who underwent DE-CTCA and a coronary artery calcium scoring before the invasive procedure comprised the study population. Results Sixty-seven patients were included. Image quality was significantly lower at 45 keV reconstructions (mean Likert score 45 keV 3.57 ± 0.6, 65 keV 4.07 ± 0.5, and 85 keV 4.09 ± 0.6; P < .0001). Patients with moderate calcification showed a trend toward a significant improvement in the diagnostic performance with 65 keV vs 45 keV reconstructions (45 keV, area under the curve 0.92 [95% confidence interval 0.89–0.95] vs 65 keV, area under the curve 0.96 [95% confidence interval 0.93–0.98], P = .06). The diagnostic performance of DE-CTCA was significantly lower in segments with higher coronary artery calcium scoring compared to segments with none or mild calcification, independent of the energy level applied. Conclusions In patients with intermediate to high likelihood of CAD, DE-CTCA had a good diagnostic performance, although significantly lower in segments with severe calcification.
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina
Fil: Leipsic, Jonathon A.. St. Paul's Hospital; Canadá
Fil: Deviggiano, Alejandro. Diagnóstico Maipú; Argentina
Fil: Capunay, Carlos. Diagnóstico Maipú; Argentina
Fil: Vallejos, Javier. Diagnóstico Maipú; Argentina
Fil: Goldsmit, Alejandro. Sanatorio Güemes; Argentina
Fil: De Zan, Macarena. Diagnóstico Maipú; Argentina
Fil: Rodriguez Granillo, Gaston Alfredo. Diagnóstico Maipú; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description Rationale and Objectives We sought to explore the image quality and diagnostic performance of virtual monochromatic imaging derived from dual-energy computed tomography coronary angiography (DE-CTCA) in patients with intermediate to high likelihood of coronary artery disease (CAD) and the influence of calcification. Materials and Methods Consecutive symptomatic patients with suspected CAD referred for invasive coronary angiography who underwent DE-CTCA and a coronary artery calcium scoring before the invasive procedure comprised the study population. Results Sixty-seven patients were included. Image quality was significantly lower at 45 keV reconstructions (mean Likert score 45 keV 3.57 ± 0.6, 65 keV 4.07 ± 0.5, and 85 keV 4.09 ± 0.6; P < .0001). Patients with moderate calcification showed a trend toward a significant improvement in the diagnostic performance with 65 keV vs 45 keV reconstructions (45 keV, area under the curve 0.92 [95% confidence interval 0.89–0.95] vs 65 keV, area under the curve 0.96 [95% confidence interval 0.93–0.98], P = .06). The diagnostic performance of DE-CTCA was significantly lower in segments with higher coronary artery calcium scoring compared to segments with none or mild calcification, independent of the energy level applied. Conclusions In patients with intermediate to high likelihood of CAD, DE-CTCA had a good diagnostic performance, although significantly lower in segments with severe calcification.
publishDate 2016
dc.date.none.fl_str_mv 2016-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41813
Carrascosa, Patricia; Leipsic, Jonathon A.; Deviggiano, Alejandro; Capunay, Carlos; Vallejos, Javier; et al.; Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification; Elsevier Science Inc; Academic Radiology; 23; 12; 12-2016; 1490-1497
1076-6332
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41813
identifier_str_mv Carrascosa, Patricia; Leipsic, Jonathon A.; Deviggiano, Alejandro; Capunay, Carlos; Vallejos, Javier; et al.; Virtual Monochromatic Imaging in Patients with Intermediate to High Likelihood of Coronary Artery Disease: Impact of Coronary Calcification; Elsevier Science Inc; Academic Radiology; 23; 12; 12-2016; 1490-1497
1076-6332
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.acra.2016.08.002
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1076633216301775
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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