Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography

Autores
Carrascosa, Patricia; Leipsic, Jonathon A.; Capunay, Carlos; Deviggiano, Alejandro; Vallejos, Javier; Goldsmit, Alejandro; Rodriguez Granillo, Gaston Alfredo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: To compare image interpretability and diagnostic performance of dual-energy CT coronary angiography (DE-CTCA) performed with 50% iodine load reduction versus single energy acquisitions (SE-CTCA) with full iodine load. Materials and methods: The present prospective study involved patients with suspected coronary artery disease (CAD) clinically referred for CTCA. DE-CTCA with 50% iodine volume load was performed first, and after heart rate returned to baseline SE-CTCA was performed using full iodine volume load. The primary endpoint was to compare image interpretability between groups. DE-CTCA was performed by rapid switching between low and high tube potentials (80–140 kV) from a single source, allowing the generation of monochromatic image reconstructions ranging from 40 to 140 keV. Image quality assessment was performed using a 5-point Likert scale. Results: Thirty-six patients constituted the study population. The mean heart rate before the CT scan (DE-CTCA 57.3 ± 10.7 bpm vs. SE-CTCA 58.5 ± 11.2 bpm, p = 0.29) and the mean effective radiation dose (3.5 ± 1.9 mSv vs. 3.8 ± 0.9 mSv, p = 0.48) did not differ between groups. Likert image quality scores were similar between groups (DE-CTCA 4.42 ± 0.98 vs. SE-CTCA 4.43 ± 0.84, p = 0.67). Signal-to-noise and contrast-to-noise ratios were significantly lower with DE-CTCA, driven by lower signal density levels at 60 keV compared to SE-CTCA. The sensitivity and specificity for the detection of stenosis >50% was indistinguishable between groups (DE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%); SE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%). Conclusions: In this pilot, prospective study, dual energy CTCA imaging with half iodine load achieved comparable interpretability than full iodine load with single energy CTCA.
Fil: Carrascosa, Patricia. Diagnostico Maipu; Argentina
Fil: Leipsic, Jonathon A.. St. Paul's Hospital; Canadá
Fil: Capunay, Carlos. Diagnostico Maipu; Argentina
Fil: Deviggiano, Alejandro. Diagnostico Maipu; Argentina
Fil: Vallejos, Javier. Diagnostico Maipu; Argentina
Fil: Goldsmit, Alejandro. Sanatorio Güemes; Argentina
Fil: Rodriguez Granillo, Gaston Alfredo. Diagnostico Maipu; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Atherosclerosis
Contrast Material
Coronary Artery Disease
Imaging
Volume
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39025
Acceder
id CONICETDig_f4406e270c117ead50cb5239474092dc
oai_identifier_str oai:ri.conicet.gov.ar:11336/39025
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiographyCarrascosa, PatriciaLeipsic, Jonathon A.Capunay, CarlosDeviggiano, AlejandroVallejos, JavierGoldsmit, AlejandroRodriguez Granillo, Gaston AlfredoAtherosclerosisContrast MaterialCoronary Artery DiseaseImagingVolumehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose: To compare image interpretability and diagnostic performance of dual-energy CT coronary angiography (DE-CTCA) performed with 50% iodine load reduction versus single energy acquisitions (SE-CTCA) with full iodine load. Materials and methods: The present prospective study involved patients with suspected coronary artery disease (CAD) clinically referred for CTCA. DE-CTCA with 50% iodine volume load was performed first, and after heart rate returned to baseline SE-CTCA was performed using full iodine volume load. The primary endpoint was to compare image interpretability between groups. DE-CTCA was performed by rapid switching between low and high tube potentials (80–140 kV) from a single source, allowing the generation of monochromatic image reconstructions ranging from 40 to 140 keV. Image quality assessment was performed using a 5-point Likert scale. Results: Thirty-six patients constituted the study population. The mean heart rate before the CT scan (DE-CTCA 57.3 ± 10.7 bpm vs. SE-CTCA 58.5 ± 11.2 bpm, p = 0.29) and the mean effective radiation dose (3.5 ± 1.9 mSv vs. 3.8 ± 0.9 mSv, p = 0.48) did not differ between groups. Likert image quality scores were similar between groups (DE-CTCA 4.42 ± 0.98 vs. SE-CTCA 4.43 ± 0.84, p = 0.67). Signal-to-noise and contrast-to-noise ratios were significantly lower with DE-CTCA, driven by lower signal density levels at 60 keV compared to SE-CTCA. The sensitivity and specificity for the detection of stenosis >50% was indistinguishable between groups (DE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%); SE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%). Conclusions: In this pilot, prospective study, dual energy CTCA imaging with half iodine load achieved comparable interpretability than full iodine load with single energy CTCA.Fil: Carrascosa, Patricia. Diagnostico Maipu; ArgentinaFil: Leipsic, Jonathon A.. St. Paul's Hospital; CanadáFil: Capunay, Carlos. Diagnostico Maipu; ArgentinaFil: Deviggiano, Alejandro. Diagnostico Maipu; ArgentinaFil: Vallejos, Javier. Diagnostico Maipu; ArgentinaFil: Goldsmit, Alejandro. Sanatorio Güemes; ArgentinaFil: Rodriguez Granillo, Gaston Alfredo. Diagnostico Maipu; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Ireland2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/39025Carrascosa, Patricia; Leipsic, Jonathon A.; Capunay, Carlos; Deviggiano, Alejandro; Vallejos, Javier; et al.; Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography; Elsevier Ireland; European Journal Of Radiology; 84; 10; 10-2015; 1915-19200720-048XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejrad.2015.06.019info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0720048X15300267info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:44:36Zoai:ri.conicet.gov.ar:11336/39025instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:44:36.842CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
title Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
spellingShingle Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
Carrascosa, Patricia
Atherosclerosis
Contrast Material
Coronary Artery Disease
Imaging
Volume
title_short Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
title_full Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
title_fullStr Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
title_full_unstemmed Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
title_sort Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography
dc.creator.none.fl_str_mv Carrascosa, Patricia
Leipsic, Jonathon A.
Capunay, Carlos
Deviggiano, Alejandro
Vallejos, Javier
Goldsmit, Alejandro
Rodriguez Granillo, Gaston Alfredo
author Carrascosa, Patricia
author_facet Carrascosa, Patricia
Leipsic, Jonathon A.
Capunay, Carlos
Deviggiano, Alejandro
Vallejos, Javier
Goldsmit, Alejandro
Rodriguez Granillo, Gaston Alfredo
author_role author
author2 Leipsic, Jonathon A.
Capunay, Carlos
Deviggiano, Alejandro
Vallejos, Javier
Goldsmit, Alejandro
Rodriguez Granillo, Gaston Alfredo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Atherosclerosis
Contrast Material
Coronary Artery Disease
Imaging
Volume
topic Atherosclerosis
Contrast Material
Coronary Artery Disease
Imaging
Volume
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: To compare image interpretability and diagnostic performance of dual-energy CT coronary angiography (DE-CTCA) performed with 50% iodine load reduction versus single energy acquisitions (SE-CTCA) with full iodine load. Materials and methods: The present prospective study involved patients with suspected coronary artery disease (CAD) clinically referred for CTCA. DE-CTCA with 50% iodine volume load was performed first, and after heart rate returned to baseline SE-CTCA was performed using full iodine volume load. The primary endpoint was to compare image interpretability between groups. DE-CTCA was performed by rapid switching between low and high tube potentials (80–140 kV) from a single source, allowing the generation of monochromatic image reconstructions ranging from 40 to 140 keV. Image quality assessment was performed using a 5-point Likert scale. Results: Thirty-six patients constituted the study population. The mean heart rate before the CT scan (DE-CTCA 57.3 ± 10.7 bpm vs. SE-CTCA 58.5 ± 11.2 bpm, p = 0.29) and the mean effective radiation dose (3.5 ± 1.9 mSv vs. 3.8 ± 0.9 mSv, p = 0.48) did not differ between groups. Likert image quality scores were similar between groups (DE-CTCA 4.42 ± 0.98 vs. SE-CTCA 4.43 ± 0.84, p = 0.67). Signal-to-noise and contrast-to-noise ratios were significantly lower with DE-CTCA, driven by lower signal density levels at 60 keV compared to SE-CTCA. The sensitivity and specificity for the detection of stenosis >50% was indistinguishable between groups (DE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%); SE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%). Conclusions: In this pilot, prospective study, dual energy CTCA imaging with half iodine load achieved comparable interpretability than full iodine load with single energy CTCA.
Fil: Carrascosa, Patricia. Diagnostico Maipu; Argentina
Fil: Leipsic, Jonathon A.. St. Paul's Hospital; Canadá
Fil: Capunay, Carlos. Diagnostico Maipu; Argentina
Fil: Deviggiano, Alejandro. Diagnostico Maipu; Argentina
Fil: Vallejos, Javier. Diagnostico Maipu; Argentina
Fil: Goldsmit, Alejandro. Sanatorio Güemes; Argentina
Fil: Rodriguez Granillo, Gaston Alfredo. Diagnostico Maipu; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Purpose: To compare image interpretability and diagnostic performance of dual-energy CT coronary angiography (DE-CTCA) performed with 50% iodine load reduction versus single energy acquisitions (SE-CTCA) with full iodine load. Materials and methods: The present prospective study involved patients with suspected coronary artery disease (CAD) clinically referred for CTCA. DE-CTCA with 50% iodine volume load was performed first, and after heart rate returned to baseline SE-CTCA was performed using full iodine volume load. The primary endpoint was to compare image interpretability between groups. DE-CTCA was performed by rapid switching between low and high tube potentials (80–140 kV) from a single source, allowing the generation of monochromatic image reconstructions ranging from 40 to 140 keV. Image quality assessment was performed using a 5-point Likert scale. Results: Thirty-six patients constituted the study population. The mean heart rate before the CT scan (DE-CTCA 57.3 ± 10.7 bpm vs. SE-CTCA 58.5 ± 11.2 bpm, p = 0.29) and the mean effective radiation dose (3.5 ± 1.9 mSv vs. 3.8 ± 0.9 mSv, p = 0.48) did not differ between groups. Likert image quality scores were similar between groups (DE-CTCA 4.42 ± 0.98 vs. SE-CTCA 4.43 ± 0.84, p = 0.67). Signal-to-noise and contrast-to-noise ratios were significantly lower with DE-CTCA, driven by lower signal density levels at 60 keV compared to SE-CTCA. The sensitivity and specificity for the detection of stenosis >50% was indistinguishable between groups (DE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%); SE-CTCA 84.4% (69.9–93.0%), 87.1% (81.6–91.2%). Conclusions: In this pilot, prospective study, dual energy CTCA imaging with half iodine load achieved comparable interpretability than full iodine load with single energy CTCA.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39025
Carrascosa, Patricia; Leipsic, Jonathon A.; Capunay, Carlos; Deviggiano, Alejandro; Vallejos, Javier; et al.; Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography; Elsevier Ireland; European Journal Of Radiology; 84; 10; 10-2015; 1915-1920
0720-048X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39025
identifier_str_mv Carrascosa, Patricia; Leipsic, Jonathon A.; Capunay, Carlos; Deviggiano, Alejandro; Vallejos, Javier; et al.; Monochromatic image reconstruction by dual energy imaging allows half iodine load computed tomography coronary angiography; Elsevier Ireland; European Journal Of Radiology; 84; 10; 10-2015; 1915-1920
0720-048X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejrad.2015.06.019
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0720048X15300267
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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