Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?

Autores
Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Bruining, Nico
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Coronary artery calcification (CAC) has been strongly established as an independent predictor of adverse events, with a significant incremental prognostic value over traditional risk stratification algorithms. CAC progression has been associated with a higher rate of events. In parallel, several randomized studies and meta-analysis have shown the effectiveness of statins to slow progression and even promote plaque regression. However, evidence regarding the effect of routine medical therapy on CAC has yielded conflicting results, with initial studies showing significant CAC regression, and contemporaneous data showing rather the opposite. Accordingly, there is currently a great controversy on whether progression of CAC is a sign of progression or stabilization of coronary artery disease (CAD). The finding of inexorable CAC progression despite the implementation of intensive contemporaneous medical therapy suggests that further understanding of this phenomenon should be undertaken before the implementation of CAC as a surrogate endpoint for longitudinal studies, or for prospective follow-up of patients under routine medical treatment.
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; Argentina
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina
Fil: Bruining, Nico. Erasmus MC; Países Bajos
Materia
Prognostic value
Longitudinal studies
Atherothrombosis
Imaging
Statin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41811
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?Rodriguez Granillo, Gaston AlfredoCarrascosa, PatriciaBruining, NicoPrognostic valueLongitudinal studiesAtherothrombosisImagingStatinhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Coronary artery calcification (CAC) has been strongly established as an independent predictor of adverse events, with a significant incremental prognostic value over traditional risk stratification algorithms. CAC progression has been associated with a higher rate of events. In parallel, several randomized studies and meta-analysis have shown the effectiveness of statins to slow progression and even promote plaque regression. However, evidence regarding the effect of routine medical therapy on CAC has yielded conflicting results, with initial studies showing significant CAC regression, and contemporaneous data showing rather the opposite. Accordingly, there is currently a great controversy on whether progression of CAC is a sign of progression or stabilization of coronary artery disease (CAD). The finding of inexorable CAC progression despite the implementation of intensive contemporaneous medical therapy suggests that further understanding of this phenomenon should be undertaken before the implementation of CAC as a surrogate endpoint for longitudinal studies, or for prospective follow-up of patients under routine medical treatment.Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; ArgentinaFil: Carrascosa, Patricia. Diagnóstico Maipú; ArgentinaFil: Bruining, Nico. Erasmus MC; Países BajosAME Publishing Company2016-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41811Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Bruining, Nico; Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?; AME Publishing Company; Cardiovascular Diagnosis and Therapy; 6; 3; 6-2016; 250-2582223-3660CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://cdt.amegroups.com/article/view/9556/10965info:eu-repo/semantics/altIdentifier/doi/10.21037/cdt.2016.03.03info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:59:26Zoai:ri.conicet.gov.ar:11336/41811instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:59:26.414CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
title Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
spellingShingle Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
Rodriguez Granillo, Gaston Alfredo
Prognostic value
Longitudinal studies
Atherothrombosis
Imaging
Statin
title_short Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
title_full Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
title_fullStr Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
title_full_unstemmed Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
title_sort Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
dc.creator.none.fl_str_mv Rodriguez Granillo, Gaston Alfredo
Carrascosa, Patricia
Bruining, Nico
author Rodriguez Granillo, Gaston Alfredo
author_facet Rodriguez Granillo, Gaston Alfredo
Carrascosa, Patricia
Bruining, Nico
author_role author
author2 Carrascosa, Patricia
Bruining, Nico
author2_role author
author
dc.subject.none.fl_str_mv Prognostic value
Longitudinal studies
Atherothrombosis
Imaging
Statin
topic Prognostic value
Longitudinal studies
Atherothrombosis
Imaging
Statin
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Coronary artery calcification (CAC) has been strongly established as an independent predictor of adverse events, with a significant incremental prognostic value over traditional risk stratification algorithms. CAC progression has been associated with a higher rate of events. In parallel, several randomized studies and meta-analysis have shown the effectiveness of statins to slow progression and even promote plaque regression. However, evidence regarding the effect of routine medical therapy on CAC has yielded conflicting results, with initial studies showing significant CAC regression, and contemporaneous data showing rather the opposite. Accordingly, there is currently a great controversy on whether progression of CAC is a sign of progression or stabilization of coronary artery disease (CAD). The finding of inexorable CAC progression despite the implementation of intensive contemporaneous medical therapy suggests that further understanding of this phenomenon should be undertaken before the implementation of CAC as a surrogate endpoint for longitudinal studies, or for prospective follow-up of patients under routine medical treatment.
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; Argentina
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina
Fil: Bruining, Nico. Erasmus MC; Países Bajos
description Coronary artery calcification (CAC) has been strongly established as an independent predictor of adverse events, with a significant incremental prognostic value over traditional risk stratification algorithms. CAC progression has been associated with a higher rate of events. In parallel, several randomized studies and meta-analysis have shown the effectiveness of statins to slow progression and even promote plaque regression. However, evidence regarding the effect of routine medical therapy on CAC has yielded conflicting results, with initial studies showing significant CAC regression, and contemporaneous data showing rather the opposite. Accordingly, there is currently a great controversy on whether progression of CAC is a sign of progression or stabilization of coronary artery disease (CAD). The finding of inexorable CAC progression despite the implementation of intensive contemporaneous medical therapy suggests that further understanding of this phenomenon should be undertaken before the implementation of CAC as a surrogate endpoint for longitudinal studies, or for prospective follow-up of patients under routine medical treatment.
publishDate 2016
dc.date.none.fl_str_mv 2016-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41811
Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Bruining, Nico; Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?; AME Publishing Company; Cardiovascular Diagnosis and Therapy; 6; 3; 6-2016; 250-258
2223-3660
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41811
identifier_str_mv Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Bruining, Nico; Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?; AME Publishing Company; Cardiovascular Diagnosis and Therapy; 6; 3; 6-2016; 250-258
2223-3660
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://cdt.amegroups.com/article/view/9556/10965
info:eu-repo/semantics/altIdentifier/doi/10.21037/cdt.2016.03.03
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AME Publishing Company
publisher.none.fl_str_mv AME Publishing Company
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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