Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome

Autores
Degrave, Valentina María; Vega Joubert, Michelle Berenice; Vaccarini, Cristian Adrián; Sedan, Daniela Yazmine; Andrinolo, Dario; D'alessandro, Maria Eugenia Guadalupe; Olivari, María Eugenia
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: The aim of the present study was to analyse the effects of cannabis oil on cannabinoid-inducedtetrad, blood pressure, and metabolic parameters in rats normal fed a sucrose-rich diet (SRD).Methods: Male Wistar rats were fed the following diets for 21 days: Reference Diet (RD): standardcommercial laboratory diet, SRD and SRD+Cannabis oil (SRD+Ca): the oral administration of 1 mg/kg ofbody weight of cannabis oil daily. Cannabis oil present a total cannabinoids CBD:THC 2:1 ratio. Duringthe experimental period, body weight, food intake, blood pressure, body temperature, locomotion, catalepsyand analgesia were evaluated. At the end of the experimental period, levels of glucose, triglycerides,cholesterol, uric acid, AST, ALT and AP in serum were evaluated. In liver were determined AST, ALT andAP enzymes and triglycerides and cholesterol content.Results: A cannabis oil administration significantly increased (P<0.05) analgesia, and locomotion was alsosignificantly decreased, which was found to be increased in the SRD group. Systolic and diastolic bloodpressure decreased during the experiment. In the SRD+Ca group, serum triglycerides and cholesterol levelssignificantly decreased, reaching values similar to RD group, without changes in glucose levels. In addition,serum uric acid and AP levels significantly decreased, although did not obtain reference values. AST andALT levels in serum and liver significantly decreased, reaching reference values. At the liver, thetriglycerides and cholesterol content significantly decreased with the administration of cannabis oil,although not reaching to reference values.Conclusions: Our results suggest that cannabis oil could be useful as a therapeutic strategy to prevent someof the alterations present in Metabolic Syndrome, including hypertension, dyslipidemia and liver damage.In addition, the analgesic effect of cannabis oil could be observed in SRD-fed rats.
Fil: Degrave, Valentina María. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Vega Joubert, Michelle Berenice. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Olivari, María Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Materia
CANNABIS OIL
CANNABINOID-INDUCED TETRAD
BLOOD PRESSURE
METABOLIC PARAMETERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/231397
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/231397
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic SyndromeDegrave, Valentina MaríaVega Joubert, Michelle BereniceVaccarini, Cristian AdriánSedan, Daniela YazmineAndrinolo, DarioD'alessandro, Maria Eugenia GuadalupeOlivari, María EugeniaCANNABIS OILCANNABINOID-INDUCED TETRADBLOOD PRESSUREMETABOLIC PARAMETERShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objective: The aim of the present study was to analyse the effects of cannabis oil on cannabinoid-inducedtetrad, blood pressure, and metabolic parameters in rats normal fed a sucrose-rich diet (SRD).Methods: Male Wistar rats were fed the following diets for 21 days: Reference Diet (RD): standardcommercial laboratory diet, SRD and SRD+Cannabis oil (SRD+Ca): the oral administration of 1 mg/kg ofbody weight of cannabis oil daily. Cannabis oil present a total cannabinoids CBD:THC 2:1 ratio. Duringthe experimental period, body weight, food intake, blood pressure, body temperature, locomotion, catalepsyand analgesia were evaluated. At the end of the experimental period, levels of glucose, triglycerides,cholesterol, uric acid, AST, ALT and AP in serum were evaluated. In liver were determined AST, ALT andAP enzymes and triglycerides and cholesterol content.Results: A cannabis oil administration significantly increased (P<0.05) analgesia, and locomotion was alsosignificantly decreased, which was found to be increased in the SRD group. Systolic and diastolic bloodpressure decreased during the experiment. In the SRD+Ca group, serum triglycerides and cholesterol levelssignificantly decreased, reaching values similar to RD group, without changes in glucose levels. In addition,serum uric acid and AP levels significantly decreased, although did not obtain reference values. AST andALT levels in serum and liver significantly decreased, reaching reference values. At the liver, thetriglycerides and cholesterol content significantly decreased with the administration of cannabis oil,although not reaching to reference values.Conclusions: Our results suggest that cannabis oil could be useful as a therapeutic strategy to prevent someof the alterations present in Metabolic Syndrome, including hypertension, dyslipidemia and liver damage.In addition, the analgesic effect of cannabis oil could be observed in SRD-fed rats.Fil: Degrave, Valentina María. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Vega Joubert, Michelle Berenice. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Olivari, María Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaScience Repository2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/231397Degrave, Valentina María; Vega Joubert, Michelle Berenice; Vaccarini, Cristian Adrián; Sedan, Daniela Yazmine; Andrinolo, Dario; et al.; Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome; Science Repository; Journal of Food Nutrition and Metabolism; 6; 1; 4-2023; 2-92674-2411CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencerepository.org/effects-of-cannabis-oil-on-cannabinoid_JFNM-2023-1-101info:eu-repo/semantics/altIdentifier/doi/10.31487/j.JFNM.2023.01.01info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:49Zoai:ri.conicet.gov.ar:11336/231397instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:49.797CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome
title Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome
spellingShingle Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome
Degrave, Valentina María
CANNABIS OIL
CANNABINOID-INDUCED TETRAD
BLOOD PRESSURE
METABOLIC PARAMETERS
title_short Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome
title_full Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome
title_fullStr Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome
title_full_unstemmed Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome
title_sort Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome
dc.creator.none.fl_str_mv Degrave, Valentina María
Vega Joubert, Michelle Berenice
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Dario
D'alessandro, Maria Eugenia Guadalupe
Olivari, María Eugenia
author Degrave, Valentina María
author_facet Degrave, Valentina María
Vega Joubert, Michelle Berenice
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Dario
D'alessandro, Maria Eugenia Guadalupe
Olivari, María Eugenia
author_role author
author2 Vega Joubert, Michelle Berenice
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Dario
D'alessandro, Maria Eugenia Guadalupe
Olivari, María Eugenia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CANNABIS OIL
CANNABINOID-INDUCED TETRAD
BLOOD PRESSURE
METABOLIC PARAMETERS
topic CANNABIS OIL
CANNABINOID-INDUCED TETRAD
BLOOD PRESSURE
METABOLIC PARAMETERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objective: The aim of the present study was to analyse the effects of cannabis oil on cannabinoid-inducedtetrad, blood pressure, and metabolic parameters in rats normal fed a sucrose-rich diet (SRD).Methods: Male Wistar rats were fed the following diets for 21 days: Reference Diet (RD): standardcommercial laboratory diet, SRD and SRD+Cannabis oil (SRD+Ca): the oral administration of 1 mg/kg ofbody weight of cannabis oil daily. Cannabis oil present a total cannabinoids CBD:THC 2:1 ratio. Duringthe experimental period, body weight, food intake, blood pressure, body temperature, locomotion, catalepsyand analgesia were evaluated. At the end of the experimental period, levels of glucose, triglycerides,cholesterol, uric acid, AST, ALT and AP in serum were evaluated. In liver were determined AST, ALT andAP enzymes and triglycerides and cholesterol content.Results: A cannabis oil administration significantly increased (P<0.05) analgesia, and locomotion was alsosignificantly decreased, which was found to be increased in the SRD group. Systolic and diastolic bloodpressure decreased during the experiment. In the SRD+Ca group, serum triglycerides and cholesterol levelssignificantly decreased, reaching values similar to RD group, without changes in glucose levels. In addition,serum uric acid and AP levels significantly decreased, although did not obtain reference values. AST andALT levels in serum and liver significantly decreased, reaching reference values. At the liver, thetriglycerides and cholesterol content significantly decreased with the administration of cannabis oil,although not reaching to reference values.Conclusions: Our results suggest that cannabis oil could be useful as a therapeutic strategy to prevent someof the alterations present in Metabolic Syndrome, including hypertension, dyslipidemia and liver damage.In addition, the analgesic effect of cannabis oil could be observed in SRD-fed rats.
Fil: Degrave, Valentina María. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Vega Joubert, Michelle Berenice. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Olivari, María Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
description Objective: The aim of the present study was to analyse the effects of cannabis oil on cannabinoid-inducedtetrad, blood pressure, and metabolic parameters in rats normal fed a sucrose-rich diet (SRD).Methods: Male Wistar rats were fed the following diets for 21 days: Reference Diet (RD): standardcommercial laboratory diet, SRD and SRD+Cannabis oil (SRD+Ca): the oral administration of 1 mg/kg ofbody weight of cannabis oil daily. Cannabis oil present a total cannabinoids CBD:THC 2:1 ratio. Duringthe experimental period, body weight, food intake, blood pressure, body temperature, locomotion, catalepsyand analgesia were evaluated. At the end of the experimental period, levels of glucose, triglycerides,cholesterol, uric acid, AST, ALT and AP in serum were evaluated. In liver were determined AST, ALT andAP enzymes and triglycerides and cholesterol content.Results: A cannabis oil administration significantly increased (P<0.05) analgesia, and locomotion was alsosignificantly decreased, which was found to be increased in the SRD group. Systolic and diastolic bloodpressure decreased during the experiment. In the SRD+Ca group, serum triglycerides and cholesterol levelssignificantly decreased, reaching values similar to RD group, without changes in glucose levels. In addition,serum uric acid and AP levels significantly decreased, although did not obtain reference values. AST andALT levels in serum and liver significantly decreased, reaching reference values. At the liver, thetriglycerides and cholesterol content significantly decreased with the administration of cannabis oil,although not reaching to reference values.Conclusions: Our results suggest that cannabis oil could be useful as a therapeutic strategy to prevent someof the alterations present in Metabolic Syndrome, including hypertension, dyslipidemia and liver damage.In addition, the analgesic effect of cannabis oil could be observed in SRD-fed rats.
publishDate 2023
dc.date.none.fl_str_mv 2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/231397
Degrave, Valentina María; Vega Joubert, Michelle Berenice; Vaccarini, Cristian Adrián; Sedan, Daniela Yazmine; Andrinolo, Dario; et al.; Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome; Science Repository; Journal of Food Nutrition and Metabolism; 6; 1; 4-2023; 2-9
2674-2411
CONICET Digital
CONICET
url http://hdl.handle.net/11336/231397
identifier_str_mv Degrave, Valentina María; Vega Joubert, Michelle Berenice; Vaccarini, Cristian Adrián; Sedan, Daniela Yazmine; Andrinolo, Dario; et al.; Effects of cannabis oil on cannabinoid-induced tetrad, blood pressure, and metabolic parameters in an experimental model of Metabolic Syndrome; Science Repository; Journal of Food Nutrition and Metabolism; 6; 1; 4-2023; 2-9
2674-2411
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencerepository.org/effects-of-cannabis-oil-on-cannabinoid_JFNM-2023-1-101
info:eu-repo/semantics/altIdentifier/doi/10.31487/j.JFNM.2023.01.01
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Science Repository
publisher.none.fl_str_mv Science Repository
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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