Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet

Autores
Degrave, Valentina María; Battisti, Martina; Vega Joubert, Michelle Berenice; Ingaramo, Paola Inés; Vaccarini, Cristian Adrián; Sedan, Daniela Yazmine; Andrinolo, Dario; D'alessandro, Maria Eugenia Guadalupe; Oliva, Maria Eugenia
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk ofcardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administrationon cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistarrats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oraladministration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio.Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during theexperimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serumuric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglyceridesand cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, couldbe useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect ofcannabis oil could be observed in female rats fed an SRD.
Fil: Degrave, Valentina María. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Battisti, Martina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Vega Joubert, Michelle Berenice. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Oliva, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Materia
CANNABIS OIL
FEMALE RATS
METABOLIC SYNDROME
METABOLIC PARAMETERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/225104
Acceder
id CONICETDig_55e5f10aad32d36fcdbf48cbd8eb8cfd
oai_identifier_str oai:ri.conicet.gov.ar:11336/225104
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich dietDegrave, Valentina MaríaBattisti, MartinaVega Joubert, Michelle BereniceIngaramo, Paola InésVaccarini, Cristian AdriánSedan, Daniela YazmineAndrinolo, DarioD'alessandro, Maria Eugenia GuadalupeOliva, Maria EugeniaCANNABIS OILFEMALE RATSMETABOLIC SYNDROMEMETABOLIC PARAMETERShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk ofcardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administrationon cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistarrats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oraladministration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio.Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during theexperimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serumuric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglyceridesand cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, couldbe useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect ofcannabis oil could be observed in female rats fed an SRD.Fil: Degrave, Valentina María. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Battisti, Martina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Vega Joubert, Michelle Berenice. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Oliva, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaOpen Access Text2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225104Degrave, Valentina María; Battisti, Martina; Vega Joubert, Michelle Berenice; Ingaramo, Paola Inés; Vaccarini, Cristian Adrián; et al.; Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet; Open Access Text; Integrative Food, Nutrition and Metabolism; 10; 7-2023; 1-52056-8339CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.oatext.com/cannabis-oil-effects-on-cannabinoid-induced-tetrad-blood-pressure-and-metabolic-parameters-in-female-rats-fed-a-sucrose-rich-diet.phpinfo:eu-repo/semantics/altIdentifier/doi/10.15761/IFNM.1000310info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:21Zoai:ri.conicet.gov.ar:11336/225104instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:22.052CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
spellingShingle Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
Degrave, Valentina María
CANNABIS OIL
FEMALE RATS
METABOLIC SYNDROME
METABOLIC PARAMETERS
title_short Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_full Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_fullStr Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_full_unstemmed Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_sort Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
dc.creator.none.fl_str_mv Degrave, Valentina María
Battisti, Martina
Vega Joubert, Michelle Berenice
Ingaramo, Paola Inés
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Dario
D'alessandro, Maria Eugenia Guadalupe
Oliva, Maria Eugenia
author Degrave, Valentina María
author_facet Degrave, Valentina María
Battisti, Martina
Vega Joubert, Michelle Berenice
Ingaramo, Paola Inés
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Dario
D'alessandro, Maria Eugenia Guadalupe
Oliva, Maria Eugenia
author_role author
author2 Battisti, Martina
Vega Joubert, Michelle Berenice
Ingaramo, Paola Inés
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Dario
D'alessandro, Maria Eugenia Guadalupe
Oliva, Maria Eugenia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CANNABIS OIL
FEMALE RATS
METABOLIC SYNDROME
METABOLIC PARAMETERS
topic CANNABIS OIL
FEMALE RATS
METABOLIC SYNDROME
METABOLIC PARAMETERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk ofcardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administrationon cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistarrats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oraladministration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio.Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during theexperimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serumuric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglyceridesand cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, couldbe useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect ofcannabis oil could be observed in female rats fed an SRD.
Fil: Degrave, Valentina María. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Battisti, Martina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Vega Joubert, Michelle Berenice. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: D'alessandro, Maria Eugenia Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Oliva, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
description Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk ofcardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administrationon cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistarrats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oraladministration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio.Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during theexperimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serumuric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglyceridesand cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, couldbe useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect ofcannabis oil could be observed in female rats fed an SRD.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/225104
Degrave, Valentina María; Battisti, Martina; Vega Joubert, Michelle Berenice; Ingaramo, Paola Inés; Vaccarini, Cristian Adrián; et al.; Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet; Open Access Text; Integrative Food, Nutrition and Metabolism; 10; 7-2023; 1-5
2056-8339
CONICET Digital
CONICET
url http://hdl.handle.net/11336/225104
identifier_str_mv Degrave, Valentina María; Battisti, Martina; Vega Joubert, Michelle Berenice; Ingaramo, Paola Inés; Vaccarini, Cristian Adrián; et al.; Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet; Open Access Text; Integrative Food, Nutrition and Metabolism; 10; 7-2023; 1-5
2056-8339
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.oatext.com/cannabis-oil-effects-on-cannabinoid-induced-tetrad-blood-pressure-and-metabolic-parameters-in-female-rats-fed-a-sucrose-rich-diet.php
info:eu-repo/semantics/altIdentifier/doi/10.15761/IFNM.1000310
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Open Access Text
publisher.none.fl_str_mv Open Access Text
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269340368371712
score 13.13397

Publicaciones similares