Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet

Autores
Degrave, V.; Battisti, M.; Vega Joubert, M.; Ingaramo, P.; Vaccarini, Cristian Adrián; Sedan, Daniela Yazmine; Andrinolo, Darío; D’Alessandro, M.; Oliva, M.E.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk of cardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administration on cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistar rats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oral administration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio. Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during the experimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serum uric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglycerides and cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, could be useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect of cannabis oil could be observed in female rats fed an SRD.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
Materia
Química
Biología
cannabis oil
female rats
Metabolic Syndrome
liver
cannabinoid-induced tetrad
blood pressure
metabolic parameters
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/160491
Acceder
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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich dietDegrave, V.Battisti, M.Vega Joubert, M.Ingaramo, P.Vaccarini, Cristian AdriánSedan, Daniela YazmineAndrinolo, DaríoD’Alessandro, M.Oliva, M.E.QuímicaBiologíacannabis oilfemale ratsMetabolic Syndromelivercannabinoid-induced tetradblood pressuremetabolic parametersMetabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk of cardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administration on cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistar rats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oral administration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio. Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during the experimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serum uric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglycerides and cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, could be useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect of cannabis oil could be observed in female rats fed an SRD.Centro de Investigación y Desarrollo en Criotecnología de Alimentos2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/160491enginfo:eu-repo/semantics/altIdentifier/issn/2056-8339info:eu-repo/semantics/altIdentifier/doi/10.15761/IFNM.1000310info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:14:00Zoai:sedici.unlp.edu.ar:10915/160491Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:14:00.561SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
spellingShingle Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
Degrave, V.
Química
Biología
cannabis oil
female rats
Metabolic Syndrome
liver
cannabinoid-induced tetrad
blood pressure
metabolic parameters
title_short Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_full Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_fullStr Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_full_unstemmed Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
title_sort Cannabis oil: Effects on Cannabinoid-Induced Tetrad, blood pressure and metabolic parameters in female rats fed a sucrose-rich diet
dc.creator.none.fl_str_mv Degrave, V.
Battisti, M.
Vega Joubert, M.
Ingaramo, P.
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Darío
D’Alessandro, M.
Oliva, M.E.
author Degrave, V.
author_facet Degrave, V.
Battisti, M.
Vega Joubert, M.
Ingaramo, P.
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Darío
D’Alessandro, M.
Oliva, M.E.
author_role author
author2 Battisti, M.
Vega Joubert, M.
Ingaramo, P.
Vaccarini, Cristian Adrián
Sedan, Daniela Yazmine
Andrinolo, Darío
D’Alessandro, M.
Oliva, M.E.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Química
Biología
cannabis oil
female rats
Metabolic Syndrome
liver
cannabinoid-induced tetrad
blood pressure
metabolic parameters
topic Química
Biología
cannabis oil
female rats
Metabolic Syndrome
liver
cannabinoid-induced tetrad
blood pressure
metabolic parameters
dc.description.none.fl_txt_mv Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk of cardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administration on cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistar rats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oral administration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio. Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during the experimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serum uric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglycerides and cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, could be useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect of cannabis oil could be observed in female rats fed an SRD.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
description Metabolic Syndrome (MS) is one of the most commonly used names for a clinical entity that brings together or associates different disorders that increase the risk of cardiovascular disease. Cannabis sativa has been used as an herbal medicine for tens of centuries. This study aimed to analyze the effects of cannabis oil administration on cannabinoid-induced tetrad, systolic and diastolic blood pressure, and metabolic parameters in normal female rats fed a sucrose-rich diet (SRD). Female Wistar rats were fed with the one of following diets for 21 days: Reference Diet (RD): standard commercial laboratory diet, SRD, and SRD+Cannabis oil (SRD+Ca): oral administration of 1 mg/kg body weight of cannabis oil daily. The full spectrum cannabis oil contains a total cannabinoid CBD:THC 2:1 ratio. Cannabis oil administration in the SRD significantly increased analgesia and decreased locomotion. Systolic and diastolic blood pressures decreased during the experimental protocol. In the SRD+Ca group, serum triglyceride levels decreased significantly, without changes in cholesterol and glucose levels. In addition, serum uric acid, AST, ALT and AP levels were significantly decreased. In the liver, the abnormalities of the histological sections observed in the SRD group and triglycerides and cholesterol content improved remarkably with the cannabis oil administration. Our results suggest that the administration of full-spectrum cannabis oil, could be useful as a strategy to prevent some of the alterations present in MS, including hypertension, dyslipidemia, and liver damage. Furthermore, the analgesic effect of cannabis oil could be observed in female rats fed an SRD.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/160491
url http://sedici.unlp.edu.ar/handle/10915/160491
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2056-8339
info:eu-repo/semantics/altIdentifier/doi/10.15761/IFNM.1000310
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
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collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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