Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice

Autores
Serrano Sponton, Lucas Ezequiel; Soria, Gonzalo Jose; Dubroqua, Sylvain; Singer, Philipp; Feldon, Joram; Gargiulo, Pascual Angel; Yee, Benjamin K.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The water maze is one of the most widely employed spatial learning paradigms in the cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) and working memory (WM) in the water maze are sequentially evaluated in the same animals. However, critical difference in the rules governing efficient escape from the water between WM and RM tests is expected to promote the adoption of incompatible mnemonic or navigational strategies. Hence, performance in a given test is likely poorer if it follows the other test instead of being conducted first. Yet, the presence of such negative transfer effects (or proactive interference) between WM and RM training in the water maze is often overlooked in the literature. To gauge whether this constitutes a serious concern, the present study determined empirically the magnitude, persistence, and directionality of the transfer effect in wild-type C57BL/6 mice. We contrasted the order of tests between two cohorts of mice. Performance between the two cohorts in the WM and RM tests were then separately compared. We showed that prior training of either test significantly reduced performance in the subsequent one. The statistical effect sizes in both directions were moderate to large. Although extended training could overcome the deficit, it could re-emerge later albeit in a more transient fashion. Whenever RM and WM water maze tests are conducted sequentially in the same animals – regardless of the test order, extra caution is necessary when interpreting the outcomes in the second test. Counterbalancing test orders between animals is recommended.
Fil: Serrano Sponton, Lucas Ezequiel. Mainz University Hospital. Department of Neurosurger; Alemania. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina
Fil: Soria, Gonzalo Jose. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina
Fil: Dubroqua, Sylvain. Institute of Brain and Cognitive Science; China. Laboratory of Behavioural Neurobiology; Suiza
Fil: Singer, Philipp. Institute of Brain and Cognitive Science; China. Roche Diagnostics; Suiza
Fil: Feldon, Joram. Laboratory of Behavioural Neurobiology; Suiza. Roche Diagnostics; Suiza
Fil: Gargiulo, Pascual Angel. Universidad Nacional de cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina
Fil: Yee, Benjamin K.. Laboratory of Behavioural Neurobiology; Suiza. The Hong Kong Polytechnic University. Faculty of Health and Social Sciences,; China
Materia
Mouse
Spatial Learning
Transfer Effect
Water Maze
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43365
Acceder
id CONICETDig_662eeadafa9ac5f1f9fe9bf796fa9d48
oai_identifier_str oai:ri.conicet.gov.ar:11336/43365
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 miceSerrano Sponton, Lucas EzequielSoria, Gonzalo JoseDubroqua, SylvainSinger, PhilippFeldon, JoramGargiulo, Pascual AngelYee, Benjamin K.MouseSpatial LearningTransfer EffectWater Mazehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The water maze is one of the most widely employed spatial learning paradigms in the cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) and working memory (WM) in the water maze are sequentially evaluated in the same animals. However, critical difference in the rules governing efficient escape from the water between WM and RM tests is expected to promote the adoption of incompatible mnemonic or navigational strategies. Hence, performance in a given test is likely poorer if it follows the other test instead of being conducted first. Yet, the presence of such negative transfer effects (or proactive interference) between WM and RM training in the water maze is often overlooked in the literature. To gauge whether this constitutes a serious concern, the present study determined empirically the magnitude, persistence, and directionality of the transfer effect in wild-type C57BL/6 mice. We contrasted the order of tests between two cohorts of mice. Performance between the two cohorts in the WM and RM tests were then separately compared. We showed that prior training of either test significantly reduced performance in the subsequent one. The statistical effect sizes in both directions were moderate to large. Although extended training could overcome the deficit, it could re-emerge later albeit in a more transient fashion. Whenever RM and WM water maze tests are conducted sequentially in the same animals – regardless of the test order, extra caution is necessary when interpreting the outcomes in the second test. Counterbalancing test orders between animals is recommended.Fil: Serrano Sponton, Lucas Ezequiel. Mainz University Hospital. Department of Neurosurger; Alemania. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Soria, Gonzalo Jose. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Dubroqua, Sylvain. Institute of Brain and Cognitive Science; China. Laboratory of Behavioural Neurobiology; SuizaFil: Singer, Philipp. Institute of Brain and Cognitive Science; China. Roche Diagnostics; SuizaFil: Feldon, Joram. Laboratory of Behavioural Neurobiology; Suiza. Roche Diagnostics; SuizaFil: Gargiulo, Pascual Angel. Universidad Nacional de cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Yee, Benjamin K.. Laboratory of Behavioural Neurobiology; Suiza. The Hong Kong Polytechnic University. Faculty of Health and Social Sciences,; ChinaElsevier Science2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43365Serrano Sponton, Lucas Ezequiel; Soria, Gonzalo Jose; Dubroqua, Sylvain; Singer, Philipp; Feldon, Joram; et al.; Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice; Elsevier Science; Behavioural Brain Research; 339; 11-2017; 268-2960166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2017.10.033info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432817312081info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:56:38Zoai:ri.conicet.gov.ar:11336/43365instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:56:39.123CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice
title Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice
spellingShingle Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice
Serrano Sponton, Lucas Ezequiel
Mouse
Spatial Learning
Transfer Effect
Water Maze
title_short Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice
title_full Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice
title_fullStr Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice
title_full_unstemmed Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice
title_sort Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice
dc.creator.none.fl_str_mv Serrano Sponton, Lucas Ezequiel
Soria, Gonzalo Jose
Dubroqua, Sylvain
Singer, Philipp
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamin K.
author Serrano Sponton, Lucas Ezequiel
author_facet Serrano Sponton, Lucas Ezequiel
Soria, Gonzalo Jose
Dubroqua, Sylvain
Singer, Philipp
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamin K.
author_role author
author2 Soria, Gonzalo Jose
Dubroqua, Sylvain
Singer, Philipp
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamin K.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Mouse
Spatial Learning
Transfer Effect
Water Maze
topic Mouse
Spatial Learning
Transfer Effect
Water Maze
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The water maze is one of the most widely employed spatial learning paradigms in the cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) and working memory (WM) in the water maze are sequentially evaluated in the same animals. However, critical difference in the rules governing efficient escape from the water between WM and RM tests is expected to promote the adoption of incompatible mnemonic or navigational strategies. Hence, performance in a given test is likely poorer if it follows the other test instead of being conducted first. Yet, the presence of such negative transfer effects (or proactive interference) between WM and RM training in the water maze is often overlooked in the literature. To gauge whether this constitutes a serious concern, the present study determined empirically the magnitude, persistence, and directionality of the transfer effect in wild-type C57BL/6 mice. We contrasted the order of tests between two cohorts of mice. Performance between the two cohorts in the WM and RM tests were then separately compared. We showed that prior training of either test significantly reduced performance in the subsequent one. The statistical effect sizes in both directions were moderate to large. Although extended training could overcome the deficit, it could re-emerge later albeit in a more transient fashion. Whenever RM and WM water maze tests are conducted sequentially in the same animals – regardless of the test order, extra caution is necessary when interpreting the outcomes in the second test. Counterbalancing test orders between animals is recommended.
Fil: Serrano Sponton, Lucas Ezequiel. Mainz University Hospital. Department of Neurosurger; Alemania. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina
Fil: Soria, Gonzalo Jose. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina
Fil: Dubroqua, Sylvain. Institute of Brain and Cognitive Science; China. Laboratory of Behavioural Neurobiology; Suiza
Fil: Singer, Philipp. Institute of Brain and Cognitive Science; China. Roche Diagnostics; Suiza
Fil: Feldon, Joram. Laboratory of Behavioural Neurobiology; Suiza. Roche Diagnostics; Suiza
Fil: Gargiulo, Pascual Angel. Universidad Nacional de cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina
Fil: Yee, Benjamin K.. Laboratory of Behavioural Neurobiology; Suiza. The Hong Kong Polytechnic University. Faculty of Health and Social Sciences,; China
description The water maze is one of the most widely employed spatial learning paradigms in the cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) and working memory (WM) in the water maze are sequentially evaluated in the same animals. However, critical difference in the rules governing efficient escape from the water between WM and RM tests is expected to promote the adoption of incompatible mnemonic or navigational strategies. Hence, performance in a given test is likely poorer if it follows the other test instead of being conducted first. Yet, the presence of such negative transfer effects (or proactive interference) between WM and RM training in the water maze is often overlooked in the literature. To gauge whether this constitutes a serious concern, the present study determined empirically the magnitude, persistence, and directionality of the transfer effect in wild-type C57BL/6 mice. We contrasted the order of tests between two cohorts of mice. Performance between the two cohorts in the WM and RM tests were then separately compared. We showed that prior training of either test significantly reduced performance in the subsequent one. The statistical effect sizes in both directions were moderate to large. Although extended training could overcome the deficit, it could re-emerge later albeit in a more transient fashion. Whenever RM and WM water maze tests are conducted sequentially in the same animals – regardless of the test order, extra caution is necessary when interpreting the outcomes in the second test. Counterbalancing test orders between animals is recommended.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43365
Serrano Sponton, Lucas Ezequiel; Soria, Gonzalo Jose; Dubroqua, Sylvain; Singer, Philipp; Feldon, Joram; et al.; Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice; Elsevier Science; Behavioural Brain Research; 339; 11-2017; 268-296
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43365
identifier_str_mv Serrano Sponton, Lucas Ezequiel; Soria, Gonzalo Jose; Dubroqua, Sylvain; Singer, Philipp; Feldon, Joram; et al.; Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice; Elsevier Science; Behavioural Brain Research; 339; 11-2017; 268-296
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2017.10.033
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432817312081
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843606231403462656
score 13.001348

Publicaciones similares