Intact working memory in the absence of forebrain neuronal glycine transporter 1

Autores
Dubroqua, Sylvain; Serrano, Lucas; Boison, Detlev; Feldon, Joram; Gargiulo, Pascual Angel; Yee, Benjamín A.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Glycine transporter 1 (GlyT1) is a potential pharmacological target to ameliorate memory deficits attributable to N-methyl-d-aspartate receptor (NMDAR) hypofunction. Disruption of glycine-reuptake near excitatory synapses is expected to enhance NMDAR function by increasing glycine-B site occupancy. Genetic models with conditional GlyT1 deletion restricted to forebrain neurons have yielded several promising promnesic effects, yet its impact on working memory function remains essentially unanswered because the previous attempt had yielded un-interpretable outcomes. The present study clarified this important outstanding lacuna using a within-subject multi-test approach. Here, a consistent lack of effects was convincingly demonstrated across three working memory tests - the radial arm maze, the cheeseboard maze, and the water maze. These null outcomes contrasted with the phenotype of enhanced working memory performance seen in mutant mice with GlyT1 deletion extended to cortical/hippocampal glial cells. It follows that glial-based GlyT1 might be more closely linked to the modulation of working memory function, and raises the possibility that neuronal and glial GlyT1 may regulate cognitive functions via dissociable mechanisms.
Fil: Dubroqua, Sylvain. Laboratory Of Behavioural Neurobiology; Suiza
Fil: Serrano, Lucas. Laboratory Of Behavioural Neurobiology; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Boison, Detlev. Dow Neurobiology Laboratories; Estados Unidos
Fil: Feldon, Joram. Laboratory Of Behavioural Neurobiology; Suiza
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Yee, Benjamín A.. Laboratory Of Behavioural Neurobiology; Suiza
Materia
Cheeseboard Maze
Glyt1
Learning
Nmda Receptor
Radial Arm Maze
Water Maze
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79066
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Intact working memory in the absence of forebrain neuronal glycine transporter 1Dubroqua, SylvainSerrano, LucasBoison, DetlevFeldon, JoramGargiulo, Pascual AngelYee, Benjamín A.Cheeseboard MazeGlyt1LearningNmda ReceptorRadial Arm MazeWater Mazehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Glycine transporter 1 (GlyT1) is a potential pharmacological target to ameliorate memory deficits attributable to N-methyl-d-aspartate receptor (NMDAR) hypofunction. Disruption of glycine-reuptake near excitatory synapses is expected to enhance NMDAR function by increasing glycine-B site occupancy. Genetic models with conditional GlyT1 deletion restricted to forebrain neurons have yielded several promising promnesic effects, yet its impact on working memory function remains essentially unanswered because the previous attempt had yielded un-interpretable outcomes. The present study clarified this important outstanding lacuna using a within-subject multi-test approach. Here, a consistent lack of effects was convincingly demonstrated across three working memory tests - the radial arm maze, the cheeseboard maze, and the water maze. These null outcomes contrasted with the phenotype of enhanced working memory performance seen in mutant mice with GlyT1 deletion extended to cortical/hippocampal glial cells. It follows that glial-based GlyT1 might be more closely linked to the modulation of working memory function, and raises the possibility that neuronal and glial GlyT1 may regulate cognitive functions via dissociable mechanisms.Fil: Dubroqua, Sylvain. Laboratory Of Behavioural Neurobiology; SuizaFil: Serrano, Lucas. Laboratory Of Behavioural Neurobiology; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Boison, Detlev. Dow Neurobiology Laboratories; Estados UnidosFil: Feldon, Joram. Laboratory Of Behavioural Neurobiology; SuizaFil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Yee, Benjamín A.. Laboratory Of Behavioural Neurobiology; SuizaElsevier Science2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79066Dubroqua, Sylvain; Serrano, Lucas; Boison, Detlev; Feldon, Joram; Gargiulo, Pascual Angel; et al.; Intact working memory in the absence of forebrain neuronal glycine transporter 1; Elsevier Science; Behavioural Brain Research; 230; 1; 4-2012; 208-2140166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2012.01.061info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432812000988info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565836/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T09:07:01Zoai:ri.conicet.gov.ar:11336/79066instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 09:07:02.113CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Intact working memory in the absence of forebrain neuronal glycine transporter 1
title Intact working memory in the absence of forebrain neuronal glycine transporter 1
spellingShingle Intact working memory in the absence of forebrain neuronal glycine transporter 1
Dubroqua, Sylvain
Cheeseboard Maze
Glyt1
Learning
Nmda Receptor
Radial Arm Maze
Water Maze
title_short Intact working memory in the absence of forebrain neuronal glycine transporter 1
title_full Intact working memory in the absence of forebrain neuronal glycine transporter 1
title_fullStr Intact working memory in the absence of forebrain neuronal glycine transporter 1
title_full_unstemmed Intact working memory in the absence of forebrain neuronal glycine transporter 1
title_sort Intact working memory in the absence of forebrain neuronal glycine transporter 1
dc.creator.none.fl_str_mv Dubroqua, Sylvain
Serrano, Lucas
Boison, Detlev
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamín A.
author Dubroqua, Sylvain
author_facet Dubroqua, Sylvain
Serrano, Lucas
Boison, Detlev
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamín A.
author_role author
author2 Serrano, Lucas
Boison, Detlev
Feldon, Joram
Gargiulo, Pascual Angel
Yee, Benjamín A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cheeseboard Maze
Glyt1
Learning
Nmda Receptor
Radial Arm Maze
Water Maze
topic Cheeseboard Maze
Glyt1
Learning
Nmda Receptor
Radial Arm Maze
Water Maze
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Glycine transporter 1 (GlyT1) is a potential pharmacological target to ameliorate memory deficits attributable to N-methyl-d-aspartate receptor (NMDAR) hypofunction. Disruption of glycine-reuptake near excitatory synapses is expected to enhance NMDAR function by increasing glycine-B site occupancy. Genetic models with conditional GlyT1 deletion restricted to forebrain neurons have yielded several promising promnesic effects, yet its impact on working memory function remains essentially unanswered because the previous attempt had yielded un-interpretable outcomes. The present study clarified this important outstanding lacuna using a within-subject multi-test approach. Here, a consistent lack of effects was convincingly demonstrated across three working memory tests - the radial arm maze, the cheeseboard maze, and the water maze. These null outcomes contrasted with the phenotype of enhanced working memory performance seen in mutant mice with GlyT1 deletion extended to cortical/hippocampal glial cells. It follows that glial-based GlyT1 might be more closely linked to the modulation of working memory function, and raises the possibility that neuronal and glial GlyT1 may regulate cognitive functions via dissociable mechanisms.
Fil: Dubroqua, Sylvain. Laboratory Of Behavioural Neurobiology; Suiza
Fil: Serrano, Lucas. Laboratory Of Behavioural Neurobiology; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Boison, Detlev. Dow Neurobiology Laboratories; Estados Unidos
Fil: Feldon, Joram. Laboratory Of Behavioural Neurobiology; Suiza
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Yee, Benjamín A.. Laboratory Of Behavioural Neurobiology; Suiza
description Glycine transporter 1 (GlyT1) is a potential pharmacological target to ameliorate memory deficits attributable to N-methyl-d-aspartate receptor (NMDAR) hypofunction. Disruption of glycine-reuptake near excitatory synapses is expected to enhance NMDAR function by increasing glycine-B site occupancy. Genetic models with conditional GlyT1 deletion restricted to forebrain neurons have yielded several promising promnesic effects, yet its impact on working memory function remains essentially unanswered because the previous attempt had yielded un-interpretable outcomes. The present study clarified this important outstanding lacuna using a within-subject multi-test approach. Here, a consistent lack of effects was convincingly demonstrated across three working memory tests - the radial arm maze, the cheeseboard maze, and the water maze. These null outcomes contrasted with the phenotype of enhanced working memory performance seen in mutant mice with GlyT1 deletion extended to cortical/hippocampal glial cells. It follows that glial-based GlyT1 might be more closely linked to the modulation of working memory function, and raises the possibility that neuronal and glial GlyT1 may regulate cognitive functions via dissociable mechanisms.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79066
Dubroqua, Sylvain; Serrano, Lucas; Boison, Detlev; Feldon, Joram; Gargiulo, Pascual Angel; et al.; Intact working memory in the absence of forebrain neuronal glycine transporter 1; Elsevier Science; Behavioural Brain Research; 230; 1; 4-2012; 208-214
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79066
identifier_str_mv Dubroqua, Sylvain; Serrano, Lucas; Boison, Detlev; Feldon, Joram; Gargiulo, Pascual Angel; et al.; Intact working memory in the absence of forebrain neuronal glycine transporter 1; Elsevier Science; Behavioural Brain Research; 230; 1; 4-2012; 208-214
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2012.01.061
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432812000988
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565836/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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