Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus

Autores
Gallucci, Mauro Nicolas; Oliva, Maria de Las Mercedes; Casero, Carina Noelia; Dambolena, José Sebastián; Luna, Agustin; Zygadlo, Julio Alberto; Demo, Mirta Susana
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aims of this work were to study the antimicrobial activity of nine monoterpenes and the synergistic or antagonistic associations between them, and to relate water solubility, H-bonding and pKa values with antimicrobial activity. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentration (MBCs) were determined. The MIC of carvacrol against S. aureus was 3.2 g/l and of thymol was 7.5 g/l. E. coli was resistant. Carvacrol and thymol were bactericidal. The associations geraniol/menthol against S. aureus and B. cereus and thymol/menthol against B. cereus were totally synergistic. Eugenol/geraniol displayed partial synergism against B. cereus. The other groups did not show any synergistic effect. Eugenol had the lowest pKa, followed by thymol and carvacrol. Eugenol had the highest total area and polar area and intermolecular and intramolecular hydrogen-bonding capacity, while carvacrol and thymol only had intermolecular hydrogenbonding capacity. The terpenes alone and in combination were effective against microorganisms. Phenolic compounds were the most active terpenes. Associations between terpenes were related to the chemical structure. Studies on the antimicrobial activity of associations of terpenes will advance the search for new alternatives for food preservation.
Fil: Gallucci, Mauro Nicolas. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Oliva, Maria de Las Mercedes. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Casero, Carina Noelia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dambolena, José Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Luna, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Demo, Mirta Susana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina
Materia
Essential Oils
Terpenes
Antibacterial Activity
Synergism
Antagonism
Hydrogen- Bonding Capacity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24585
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/24585
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereusGallucci, Mauro NicolasOliva, Maria de Las MercedesCasero, Carina NoeliaDambolena, José SebastiánLuna, AgustinZygadlo, Julio AlbertoDemo, Mirta SusanaEssential OilsTerpenesAntibacterial ActivitySynergismAntagonismHydrogen- Bonding Capacityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aims of this work were to study the antimicrobial activity of nine monoterpenes and the synergistic or antagonistic associations between them, and to relate water solubility, H-bonding and pKa values with antimicrobial activity. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentration (MBCs) were determined. The MIC of carvacrol against S. aureus was 3.2 g/l and of thymol was 7.5 g/l. E. coli was resistant. Carvacrol and thymol were bactericidal. The associations geraniol/menthol against S. aureus and B. cereus and thymol/menthol against B. cereus were totally synergistic. Eugenol/geraniol displayed partial synergism against B. cereus. The other groups did not show any synergistic effect. Eugenol had the lowest pKa, followed by thymol and carvacrol. Eugenol had the highest total area and polar area and intermolecular and intramolecular hydrogen-bonding capacity, while carvacrol and thymol only had intermolecular hydrogenbonding capacity. The terpenes alone and in combination were effective against microorganisms. Phenolic compounds were the most active terpenes. Associations between terpenes were related to the chemical structure. Studies on the antimicrobial activity of associations of terpenes will advance the search for new alternatives for food preservation.Fil: Gallucci, Mauro Nicolas. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Oliva, Maria de Las Mercedes. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Casero, Carina Noelia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dambolena, José Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Luna, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Demo, Mirta Susana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; ArgentinaWiley2009-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24585Gallucci, Mauro Nicolas; Oliva, Maria de Las Mercedes; Casero, Carina Noelia; Dambolena, José Sebastián; Luna, Agustin; et al.; Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus; Wiley; Flavour And Fragrance Journal; 24; 6; 9-2009; 348-3580882-5734CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ffj.1948info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ffj.1948/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:03:34Zoai:ri.conicet.gov.ar:11336/24585instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:03:34.281CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus
title Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus
spellingShingle Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus
Gallucci, Mauro Nicolas
Essential Oils
Terpenes
Antibacterial Activity
Synergism
Antagonism
Hydrogen- Bonding Capacity
title_short Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus
title_full Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus
title_fullStr Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus
title_full_unstemmed Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus
title_sort Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus
dc.creator.none.fl_str_mv Gallucci, Mauro Nicolas
Oliva, Maria de Las Mercedes
Casero, Carina Noelia
Dambolena, José Sebastián
Luna, Agustin
Zygadlo, Julio Alberto
Demo, Mirta Susana
author Gallucci, Mauro Nicolas
author_facet Gallucci, Mauro Nicolas
Oliva, Maria de Las Mercedes
Casero, Carina Noelia
Dambolena, José Sebastián
Luna, Agustin
Zygadlo, Julio Alberto
Demo, Mirta Susana
author_role author
author2 Oliva, Maria de Las Mercedes
Casero, Carina Noelia
Dambolena, José Sebastián
Luna, Agustin
Zygadlo, Julio Alberto
Demo, Mirta Susana
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Essential Oils
Terpenes
Antibacterial Activity
Synergism
Antagonism
Hydrogen- Bonding Capacity
topic Essential Oils
Terpenes
Antibacterial Activity
Synergism
Antagonism
Hydrogen- Bonding Capacity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aims of this work were to study the antimicrobial activity of nine monoterpenes and the synergistic or antagonistic associations between them, and to relate water solubility, H-bonding and pKa values with antimicrobial activity. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentration (MBCs) were determined. The MIC of carvacrol against S. aureus was 3.2 g/l and of thymol was 7.5 g/l. E. coli was resistant. Carvacrol and thymol were bactericidal. The associations geraniol/menthol against S. aureus and B. cereus and thymol/menthol against B. cereus were totally synergistic. Eugenol/geraniol displayed partial synergism against B. cereus. The other groups did not show any synergistic effect. Eugenol had the lowest pKa, followed by thymol and carvacrol. Eugenol had the highest total area and polar area and intermolecular and intramolecular hydrogen-bonding capacity, while carvacrol and thymol only had intermolecular hydrogenbonding capacity. The terpenes alone and in combination were effective against microorganisms. Phenolic compounds were the most active terpenes. Associations between terpenes were related to the chemical structure. Studies on the antimicrobial activity of associations of terpenes will advance the search for new alternatives for food preservation.
Fil: Gallucci, Mauro Nicolas. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Oliva, Maria de Las Mercedes. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Casero, Carina Noelia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dambolena, José Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Luna, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Demo, Mirta Susana. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina
description The aims of this work were to study the antimicrobial activity of nine monoterpenes and the synergistic or antagonistic associations between them, and to relate water solubility, H-bonding and pKa values with antimicrobial activity. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentration (MBCs) were determined. The MIC of carvacrol against S. aureus was 3.2 g/l and of thymol was 7.5 g/l. E. coli was resistant. Carvacrol and thymol were bactericidal. The associations geraniol/menthol against S. aureus and B. cereus and thymol/menthol against B. cereus were totally synergistic. Eugenol/geraniol displayed partial synergism against B. cereus. The other groups did not show any synergistic effect. Eugenol had the lowest pKa, followed by thymol and carvacrol. Eugenol had the highest total area and polar area and intermolecular and intramolecular hydrogen-bonding capacity, while carvacrol and thymol only had intermolecular hydrogenbonding capacity. The terpenes alone and in combination were effective against microorganisms. Phenolic compounds were the most active terpenes. Associations between terpenes were related to the chemical structure. Studies on the antimicrobial activity of associations of terpenes will advance the search for new alternatives for food preservation.
publishDate 2009
dc.date.none.fl_str_mv 2009-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24585
Gallucci, Mauro Nicolas; Oliva, Maria de Las Mercedes; Casero, Carina Noelia; Dambolena, José Sebastián; Luna, Agustin; et al.; Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus; Wiley; Flavour And Fragrance Journal; 24; 6; 9-2009; 348-358
0882-5734
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24585
identifier_str_mv Gallucci, Mauro Nicolas; Oliva, Maria de Las Mercedes; Casero, Carina Noelia; Dambolena, José Sebastián; Luna, Agustin; et al.; Antimicrobial combined action of terpenes against the food-borne microorganisms Escherichia coli, Staphylococcus aureus and Bacillus cereus; Wiley; Flavour And Fragrance Journal; 24; 6; 9-2009; 348-358
0882-5734
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/ffj.1948
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ffj.1948/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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