Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate

Autores
Capozza, Ricardo Francisco; Mondelo, N.; Reina, Paola Soledad; Nocciolino, Laura Marcela; Meta, M.; Roldán, E. J. L.; Ferretti, Jose Luis; Cointry, Gustavo Roberto
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Some pharmacologic effects on bone modeling may not be evident in studies of remodeling skeletons. This study analyzes some effects of olpadronate on cortical bone modeling and post-yield properties in femurs diaphyses (virtually only-modeling bones) of young rats by mid-diaphyseal pQCT scans and bending tests. We studied 20/22 male/female animals traetad orally with olpadronate (45-90 mg/kg/d, 3 months) and 8/9 untreated controls. Both OPD doses enhanced diaphyseal cross-sectional moments of inertia (CSMI) with no change in cortical vBMD and elastic modulus. Yield stiffness and strength were mildly increased. Postyield strength, deflection and energy absorption were strikingly enhanced. Ultimate strength was enhanced mainly because of effects on bone mass/geometry and post-yield properties. The large improvement of post-yield properties could be explained by improvements in bone geometry. Improvements in bone mass/geometry over weight-bearing needs suggest an enhanced modeling-related response to mechanical stimuli. Effects on tissue microstructural factors (not measured) could not be excluded. Results reveal novel olpadronate effects on bone strength and toughness unrelated to tissue mineralization and stiffness, even at high doses. Further studies could establish whether this could also occur in modeling-remodeling skeletons. If so, they could counteract the negative impact of anti-remodeling effects of bisphosphonates on bone strength.
Fil: Capozza, Ricardo Francisco. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mondelo, N.. Gador; Argentina
Fil: Reina, Paola Soledad. Universidad Nacional de Rosario; Argentina
Fil: Nocciolino, Laura Marcela. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Meta, M.. Universidad Nacional de Rosario; Argentina
Fil: Roldán, E. J. L.. Gador; Argentina
Fil: Ferretti, Jose Luis. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Bisphosphonates
Olpadronate
Bone Biomechanics
Peripheral Qct (Pqct)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21841
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronateCapozza, Ricardo FranciscoMondelo, N.Reina, Paola SoledadNocciolino, Laura MarcelaMeta, M.Roldán, E. J. L.Ferretti, Jose LuisCointry, Gustavo RobertoBisphosphonatesOlpadronateBone BiomechanicsPeripheral Qct (Pqct)https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Some pharmacologic effects on bone modeling may not be evident in studies of remodeling skeletons. This study analyzes some effects of olpadronate on cortical bone modeling and post-yield properties in femurs diaphyses (virtually only-modeling bones) of young rats by mid-diaphyseal pQCT scans and bending tests. We studied 20/22 male/female animals traetad orally with olpadronate (45-90 mg/kg/d, 3 months) and 8/9 untreated controls. Both OPD doses enhanced diaphyseal cross-sectional moments of inertia (CSMI) with no change in cortical vBMD and elastic modulus. Yield stiffness and strength were mildly increased. Postyield strength, deflection and energy absorption were strikingly enhanced. Ultimate strength was enhanced mainly because of effects on bone mass/geometry and post-yield properties. The large improvement of post-yield properties could be explained by improvements in bone geometry. Improvements in bone mass/geometry over weight-bearing needs suggest an enhanced modeling-related response to mechanical stimuli. Effects on tissue microstructural factors (not measured) could not be excluded. Results reveal novel olpadronate effects on bone strength and toughness unrelated to tissue mineralization and stiffness, even at high doses. Further studies could establish whether this could also occur in modeling-remodeling skeletons. If so, they could counteract the negative impact of anti-remodeling effects of bisphosphonates on bone strength.Fil: Capozza, Ricardo Francisco. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mondelo, N.. Gador; ArgentinaFil: Reina, Paola Soledad. Universidad Nacional de Rosario; ArgentinaFil: Nocciolino, Laura Marcela. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Meta, M.. Universidad Nacional de Rosario; ArgentinaFil: Roldán, E. J. L.. Gador; ArgentinaFil: Ferretti, Jose Luis. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaInternational Society of Musculoskeletal and Neuronal Interactions2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21841Capozza, Ricardo Francisco; Mondelo, N.; Reina, Paola Soledad; Nocciolino, Laura Marcela; Meta, M.; et al.; Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate; International Society of Musculoskeletal and Neuronal Interactions; Journal of Musculoskeletal & Neuronal Interactions; 13; 2; 6-2013; 185-1941108-7161CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ismni.org/jmni/Archive.php?year=2013#v13i2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:48Zoai:ri.conicet.gov.ar:11336/21841instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:48.537CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate
title Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate
spellingShingle Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate
Capozza, Ricardo Francisco
Bisphosphonates
Olpadronate
Bone Biomechanics
Peripheral Qct (Pqct)
title_short Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate
title_full Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate
title_fullStr Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate
title_full_unstemmed Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate
title_sort Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate
dc.creator.none.fl_str_mv Capozza, Ricardo Francisco
Mondelo, N.
Reina, Paola Soledad
Nocciolino, Laura Marcela
Meta, M.
Roldán, E. J. L.
Ferretti, Jose Luis
Cointry, Gustavo Roberto
author Capozza, Ricardo Francisco
author_facet Capozza, Ricardo Francisco
Mondelo, N.
Reina, Paola Soledad
Nocciolino, Laura Marcela
Meta, M.
Roldán, E. J. L.
Ferretti, Jose Luis
Cointry, Gustavo Roberto
author_role author
author2 Mondelo, N.
Reina, Paola Soledad
Nocciolino, Laura Marcela
Meta, M.
Roldán, E. J. L.
Ferretti, Jose Luis
Cointry, Gustavo Roberto
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bisphosphonates
Olpadronate
Bone Biomechanics
Peripheral Qct (Pqct)
topic Bisphosphonates
Olpadronate
Bone Biomechanics
Peripheral Qct (Pqct)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Some pharmacologic effects on bone modeling may not be evident in studies of remodeling skeletons. This study analyzes some effects of olpadronate on cortical bone modeling and post-yield properties in femurs diaphyses (virtually only-modeling bones) of young rats by mid-diaphyseal pQCT scans and bending tests. We studied 20/22 male/female animals traetad orally with olpadronate (45-90 mg/kg/d, 3 months) and 8/9 untreated controls. Both OPD doses enhanced diaphyseal cross-sectional moments of inertia (CSMI) with no change in cortical vBMD and elastic modulus. Yield stiffness and strength were mildly increased. Postyield strength, deflection and energy absorption were strikingly enhanced. Ultimate strength was enhanced mainly because of effects on bone mass/geometry and post-yield properties. The large improvement of post-yield properties could be explained by improvements in bone geometry. Improvements in bone mass/geometry over weight-bearing needs suggest an enhanced modeling-related response to mechanical stimuli. Effects on tissue microstructural factors (not measured) could not be excluded. Results reveal novel olpadronate effects on bone strength and toughness unrelated to tissue mineralization and stiffness, even at high doses. Further studies could establish whether this could also occur in modeling-remodeling skeletons. If so, they could counteract the negative impact of anti-remodeling effects of bisphosphonates on bone strength.
Fil: Capozza, Ricardo Francisco. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mondelo, N.. Gador; Argentina
Fil: Reina, Paola Soledad. Universidad Nacional de Rosario; Argentina
Fil: Nocciolino, Laura Marcela. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Meta, M.. Universidad Nacional de Rosario; Argentina
Fil: Roldán, E. J. L.. Gador; Argentina
Fil: Ferretti, Jose Luis. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cointry, Gustavo Roberto. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Some pharmacologic effects on bone modeling may not be evident in studies of remodeling skeletons. This study analyzes some effects of olpadronate on cortical bone modeling and post-yield properties in femurs diaphyses (virtually only-modeling bones) of young rats by mid-diaphyseal pQCT scans and bending tests. We studied 20/22 male/female animals traetad orally with olpadronate (45-90 mg/kg/d, 3 months) and 8/9 untreated controls. Both OPD doses enhanced diaphyseal cross-sectional moments of inertia (CSMI) with no change in cortical vBMD and elastic modulus. Yield stiffness and strength were mildly increased. Postyield strength, deflection and energy absorption were strikingly enhanced. Ultimate strength was enhanced mainly because of effects on bone mass/geometry and post-yield properties. The large improvement of post-yield properties could be explained by improvements in bone geometry. Improvements in bone mass/geometry over weight-bearing needs suggest an enhanced modeling-related response to mechanical stimuli. Effects on tissue microstructural factors (not measured) could not be excluded. Results reveal novel olpadronate effects on bone strength and toughness unrelated to tissue mineralization and stiffness, even at high doses. Further studies could establish whether this could also occur in modeling-remodeling skeletons. If so, they could counteract the negative impact of anti-remodeling effects of bisphosphonates on bone strength.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21841
Capozza, Ricardo Francisco; Mondelo, N.; Reina, Paola Soledad; Nocciolino, Laura Marcela; Meta, M.; et al.; Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate; International Society of Musculoskeletal and Neuronal Interactions; Journal of Musculoskeletal & Neuronal Interactions; 13; 2; 6-2013; 185-194
1108-7161
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21841
identifier_str_mv Capozza, Ricardo Francisco; Mondelo, N.; Reina, Paola Soledad; Nocciolino, Laura Marcela; Meta, M.; et al.; Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate; International Society of Musculoskeletal and Neuronal Interactions; Journal of Musculoskeletal & Neuronal Interactions; 13; 2; 6-2013; 185-194
1108-7161
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ismni.org/jmni/Archive.php?year=2013#v13i2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Society of Musculoskeletal and Neuronal Interactions
publisher.none.fl_str_mv International Society of Musculoskeletal and Neuronal Interactions
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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