Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases

Autores
Mackern Oberti, Juan Pablo; Llanos, Carolina; Vega, Fabián; Salazar Onfray, Flavio; Riedel, Claudia A.; Bueno, Mirian Susana; Kalergis, Alexis
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory receptors expressed on the surface of DCs has been linked to increased susceptibility to develop autoimmune diseases underscoring their immunogenicity potential. It has been described that modulation of activating or inhibitory molecules expressed by DCs, such as CD86, TLRs, PDL-1 and FcγRs, can define the immunogenic phenotype. On the other hand, T cell tolerance can be achieved by tolerogenic DCs, which have the capacity of blocking undesired autoimmune responses in several experimental models, mainly by inducing T cell anergy, expansion of regulatory T cells and limiting B cell responses. Due to the lack of specific therapies to treat autoimmune disorders and the tolerogenic capacity of DCs shown in experimental autoimmune disease models, autologous tolDCs are a potential therapeutic strategy for fine-tuning the immune system and reestablishing tolerance in human autoimmune diseases. New advances in the role of DCs in systemic lupus erythematosus (SLE) pathogenesis and the identification of pathogenic self-Ags may favor the development of novel tolDC based therapies with a major clinical impact. In this review, we discuss recent data relative to the role of DCs in systemic autoimmune pathogenesis and their use as a therapy to restore tolerance.
Fil: Mackern Oberti, Juan Pablo. Pontificia Universidad Católica de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Llanos, Carolina. Pontificia Universidad Católica de Chile; Chile
Fil: Vega, Fabián. Pontificia Universidad Católica de Chile; Chile
Fil: Salazar-Onfray, Flavio. Universidad de Chile; Chile
Fil: Riedel, Claudia A.. Universidad Andrés Bello; Chile. Inserm; Francia
Fil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; Chile. Inserm; Francia
Fil: Kalergis, Alexis. Pontificia Universidad Católica de Chile; Chile. Inserm; Francia
Materia
DENDRITIC CELLS
IMMUNE TOLERANCE
IMMUNOTHERAPY
LUPUS
SYSTEMIC AUTOIMMUNITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/92586
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/92586
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseasesMackern Oberti, Juan PabloLlanos, CarolinaVega, FabiánSalazar Onfray, FlavioRiedel, Claudia A.Bueno, Mirian SusanaKalergis, AlexisDENDRITIC CELLSIMMUNE TOLERANCEIMMUNOTHERAPYLUPUSSYSTEMIC AUTOIMMUNITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory receptors expressed on the surface of DCs has been linked to increased susceptibility to develop autoimmune diseases underscoring their immunogenicity potential. It has been described that modulation of activating or inhibitory molecules expressed by DCs, such as CD86, TLRs, PDL-1 and FcγRs, can define the immunogenic phenotype. On the other hand, T cell tolerance can be achieved by tolerogenic DCs, which have the capacity of blocking undesired autoimmune responses in several experimental models, mainly by inducing T cell anergy, expansion of regulatory T cells and limiting B cell responses. Due to the lack of specific therapies to treat autoimmune disorders and the tolerogenic capacity of DCs shown in experimental autoimmune disease models, autologous tolDCs are a potential therapeutic strategy for fine-tuning the immune system and reestablishing tolerance in human autoimmune diseases. New advances in the role of DCs in systemic lupus erythematosus (SLE) pathogenesis and the identification of pathogenic self-Ags may favor the development of novel tolDC based therapies with a major clinical impact. In this review, we discuss recent data relative to the role of DCs in systemic autoimmune pathogenesis and their use as a therapy to restore tolerance.Fil: Mackern Oberti, Juan Pablo. Pontificia Universidad Católica de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Llanos, Carolina. Pontificia Universidad Católica de Chile; ChileFil: Vega, Fabián. Pontificia Universidad Católica de Chile; ChileFil: Salazar-Onfray, Flavio. Universidad de Chile; ChileFil: Riedel, Claudia A.. Universidad Andrés Bello; Chile. Inserm; FranciaFil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; Chile. Inserm; FranciaFil: Kalergis, Alexis. Pontificia Universidad Católica de Chile; Chile. Inserm; FranciaElsevier Science2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92586Mackern Oberti, Juan Pablo; Llanos, Carolina; Vega, Fabián; Salazar Onfray, Flavio; Riedel, Claudia A.; et al.; Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases; Elsevier Science; Autoimmunity Reviews; 14; 2; 2-2015; 127-1391568-9972CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.autrev.2014.10.010info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1568997214002225info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:53Zoai:ri.conicet.gov.ar:11336/92586instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:54.114CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
title Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
spellingShingle Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
Mackern Oberti, Juan Pablo
DENDRITIC CELLS
IMMUNE TOLERANCE
IMMUNOTHERAPY
LUPUS
SYSTEMIC AUTOIMMUNITY
title_short Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
title_full Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
title_fullStr Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
title_full_unstemmed Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
title_sort Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
dc.creator.none.fl_str_mv Mackern Oberti, Juan Pablo
Llanos, Carolina
Vega, Fabián
Salazar Onfray, Flavio
Riedel, Claudia A.
Bueno, Mirian Susana
Kalergis, Alexis
author Mackern Oberti, Juan Pablo
author_facet Mackern Oberti, Juan Pablo
Llanos, Carolina
Vega, Fabián
Salazar Onfray, Flavio
Riedel, Claudia A.
Bueno, Mirian Susana
Kalergis, Alexis
author_role author
author2 Llanos, Carolina
Vega, Fabián
Salazar Onfray, Flavio
Riedel, Claudia A.
Bueno, Mirian Susana
Kalergis, Alexis
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv DENDRITIC CELLS
IMMUNE TOLERANCE
IMMUNOTHERAPY
LUPUS
SYSTEMIC AUTOIMMUNITY
topic DENDRITIC CELLS
IMMUNE TOLERANCE
IMMUNOTHERAPY
LUPUS
SYSTEMIC AUTOIMMUNITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory receptors expressed on the surface of DCs has been linked to increased susceptibility to develop autoimmune diseases underscoring their immunogenicity potential. It has been described that modulation of activating or inhibitory molecules expressed by DCs, such as CD86, TLRs, PDL-1 and FcγRs, can define the immunogenic phenotype. On the other hand, T cell tolerance can be achieved by tolerogenic DCs, which have the capacity of blocking undesired autoimmune responses in several experimental models, mainly by inducing T cell anergy, expansion of regulatory T cells and limiting B cell responses. Due to the lack of specific therapies to treat autoimmune disorders and the tolerogenic capacity of DCs shown in experimental autoimmune disease models, autologous tolDCs are a potential therapeutic strategy for fine-tuning the immune system and reestablishing tolerance in human autoimmune diseases. New advances in the role of DCs in systemic lupus erythematosus (SLE) pathogenesis and the identification of pathogenic self-Ags may favor the development of novel tolDC based therapies with a major clinical impact. In this review, we discuss recent data relative to the role of DCs in systemic autoimmune pathogenesis and their use as a therapy to restore tolerance.
Fil: Mackern Oberti, Juan Pablo. Pontificia Universidad Católica de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Llanos, Carolina. Pontificia Universidad Católica de Chile; Chile
Fil: Vega, Fabián. Pontificia Universidad Católica de Chile; Chile
Fil: Salazar-Onfray, Flavio. Universidad de Chile; Chile
Fil: Riedel, Claudia A.. Universidad Andrés Bello; Chile. Inserm; Francia
Fil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; Chile. Inserm; Francia
Fil: Kalergis, Alexis. Pontificia Universidad Católica de Chile; Chile. Inserm; Francia
description Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory receptors expressed on the surface of DCs has been linked to increased susceptibility to develop autoimmune diseases underscoring their immunogenicity potential. It has been described that modulation of activating or inhibitory molecules expressed by DCs, such as CD86, TLRs, PDL-1 and FcγRs, can define the immunogenic phenotype. On the other hand, T cell tolerance can be achieved by tolerogenic DCs, which have the capacity of blocking undesired autoimmune responses in several experimental models, mainly by inducing T cell anergy, expansion of regulatory T cells and limiting B cell responses. Due to the lack of specific therapies to treat autoimmune disorders and the tolerogenic capacity of DCs shown in experimental autoimmune disease models, autologous tolDCs are a potential therapeutic strategy for fine-tuning the immune system and reestablishing tolerance in human autoimmune diseases. New advances in the role of DCs in systemic lupus erythematosus (SLE) pathogenesis and the identification of pathogenic self-Ags may favor the development of novel tolDC based therapies with a major clinical impact. In this review, we discuss recent data relative to the role of DCs in systemic autoimmune pathogenesis and their use as a therapy to restore tolerance.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/92586
Mackern Oberti, Juan Pablo; Llanos, Carolina; Vega, Fabián; Salazar Onfray, Flavio; Riedel, Claudia A.; et al.; Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases; Elsevier Science; Autoimmunity Reviews; 14; 2; 2-2015; 127-139
1568-9972
CONICET Digital
CONICET
url http://hdl.handle.net/11336/92586
identifier_str_mv Mackern Oberti, Juan Pablo; Llanos, Carolina; Vega, Fabián; Salazar Onfray, Flavio; Riedel, Claudia A.; et al.; Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases; Elsevier Science; Autoimmunity Reviews; 14; 2; 2-2015; 127-139
1568-9972
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.autrev.2014.10.010
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1568997214002225
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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