Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
- Autores
- Mora, Valentina P.; Quero, Francisco B.; Troncoso Bravo, Tays; Orellana, Claudia; Pereira, Patricia; Mackern Oberti, Juan Pablo; Funes, Samanta Celeste; Soto, Jorge A.; Bohmwald, Karen; Bueno, Mirian Susana; Kalergis, Alexis M.
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus´s autoimmune response.
Fil: Mora, Valentina P.. Pontificia Universidad Católica de Chile; Chile. Universidad Autónoma de Chile; Chile
Fil: Quero, Francisco B.. Pontificia Universidad Católica de Chile; Chile
Fil: Troncoso Bravo, Tays. Pontificia Universidad Católica de Chile; Chile
Fil: Orellana, Claudia. Pontificia Universidad Católica de Chile; Chile
Fil: Pereira, Patricia. Pontificia Universidad Católica de Chile; Chile
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Soto, Jorge A.. Universidad Andrés Bello; Chile
Fil: Bohmwald, Karen. Universidad Autónoma de Chile; Chile
Fil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile - Materia
-
BCG
Systemic lupus erythematosus
Autoimmunity
Immunozation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/266203
Ver los metadatos del registro completo
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Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone miceMora, Valentina P.Quero, Francisco B.Troncoso Bravo, TaysOrellana, ClaudiaPereira, PatriciaMackern Oberti, Juan PabloFunes, Samanta CelesteSoto, Jorge A.Bohmwald, KarenBueno, Mirian SusanaKalergis, Alexis M.BCGSystemic lupus erythematosusAutoimmunityImmunozationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus´s autoimmune response.Fil: Mora, Valentina P.. Pontificia Universidad Católica de Chile; Chile. Universidad Autónoma de Chile; ChileFil: Quero, Francisco B.. Pontificia Universidad Católica de Chile; ChileFil: Troncoso Bravo, Tays. Pontificia Universidad Católica de Chile; ChileFil: Orellana, Claudia. Pontificia Universidad Católica de Chile; ChileFil: Pereira, Patricia. Pontificia Universidad Católica de Chile; ChileFil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; ArgentinaFil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Soto, Jorge A.. Universidad Andrés Bello; ChileFil: Bohmwald, Karen. Universidad Autónoma de Chile; ChileFil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; ChileFil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; ChileTaylor & Francis Ltd2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266203Mora, Valentina P.; Quero, Francisco B.; Troncoso Bravo, Tays; Orellana, Claudia; Pereira, Patricia; et al.; Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice; Taylor & Francis Ltd; Autoimmunity; 57; 1; 7-2024; 1-150891-6934CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/08916934.2024.2380465info:eu-repo/semantics/altIdentifier/doi/10.1080/08916934.2024.2380465info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:07Zoai:ri.conicet.gov.ar:11336/266203instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:08.299CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice |
title |
Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice |
spellingShingle |
Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice Mora, Valentina P. BCG Systemic lupus erythematosus Autoimmunity Immunozation |
title_short |
Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice |
title_full |
Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice |
title_fullStr |
Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice |
title_full_unstemmed |
Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice |
title_sort |
Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice |
dc.creator.none.fl_str_mv |
Mora, Valentina P. Quero, Francisco B. Troncoso Bravo, Tays Orellana, Claudia Pereira, Patricia Mackern Oberti, Juan Pablo Funes, Samanta Celeste Soto, Jorge A. Bohmwald, Karen Bueno, Mirian Susana Kalergis, Alexis M. |
author |
Mora, Valentina P. |
author_facet |
Mora, Valentina P. Quero, Francisco B. Troncoso Bravo, Tays Orellana, Claudia Pereira, Patricia Mackern Oberti, Juan Pablo Funes, Samanta Celeste Soto, Jorge A. Bohmwald, Karen Bueno, Mirian Susana Kalergis, Alexis M. |
author_role |
author |
author2 |
Quero, Francisco B. Troncoso Bravo, Tays Orellana, Claudia Pereira, Patricia Mackern Oberti, Juan Pablo Funes, Samanta Celeste Soto, Jorge A. Bohmwald, Karen Bueno, Mirian Susana Kalergis, Alexis M. |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
BCG Systemic lupus erythematosus Autoimmunity Immunozation |
topic |
BCG Systemic lupus erythematosus Autoimmunity Immunozation |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus´s autoimmune response. Fil: Mora, Valentina P.. Pontificia Universidad Católica de Chile; Chile. Universidad Autónoma de Chile; Chile Fil: Quero, Francisco B.. Pontificia Universidad Católica de Chile; Chile Fil: Troncoso Bravo, Tays. Pontificia Universidad Católica de Chile; Chile Fil: Orellana, Claudia. Pontificia Universidad Católica de Chile; Chile Fil: Pereira, Patricia. Pontificia Universidad Católica de Chile; Chile Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Soto, Jorge A.. Universidad Andrés Bello; Chile Fil: Bohmwald, Karen. Universidad Autónoma de Chile; Chile Fil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; Chile Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile |
description |
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus´s autoimmune response. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/266203 Mora, Valentina P.; Quero, Francisco B.; Troncoso Bravo, Tays; Orellana, Claudia; Pereira, Patricia; et al.; Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice; Taylor & Francis Ltd; Autoimmunity; 57; 1; 7-2024; 1-15 0891-6934 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/266203 |
identifier_str_mv |
Mora, Valentina P.; Quero, Francisco B.; Troncoso Bravo, Tays; Orellana, Claudia; Pereira, Patricia; et al.; Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice; Taylor & Francis Ltd; Autoimmunity; 57; 1; 7-2024; 1-15 0891-6934 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/08916934.2024.2380465 info:eu-repo/semantics/altIdentifier/doi/10.1080/08916934.2024.2380465 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis Ltd |
publisher.none.fl_str_mv |
Taylor & Francis Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846082636978585600 |
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13.22299 |