Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice

Autores
Mora, Valentina P.; Quero, Francisco B.; Troncoso Bravo, Tays; Orellana, Claudia; Pereira, Patricia; Mackern Oberti, Juan Pablo; Funes, Samanta Celeste; Soto, Jorge A.; Bohmwald, Karen; Bueno, Mirian Susana; Kalergis, Alexis M.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus´s autoimmune response.
Fil: Mora, Valentina P.. Pontificia Universidad Católica de Chile; Chile. Universidad Autónoma de Chile; Chile
Fil: Quero, Francisco B.. Pontificia Universidad Católica de Chile; Chile
Fil: Troncoso Bravo, Tays. Pontificia Universidad Católica de Chile; Chile
Fil: Orellana, Claudia. Pontificia Universidad Católica de Chile; Chile
Fil: Pereira, Patricia. Pontificia Universidad Católica de Chile; Chile
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Soto, Jorge A.. Universidad Andrés Bello; Chile
Fil: Bohmwald, Karen. Universidad Autónoma de Chile; Chile
Fil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
Materia
BCG
Systemic lupus erythematosus
Autoimmunity
Immunozation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266203

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oai_identifier_str oai:ri.conicet.gov.ar:11336/266203
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone miceMora, Valentina P.Quero, Francisco B.Troncoso Bravo, TaysOrellana, ClaudiaPereira, PatriciaMackern Oberti, Juan PabloFunes, Samanta CelesteSoto, Jorge A.Bohmwald, KarenBueno, Mirian SusanaKalergis, Alexis M.BCGSystemic lupus erythematosusAutoimmunityImmunozationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus´s autoimmune response.Fil: Mora, Valentina P.. Pontificia Universidad Católica de Chile; Chile. Universidad Autónoma de Chile; ChileFil: Quero, Francisco B.. Pontificia Universidad Católica de Chile; ChileFil: Troncoso Bravo, Tays. Pontificia Universidad Católica de Chile; ChileFil: Orellana, Claudia. Pontificia Universidad Católica de Chile; ChileFil: Pereira, Patricia. Pontificia Universidad Católica de Chile; ChileFil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; ArgentinaFil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Soto, Jorge A.. Universidad Andrés Bello; ChileFil: Bohmwald, Karen. Universidad Autónoma de Chile; ChileFil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; ChileFil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; ChileTaylor & Francis Ltd2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266203Mora, Valentina P.; Quero, Francisco B.; Troncoso Bravo, Tays; Orellana, Claudia; Pereira, Patricia; et al.; Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice; Taylor & Francis Ltd; Autoimmunity; 57; 1; 7-2024; 1-150891-6934CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/08916934.2024.2380465info:eu-repo/semantics/altIdentifier/doi/10.1080/08916934.2024.2380465info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:07Zoai:ri.conicet.gov.ar:11336/266203instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:08.299CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
title Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
spellingShingle Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
Mora, Valentina P.
BCG
Systemic lupus erythematosus
Autoimmunity
Immunozation
title_short Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
title_full Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
title_fullStr Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
title_full_unstemmed Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
title_sort Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice
dc.creator.none.fl_str_mv Mora, Valentina P.
Quero, Francisco B.
Troncoso Bravo, Tays
Orellana, Claudia
Pereira, Patricia
Mackern Oberti, Juan Pablo
Funes, Samanta Celeste
Soto, Jorge A.
Bohmwald, Karen
Bueno, Mirian Susana
Kalergis, Alexis M.
author Mora, Valentina P.
author_facet Mora, Valentina P.
Quero, Francisco B.
Troncoso Bravo, Tays
Orellana, Claudia
Pereira, Patricia
Mackern Oberti, Juan Pablo
Funes, Samanta Celeste
Soto, Jorge A.
Bohmwald, Karen
Bueno, Mirian Susana
Kalergis, Alexis M.
author_role author
author2 Quero, Francisco B.
Troncoso Bravo, Tays
Orellana, Claudia
Pereira, Patricia
Mackern Oberti, Juan Pablo
Funes, Samanta Celeste
Soto, Jorge A.
Bohmwald, Karen
Bueno, Mirian Susana
Kalergis, Alexis M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BCG
Systemic lupus erythematosus
Autoimmunity
Immunozation
topic BCG
Systemic lupus erythematosus
Autoimmunity
Immunozation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus´s autoimmune response.
Fil: Mora, Valentina P.. Pontificia Universidad Católica de Chile; Chile. Universidad Autónoma de Chile; Chile
Fil: Quero, Francisco B.. Pontificia Universidad Católica de Chile; Chile
Fil: Troncoso Bravo, Tays. Pontificia Universidad Católica de Chile; Chile
Fil: Orellana, Claudia. Pontificia Universidad Católica de Chile; Chile
Fil: Pereira, Patricia. Pontificia Universidad Católica de Chile; Chile
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Soto, Jorge A.. Universidad Andrés Bello; Chile
Fil: Bohmwald, Karen. Universidad Autónoma de Chile; Chile
Fil: Bueno, Mirian Susana. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
description Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus´s autoimmune response.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266203
Mora, Valentina P.; Quero, Francisco B.; Troncoso Bravo, Tays; Orellana, Claudia; Pereira, Patricia; et al.; Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice; Taylor & Francis Ltd; Autoimmunity; 57; 1; 7-2024; 1-15
0891-6934
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266203
identifier_str_mv Mora, Valentina P.; Quero, Francisco B.; Troncoso Bravo, Tays; Orellana, Claudia; Pereira, Patricia; et al.; Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice; Taylor & Francis Ltd; Autoimmunity; 57; 1; 7-2024; 1-15
0891-6934
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/08916934.2024.2380465
info:eu-repo/semantics/altIdentifier/doi/10.1080/08916934.2024.2380465
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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