Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus

Autores
Mackern Oberti, Juan Pablo; Llanos, Carolina; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Systemic lupus erythematosus (SLE) is a heterogeneous disease in which excessive inflammation, autoantibodies and complement activation lead to multisystem tissue damage. The contribution of the individual genetic composition has been extensively studied, and several susceptibility genes related to immune pathways that participate in SLE pathogenesis have been identified. It has been proposed that SLE takes place when susceptibility factors interact with environmental stimuli leading to a deregulated immune response. Experimental evidence suggests that such events are related to the failure of T-cell and B-cell suppression mediated by defects in cell signalling, immune tolerance and apoptotic mechanism promoting autoimmunity. In addition, it has been reported that dendritic cells (DCs) from SLE patients, which are crucial in the modulation of peripheral tolerance to self-antigens, show an increased ratio of activating/inhibitory receptors on their surfaces. This phenotype and an augmented expression of co-stimulatory molecules is thought to be critical for disease pathogenesis. Accordingly, tolerogenic DCs can be a potential strategy for developing antigen-specific therapies to reduce detrimental inflammation without causing systemic immunosuppression. In this review article we discuss the most relevant data relative to the contribution of DCs to the triggering of SLE.
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica de Chile; Chile
Fil: Llanos, Carolina. Pontificia Universidad Católica de Chile; Chile
Fil: Riedel, Claudia A.. Universidad Andrés Bello; Chile
Fil: Bueno, Susan M.. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
Materia
DENDRITIC CELLS
IMMUNE TOLERANCE
IMMUNOTHERAPY
LUPUS
SYSTEMIC AUTOIMMUNITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210319
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus ErythematosusMackern Oberti, Juan PabloLlanos, CarolinaRiedel, Claudia A.Bueno, Susan M.Kalergis, Alexis M.DENDRITIC CELLSIMMUNE TOLERANCEIMMUNOTHERAPYLUPUSSYSTEMIC AUTOIMMUNITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Systemic lupus erythematosus (SLE) is a heterogeneous disease in which excessive inflammation, autoantibodies and complement activation lead to multisystem tissue damage. The contribution of the individual genetic composition has been extensively studied, and several susceptibility genes related to immune pathways that participate in SLE pathogenesis have been identified. It has been proposed that SLE takes place when susceptibility factors interact with environmental stimuli leading to a deregulated immune response. Experimental evidence suggests that such events are related to the failure of T-cell and B-cell suppression mediated by defects in cell signalling, immune tolerance and apoptotic mechanism promoting autoimmunity. In addition, it has been reported that dendritic cells (DCs) from SLE patients, which are crucial in the modulation of peripheral tolerance to self-antigens, show an increased ratio of activating/inhibitory receptors on their surfaces. This phenotype and an augmented expression of co-stimulatory molecules is thought to be critical for disease pathogenesis. Accordingly, tolerogenic DCs can be a potential strategy for developing antigen-specific therapies to reduce detrimental inflammation without causing systemic immunosuppression. In this review article we discuss the most relevant data relative to the contribution of DCs to the triggering of SLE.Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica de Chile; ChileFil: Llanos, Carolina. Pontificia Universidad Católica de Chile; ChileFil: Riedel, Claudia A.. Universidad Andrés Bello; ChileFil: Bueno, Susan M.. Pontificia Universidad Católica de Chile; ChileFil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; ChileWiley Blackwell Publishing, Inc2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210319Mackern Oberti, Juan Pablo; Llanos, Carolina; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M.; Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus; Wiley Blackwell Publishing, Inc; Immunology; 146; 4; 7-2015; 497-5070019-2805CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.onlinelibrary.wiley.com/journal.1365-2567.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1111/imm.12504info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:16Zoai:ri.conicet.gov.ar:11336/210319instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:16.455CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus
title Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus
spellingShingle Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus
Mackern Oberti, Juan Pablo
DENDRITIC CELLS
IMMUNE TOLERANCE
IMMUNOTHERAPY
LUPUS
SYSTEMIC AUTOIMMUNITY
title_short Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus
title_full Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus
title_fullStr Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus
title_full_unstemmed Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus
title_sort Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus
dc.creator.none.fl_str_mv Mackern Oberti, Juan Pablo
Llanos, Carolina
Riedel, Claudia A.
Bueno, Susan M.
Kalergis, Alexis M.
author Mackern Oberti, Juan Pablo
author_facet Mackern Oberti, Juan Pablo
Llanos, Carolina
Riedel, Claudia A.
Bueno, Susan M.
Kalergis, Alexis M.
author_role author
author2 Llanos, Carolina
Riedel, Claudia A.
Bueno, Susan M.
Kalergis, Alexis M.
author2_role author
author
author
author
dc.subject.none.fl_str_mv DENDRITIC CELLS
IMMUNE TOLERANCE
IMMUNOTHERAPY
LUPUS
SYSTEMIC AUTOIMMUNITY
topic DENDRITIC CELLS
IMMUNE TOLERANCE
IMMUNOTHERAPY
LUPUS
SYSTEMIC AUTOIMMUNITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Systemic lupus erythematosus (SLE) is a heterogeneous disease in which excessive inflammation, autoantibodies and complement activation lead to multisystem tissue damage. The contribution of the individual genetic composition has been extensively studied, and several susceptibility genes related to immune pathways that participate in SLE pathogenesis have been identified. It has been proposed that SLE takes place when susceptibility factors interact with environmental stimuli leading to a deregulated immune response. Experimental evidence suggests that such events are related to the failure of T-cell and B-cell suppression mediated by defects in cell signalling, immune tolerance and apoptotic mechanism promoting autoimmunity. In addition, it has been reported that dendritic cells (DCs) from SLE patients, which are crucial in the modulation of peripheral tolerance to self-antigens, show an increased ratio of activating/inhibitory receptors on their surfaces. This phenotype and an augmented expression of co-stimulatory molecules is thought to be critical for disease pathogenesis. Accordingly, tolerogenic DCs can be a potential strategy for developing antigen-specific therapies to reduce detrimental inflammation without causing systemic immunosuppression. In this review article we discuss the most relevant data relative to the contribution of DCs to the triggering of SLE.
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica de Chile; Chile
Fil: Llanos, Carolina. Pontificia Universidad Católica de Chile; Chile
Fil: Riedel, Claudia A.. Universidad Andrés Bello; Chile
Fil: Bueno, Susan M.. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
description Systemic lupus erythematosus (SLE) is a heterogeneous disease in which excessive inflammation, autoantibodies and complement activation lead to multisystem tissue damage. The contribution of the individual genetic composition has been extensively studied, and several susceptibility genes related to immune pathways that participate in SLE pathogenesis have been identified. It has been proposed that SLE takes place when susceptibility factors interact with environmental stimuli leading to a deregulated immune response. Experimental evidence suggests that such events are related to the failure of T-cell and B-cell suppression mediated by defects in cell signalling, immune tolerance and apoptotic mechanism promoting autoimmunity. In addition, it has been reported that dendritic cells (DCs) from SLE patients, which are crucial in the modulation of peripheral tolerance to self-antigens, show an increased ratio of activating/inhibitory receptors on their surfaces. This phenotype and an augmented expression of co-stimulatory molecules is thought to be critical for disease pathogenesis. Accordingly, tolerogenic DCs can be a potential strategy for developing antigen-specific therapies to reduce detrimental inflammation without causing systemic immunosuppression. In this review article we discuss the most relevant data relative to the contribution of DCs to the triggering of SLE.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210319
Mackern Oberti, Juan Pablo; Llanos, Carolina; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M.; Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus; Wiley Blackwell Publishing, Inc; Immunology; 146; 4; 7-2015; 497-507
0019-2805
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210319
identifier_str_mv Mackern Oberti, Juan Pablo; Llanos, Carolina; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M.; Contribution of Dendritic cells to the autoimmune pathology of Systemic Lupus Erythematosus; Wiley Blackwell Publishing, Inc; Immunology; 146; 4; 7-2015; 497-507
0019-2805
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.onlinelibrary.wiley.com/journal.1365-2567.html
info:eu-repo/semantics/altIdentifier/doi/10.1111/imm.12504
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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