Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus

Autores
Mackern Oberti, Juan Pablo; Obreque, J.; Méndez, G. P.; Llanos, Carolina; Kalergis, Alexis
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Systemic lupus erythematosus is characterized by the presence of circulating anti-nuclear antibodies (ANA) and systemic damage that includes nephritis, haematological manifestations and pulmonary compromise, among others. Although major progress has been made in elucidating the molecular mechanisms responsible for autoimmunity, current therapies for lupus have not improved considerably. Because the exposure of carbon monoxide (CO) has been shown to display beneficial immunoregulatory properties in different immune-mediated diseases, we investigated whether CO therapy improves lupus-related kidney injury in lupus mice. MRL-Faslpr lupus mice were exposed to CO and disease progression was evaluated. ANA, leucocyte-infiltrating populations in spleen, kidney and lung and kidney lesions, were measured. CO therapy significantly decreased the frequency of activated B220+ CD4- CD8- T cells in kidneys and lungs, as well as serum levels of ANA. Furthermore, we observed that CO therapy reduced kidney injury by decreasing proliferative glomerular damage and immune complexes deposition, decreased proinflammatory cytokine production and finally delayed the impairment of kidney function. CO exposure ameliorates kidney and lung leucocyte infiltration and delays kidney disease in MRL-Faslpr lupus mice. Our data support the notion that CO could be explored as a potential new therapy for lupus nephritis.
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica de Chile; Chile
Fil: Obreque, J.. Pontificia Universidad Católica de Chile; Chile
Fil: Méndez, G. P.. Pontificia Universidad Católica de Chile; Chile
Fil: Llanos, Carolina. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis. Pontificia Universidad Católica de Chile; Chile
Materia
Carbon monoxide
immunotheraoy
autoimmunity
lupus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210329

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosusMackern Oberti, Juan PabloObreque, J.Méndez, G. P.Llanos, CarolinaKalergis, AlexisCarbon monoxideimmunotheraoyautoimmunitylupushttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Systemic lupus erythematosus is characterized by the presence of circulating anti-nuclear antibodies (ANA) and systemic damage that includes nephritis, haematological manifestations and pulmonary compromise, among others. Although major progress has been made in elucidating the molecular mechanisms responsible for autoimmunity, current therapies for lupus have not improved considerably. Because the exposure of carbon monoxide (CO) has been shown to display beneficial immunoregulatory properties in different immune-mediated diseases, we investigated whether CO therapy improves lupus-related kidney injury in lupus mice. MRL-Faslpr lupus mice were exposed to CO and disease progression was evaluated. ANA, leucocyte-infiltrating populations in spleen, kidney and lung and kidney lesions, were measured. CO therapy significantly decreased the frequency of activated B220+ CD4- CD8- T cells in kidneys and lungs, as well as serum levels of ANA. Furthermore, we observed that CO therapy reduced kidney injury by decreasing proliferative glomerular damage and immune complexes deposition, decreased proinflammatory cytokine production and finally delayed the impairment of kidney function. CO exposure ameliorates kidney and lung leucocyte infiltration and delays kidney disease in MRL-Faslpr lupus mice. Our data support the notion that CO could be explored as a potential new therapy for lupus nephritis.Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica de Chile; ChileFil: Obreque, J.. Pontificia Universidad Católica de Chile; ChileFil: Méndez, G. P.. Pontificia Universidad Católica de Chile; ChileFil: Llanos, Carolina. Pontificia Universidad Católica de Chile; ChileFil: Kalergis, Alexis. Pontificia Universidad Católica de Chile; ChileOxford University Press2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210329Mackern Oberti, Juan Pablo; Obreque, J.; Méndez, G. P.; Llanos, Carolina; Kalergis, Alexis; Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus; Oxford University Press; Clinical and Experimental Immunology; 7-2015; 1-130009-9104CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/cei.12657info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:49Zoai:ri.conicet.gov.ar:11336/210329instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:49.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus
title Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus
spellingShingle Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus
Mackern Oberti, Juan Pablo
Carbon monoxide
immunotheraoy
autoimmunity
lupus
title_short Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus
title_full Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus
title_fullStr Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus
title_full_unstemmed Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus
title_sort Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus
dc.creator.none.fl_str_mv Mackern Oberti, Juan Pablo
Obreque, J.
Méndez, G. P.
Llanos, Carolina
Kalergis, Alexis
author Mackern Oberti, Juan Pablo
author_facet Mackern Oberti, Juan Pablo
Obreque, J.
Méndez, G. P.
Llanos, Carolina
Kalergis, Alexis
author_role author
author2 Obreque, J.
Méndez, G. P.
Llanos, Carolina
Kalergis, Alexis
author2_role author
author
author
author
dc.subject.none.fl_str_mv Carbon monoxide
immunotheraoy
autoimmunity
lupus
topic Carbon monoxide
immunotheraoy
autoimmunity
lupus
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Systemic lupus erythematosus is characterized by the presence of circulating anti-nuclear antibodies (ANA) and systemic damage that includes nephritis, haematological manifestations and pulmonary compromise, among others. Although major progress has been made in elucidating the molecular mechanisms responsible for autoimmunity, current therapies for lupus have not improved considerably. Because the exposure of carbon monoxide (CO) has been shown to display beneficial immunoregulatory properties in different immune-mediated diseases, we investigated whether CO therapy improves lupus-related kidney injury in lupus mice. MRL-Faslpr lupus mice were exposed to CO and disease progression was evaluated. ANA, leucocyte-infiltrating populations in spleen, kidney and lung and kidney lesions, were measured. CO therapy significantly decreased the frequency of activated B220+ CD4- CD8- T cells in kidneys and lungs, as well as serum levels of ANA. Furthermore, we observed that CO therapy reduced kidney injury by decreasing proliferative glomerular damage and immune complexes deposition, decreased proinflammatory cytokine production and finally delayed the impairment of kidney function. CO exposure ameliorates kidney and lung leucocyte infiltration and delays kidney disease in MRL-Faslpr lupus mice. Our data support the notion that CO could be explored as a potential new therapy for lupus nephritis.
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Pontificia Universidad Católica de Chile; Chile
Fil: Obreque, J.. Pontificia Universidad Católica de Chile; Chile
Fil: Méndez, G. P.. Pontificia Universidad Católica de Chile; Chile
Fil: Llanos, Carolina. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis. Pontificia Universidad Católica de Chile; Chile
description Systemic lupus erythematosus is characterized by the presence of circulating anti-nuclear antibodies (ANA) and systemic damage that includes nephritis, haematological manifestations and pulmonary compromise, among others. Although major progress has been made in elucidating the molecular mechanisms responsible for autoimmunity, current therapies for lupus have not improved considerably. Because the exposure of carbon monoxide (CO) has been shown to display beneficial immunoregulatory properties in different immune-mediated diseases, we investigated whether CO therapy improves lupus-related kidney injury in lupus mice. MRL-Faslpr lupus mice were exposed to CO and disease progression was evaluated. ANA, leucocyte-infiltrating populations in spleen, kidney and lung and kidney lesions, were measured. CO therapy significantly decreased the frequency of activated B220+ CD4- CD8- T cells in kidneys and lungs, as well as serum levels of ANA. Furthermore, we observed that CO therapy reduced kidney injury by decreasing proliferative glomerular damage and immune complexes deposition, decreased proinflammatory cytokine production and finally delayed the impairment of kidney function. CO exposure ameliorates kidney and lung leucocyte infiltration and delays kidney disease in MRL-Faslpr lupus mice. Our data support the notion that CO could be explored as a potential new therapy for lupus nephritis.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210329
Mackern Oberti, Juan Pablo; Obreque, J.; Méndez, G. P.; Llanos, Carolina; Kalergis, Alexis; Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus; Oxford University Press; Clinical and Experimental Immunology; 7-2015; 1-13
0009-9104
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210329
identifier_str_mv Mackern Oberti, Juan Pablo; Obreque, J.; Méndez, G. P.; Llanos, Carolina; Kalergis, Alexis; Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus; Oxford University Press; Clinical and Experimental Immunology; 7-2015; 1-13
0009-9104
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/cei.12657
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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