Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review

Autores
Ceribelli, Angela; Isailovic, Natasa; De Santis, Maria; Generali, Elena; Gorlino, Carolina Virginia; Palermo, Bianca; Selmi, Carlo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The identification of serum autoantibodies is central in the diagnosis of systemic autoimmune rheumatic disease (SARD), and an increasing number of specificities have been detected in the past years. This allows an early diagnosis in the active phases of diseases, with the identification of specific disease subsets that may ultimately improve the disease outcomes. Thanks to the use of old and new laboratory techniques that are becoming increasingly available worldwide, the number of rheumatic patients with a specific autoantibody is increasing and this is improving also our knowledge of disease trigger mechanisms. The paradigmatic example is the plethora of serum autoantibodies described in polymyositis and dermatomyositis, coined myositis-specific antibodies (MSA) which include antibodies directed against tRNA synthetases, anti-SRP, anti-Mi-2, and anti-TIF-1γ and can discriminate disease subtypes, particularly when associated with the risk of cancer. As a further example, anti-HMGCR antibodies have been reported in several studies in association with necrotizing autoimmune myositis that may follow statin use. To clarify the current knowledge on these rare specificities, we performed a systematic literature review. We focused on the main features associated to specific autoantibodies that are rarely identified in rheumatic disease, to increase the awareness and scientific knowledge on these autoantibodies in different ethnic groups worldwide.
Fil: Ceribelli, Angela. Humanitas Research Hospital; Italia. Università degli Studi di Milano; Italia
Fil: Isailovic, Natasa. Humanitas Research Hospital; Italia
Fil: De Santis, Maria. Humanitas Research Hospital; Italia
Fil: Generali, Elena. Humanitas Research Hospital; Italia
Fil: Gorlino, Carolina Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Humanitas Research Hospital; Italia
Fil: Palermo, Bianca. Humanitas Research Hospital; Italia
Fil: Selmi, Carlo. Università degli Studi di Milano; Italia. Humanitas Research Hospital; Italia
Materia
IMMUNE TOLERANCE
AUTOIMMUNITY
SYSTEMIC SCLEROSIS
SYSTEMIC LUPUS ERITHEMATOSUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/89003
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature reviewCeribelli, AngelaIsailovic, NatasaDe Santis, MariaGenerali, ElenaGorlino, Carolina VirginiaPalermo, BiancaSelmi, CarloIMMUNE TOLERANCEAUTOIMMUNITYSYSTEMIC SCLEROSISSYSTEMIC LUPUS ERITHEMATOSUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The identification of serum autoantibodies is central in the diagnosis of systemic autoimmune rheumatic disease (SARD), and an increasing number of specificities have been detected in the past years. This allows an early diagnosis in the active phases of diseases, with the identification of specific disease subsets that may ultimately improve the disease outcomes. Thanks to the use of old and new laboratory techniques that are becoming increasingly available worldwide, the number of rheumatic patients with a specific autoantibody is increasing and this is improving also our knowledge of disease trigger mechanisms. The paradigmatic example is the plethora of serum autoantibodies described in polymyositis and dermatomyositis, coined myositis-specific antibodies (MSA) which include antibodies directed against tRNA synthetases, anti-SRP, anti-Mi-2, and anti-TIF-1γ and can discriminate disease subtypes, particularly when associated with the risk of cancer. As a further example, anti-HMGCR antibodies have been reported in several studies in association with necrotizing autoimmune myositis that may follow statin use. To clarify the current knowledge on these rare specificities, we performed a systematic literature review. We focused on the main features associated to specific autoantibodies that are rarely identified in rheumatic disease, to increase the awareness and scientific knowledge on these autoantibodies in different ethnic groups worldwide.Fil: Ceribelli, Angela. Humanitas Research Hospital; Italia. Università degli Studi di Milano; ItaliaFil: Isailovic, Natasa. Humanitas Research Hospital; ItaliaFil: De Santis, Maria. Humanitas Research Hospital; ItaliaFil: Generali, Elena. Humanitas Research Hospital; ItaliaFil: Gorlino, Carolina Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Humanitas Research Hospital; ItaliaFil: Palermo, Bianca. Humanitas Research Hospital; ItaliaFil: Selmi, Carlo. Università degli Studi di Milano; Italia. Humanitas Research Hospital; ItaliaAME Publishing Company2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89003Ceribelli, Angela; Isailovic, Natasa; De Santis, Maria; Generali, Elena; Gorlino, Carolina Virginia; et al.; Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review; AME Publishing Company; Journal of Laboratory and Precision Medicine; 3; 10-2018; 89-892519-9005CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.21037/jlpm.2018.09.13info:eu-repo/semantics/altIdentifier/url/http://jlpm.amegroups.com/article/view/4579/5636info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:54:52Zoai:ri.conicet.gov.ar:11336/89003instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:54:53.032CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
title Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
spellingShingle Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
Ceribelli, Angela
IMMUNE TOLERANCE
AUTOIMMUNITY
SYSTEMIC SCLEROSIS
SYSTEMIC LUPUS ERITHEMATOSUS
title_short Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
title_full Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
title_fullStr Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
title_full_unstemmed Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
title_sort Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review
dc.creator.none.fl_str_mv Ceribelli, Angela
Isailovic, Natasa
De Santis, Maria
Generali, Elena
Gorlino, Carolina Virginia
Palermo, Bianca
Selmi, Carlo
author Ceribelli, Angela
author_facet Ceribelli, Angela
Isailovic, Natasa
De Santis, Maria
Generali, Elena
Gorlino, Carolina Virginia
Palermo, Bianca
Selmi, Carlo
author_role author
author2 Isailovic, Natasa
De Santis, Maria
Generali, Elena
Gorlino, Carolina Virginia
Palermo, Bianca
Selmi, Carlo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv IMMUNE TOLERANCE
AUTOIMMUNITY
SYSTEMIC SCLEROSIS
SYSTEMIC LUPUS ERITHEMATOSUS
topic IMMUNE TOLERANCE
AUTOIMMUNITY
SYSTEMIC SCLEROSIS
SYSTEMIC LUPUS ERITHEMATOSUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The identification of serum autoantibodies is central in the diagnosis of systemic autoimmune rheumatic disease (SARD), and an increasing number of specificities have been detected in the past years. This allows an early diagnosis in the active phases of diseases, with the identification of specific disease subsets that may ultimately improve the disease outcomes. Thanks to the use of old and new laboratory techniques that are becoming increasingly available worldwide, the number of rheumatic patients with a specific autoantibody is increasing and this is improving also our knowledge of disease trigger mechanisms. The paradigmatic example is the plethora of serum autoantibodies described in polymyositis and dermatomyositis, coined myositis-specific antibodies (MSA) which include antibodies directed against tRNA synthetases, anti-SRP, anti-Mi-2, and anti-TIF-1γ and can discriminate disease subtypes, particularly when associated with the risk of cancer. As a further example, anti-HMGCR antibodies have been reported in several studies in association with necrotizing autoimmune myositis that may follow statin use. To clarify the current knowledge on these rare specificities, we performed a systematic literature review. We focused on the main features associated to specific autoantibodies that are rarely identified in rheumatic disease, to increase the awareness and scientific knowledge on these autoantibodies in different ethnic groups worldwide.
Fil: Ceribelli, Angela. Humanitas Research Hospital; Italia. Università degli Studi di Milano; Italia
Fil: Isailovic, Natasa. Humanitas Research Hospital; Italia
Fil: De Santis, Maria. Humanitas Research Hospital; Italia
Fil: Generali, Elena. Humanitas Research Hospital; Italia
Fil: Gorlino, Carolina Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Humanitas Research Hospital; Italia
Fil: Palermo, Bianca. Humanitas Research Hospital; Italia
Fil: Selmi, Carlo. Università degli Studi di Milano; Italia. Humanitas Research Hospital; Italia
description The identification of serum autoantibodies is central in the diagnosis of systemic autoimmune rheumatic disease (SARD), and an increasing number of specificities have been detected in the past years. This allows an early diagnosis in the active phases of diseases, with the identification of specific disease subsets that may ultimately improve the disease outcomes. Thanks to the use of old and new laboratory techniques that are becoming increasingly available worldwide, the number of rheumatic patients with a specific autoantibody is increasing and this is improving also our knowledge of disease trigger mechanisms. The paradigmatic example is the plethora of serum autoantibodies described in polymyositis and dermatomyositis, coined myositis-specific antibodies (MSA) which include antibodies directed against tRNA synthetases, anti-SRP, anti-Mi-2, and anti-TIF-1γ and can discriminate disease subtypes, particularly when associated with the risk of cancer. As a further example, anti-HMGCR antibodies have been reported in several studies in association with necrotizing autoimmune myositis that may follow statin use. To clarify the current knowledge on these rare specificities, we performed a systematic literature review. We focused on the main features associated to specific autoantibodies that are rarely identified in rheumatic disease, to increase the awareness and scientific knowledge on these autoantibodies in different ethnic groups worldwide.
publishDate 2018
dc.date.none.fl_str_mv 2018-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/89003
Ceribelli, Angela; Isailovic, Natasa; De Santis, Maria; Generali, Elena; Gorlino, Carolina Virginia; et al.; Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review; AME Publishing Company; Journal of Laboratory and Precision Medicine; 3; 10-2018; 89-89
2519-9005
CONICET Digital
CONICET
url http://hdl.handle.net/11336/89003
identifier_str_mv Ceribelli, Angela; Isailovic, Natasa; De Santis, Maria; Generali, Elena; Gorlino, Carolina Virginia; et al.; Clinical significance of rare serum autoantibodies in rheumatic diseases: a systematic literature review; AME Publishing Company; Journal of Laboratory and Precision Medicine; 3; 10-2018; 89-89
2519-9005
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.21037/jlpm.2018.09.13
info:eu-repo/semantics/altIdentifier/url/http://jlpm.amegroups.com/article/view/4579/5636
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AME Publishing Company
publisher.none.fl_str_mv AME Publishing Company
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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