In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone

Autores
Turino, Ludmila Noelia; Mariano, Rodolfo Nicolás; Boimvaser, Sonia; Luna, Julio Alberto
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In situ-formed microspheres are an alternative to expensive and complex manufactured preformed systems for the controlled release of drugs. The aim of this study was to evaluate the potential of stable O/W emulsions to entrap progesterone after in vitro precipitation of poly(d,l-lactide-co-glycolide) (PLGA) microparticles. This was achieved by a solvent selection based on their miscibility and capability to solubilize the drug and PLGA. Stability assays, size distribution studies, and progesterone encapsulation efficiency evaluation were carried out for the candidate formulations. After selection of the most suitable formulations, in vitro-controlled release test of progesterone were done. Results demonstrate that emulsions based on triacetin and polyvinyl alcohol (PVA) aqueous solutions were useful solvent systems to obtain microspheres capable to deliver the hormone in a controlled release manner. In addition, for the first time, for these authors, PVA was successfully implemented into a continuous phase to increase the stability of in situ-formed O/W formulations.
Fil: Turino, Ludmila Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Fil: Mariano, Rodolfo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Fil: Boimvaser, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Materia
In Situ Forming Microspheres
Emulsion Stability
Progesterone
Plga
Pva
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9247
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesteroneTurino, Ludmila NoeliaMariano, Rodolfo NicolásBoimvaser, SoniaLuna, Julio AlbertoIn Situ Forming MicrospheresEmulsion StabilityProgesteronePlgaPvahttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2https://purl.org/becyt/ford/4.2https://purl.org/becyt/ford/4In situ-formed microspheres are an alternative to expensive and complex manufactured preformed systems for the controlled release of drugs. The aim of this study was to evaluate the potential of stable O/W emulsions to entrap progesterone after in vitro precipitation of poly(d,l-lactide-co-glycolide) (PLGA) microparticles. This was achieved by a solvent selection based on their miscibility and capability to solubilize the drug and PLGA. Stability assays, size distribution studies, and progesterone encapsulation efficiency evaluation were carried out for the candidate formulations. After selection of the most suitable formulations, in vitro-controlled release test of progesterone were done. Results demonstrate that emulsions based on triacetin and polyvinyl alcohol (PVA) aqueous solutions were useful solvent systems to obtain microspheres capable to deliver the hormone in a controlled release manner. In addition, for the first time, for these authors, PVA was successfully implemented into a continuous phase to increase the stability of in situ-formed O/W formulations.Fil: Turino, Ludmila Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Mariano, Rodolfo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Boimvaser, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaSpringer2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9247Turino, Ludmila Noelia; Mariano, Rodolfo Nicolás; Boimvaser, Sonia; Luna, Julio Alberto; In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone; Springer; Journal of Pharmaceutical Innovation From R&D to Market; 9; 2; 5-2014; 132-1401872-5120enginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s12247-014-9180-7info:eu-repo/semantics/altIdentifier/doi/10.1007/s12247-014-9180-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:08:48Zoai:ri.conicet.gov.ar:11336/9247instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:08:49.239CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone
title In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone
spellingShingle In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone
Turino, Ludmila Noelia
In Situ Forming Microspheres
Emulsion Stability
Progesterone
Plga
Pva
title_short In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone
title_full In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone
title_fullStr In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone
title_full_unstemmed In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone
title_sort In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone
dc.creator.none.fl_str_mv Turino, Ludmila Noelia
Mariano, Rodolfo Nicolás
Boimvaser, Sonia
Luna, Julio Alberto
author Turino, Ludmila Noelia
author_facet Turino, Ludmila Noelia
Mariano, Rodolfo Nicolás
Boimvaser, Sonia
Luna, Julio Alberto
author_role author
author2 Mariano, Rodolfo Nicolás
Boimvaser, Sonia
Luna, Julio Alberto
author2_role author
author
author
dc.subject.none.fl_str_mv In Situ Forming Microspheres
Emulsion Stability
Progesterone
Plga
Pva
topic In Situ Forming Microspheres
Emulsion Stability
Progesterone
Plga
Pva
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/4.2
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv In situ-formed microspheres are an alternative to expensive and complex manufactured preformed systems for the controlled release of drugs. The aim of this study was to evaluate the potential of stable O/W emulsions to entrap progesterone after in vitro precipitation of poly(d,l-lactide-co-glycolide) (PLGA) microparticles. This was achieved by a solvent selection based on their miscibility and capability to solubilize the drug and PLGA. Stability assays, size distribution studies, and progesterone encapsulation efficiency evaluation were carried out for the candidate formulations. After selection of the most suitable formulations, in vitro-controlled release test of progesterone were done. Results demonstrate that emulsions based on triacetin and polyvinyl alcohol (PVA) aqueous solutions were useful solvent systems to obtain microspheres capable to deliver the hormone in a controlled release manner. In addition, for the first time, for these authors, PVA was successfully implemented into a continuous phase to increase the stability of in situ-formed O/W formulations.
Fil: Turino, Ludmila Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Fil: Mariano, Rodolfo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Fil: Boimvaser, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina
description In situ-formed microspheres are an alternative to expensive and complex manufactured preformed systems for the controlled release of drugs. The aim of this study was to evaluate the potential of stable O/W emulsions to entrap progesterone after in vitro precipitation of poly(d,l-lactide-co-glycolide) (PLGA) microparticles. This was achieved by a solvent selection based on their miscibility and capability to solubilize the drug and PLGA. Stability assays, size distribution studies, and progesterone encapsulation efficiency evaluation were carried out for the candidate formulations. After selection of the most suitable formulations, in vitro-controlled release test of progesterone were done. Results demonstrate that emulsions based on triacetin and polyvinyl alcohol (PVA) aqueous solutions were useful solvent systems to obtain microspheres capable to deliver the hormone in a controlled release manner. In addition, for the first time, for these authors, PVA was successfully implemented into a continuous phase to increase the stability of in situ-formed O/W formulations.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9247
Turino, Ludmila Noelia; Mariano, Rodolfo Nicolás; Boimvaser, Sonia; Luna, Julio Alberto; In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone; Springer; Journal of Pharmaceutical Innovation From R&D to Market; 9; 2; 5-2014; 132-140
1872-5120
url http://hdl.handle.net/11336/9247
identifier_str_mv Turino, Ludmila Noelia; Mariano, Rodolfo Nicolás; Boimvaser, Sonia; Luna, Julio Alberto; In situ formed microparticles of PLGA from O/W emulsions stabilized with PVA: Encapsulation and controlled release of progesterone; Springer; Journal of Pharmaceutical Innovation From R&D to Market; 9; 2; 5-2014; 132-140
1872-5120
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s12247-014-9180-7
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12247-014-9180-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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