In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems

Autores
Boimvaser, Sonia; Mariano, Rodolfo Nicolás; Turino, Ludmila Noelia; Vega, Jorge Ruben
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work investigates the degradation of PLGA implants in an aqueous medium maintained at physiological pH ≈ 7.4. Two limiting systems are also investigated, which involve the degradation of PLGA microspheres in two different media characterized by: (i) a non-regulated pH, for emulating the autocatalyzed degradation in the implant core; and (ii) a regulated physiological pH, for emulating the uncatalyzed degradation at the implant surface. The degradation experiments were carried out along 40?50 days, and samples withdrawn during this period were characterized by gravimetry, electronic microscopy, and size exclusion chromatography. Experimental results suggest that PLGA implants are degraded according to a time-variant spatial pattern, which depends on the pH of the surrounding medium. Initially, the implants suffered a typically bulk erosion process, governed by the acidification of the implant core; and after breakage of the implant wall, the regulated physiological pH induces a surface erosion process. The two auxiliary microsphere-based experiments were useful to elucidate the degradation phenomena occurring in the PLGA implants. The evolution of the mass loss and the weight-average molecular weight along the degradation can be successfully predicted by simple mathematical models based on first-order kinetics.
Fil: Boimvaser, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Mariano, Rodolfo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Turino, Ludmila Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Vega, Jorge Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
Bulk/Surface Erosion
Implant
Microspheres
Non-Homogeneous Degradation
Physiological Condition
Plga
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23816
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23816
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systemsBoimvaser, SoniaMariano, Rodolfo NicolásTurino, Ludmila NoeliaVega, Jorge RubenBulk/Surface ErosionImplantMicrospheresNon-Homogeneous DegradationPhysiological ConditionPlgahttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2This work investigates the degradation of PLGA implants in an aqueous medium maintained at physiological pH ≈ 7.4. Two limiting systems are also investigated, which involve the degradation of PLGA microspheres in two different media characterized by: (i) a non-regulated pH, for emulating the autocatalyzed degradation in the implant core; and (ii) a regulated physiological pH, for emulating the uncatalyzed degradation at the implant surface. The degradation experiments were carried out along 40?50 days, and samples withdrawn during this period were characterized by gravimetry, electronic microscopy, and size exclusion chromatography. Experimental results suggest that PLGA implants are degraded according to a time-variant spatial pattern, which depends on the pH of the surrounding medium. Initially, the implants suffered a typically bulk erosion process, governed by the acidification of the implant core; and after breakage of the implant wall, the regulated physiological pH induces a surface erosion process. The two auxiliary microsphere-based experiments were useful to elucidate the degradation phenomena occurring in the PLGA implants. The evolution of the mass loss and the weight-average molecular weight along the degradation can be successfully predicted by simple mathematical models based on first-order kinetics.Fil: Boimvaser, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Mariano, Rodolfo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Turino, Ludmila Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Vega, Jorge Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaSpringer2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23816Boimvaser, Sonia; Mariano, Rodolfo Nicolás; Turino, Ludmila Noelia; Vega, Jorge Ruben; In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems; Springer; Polymer Bulletin; 73; 1; 1-2016; 209-2270170-0839CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00289-015-1481-6info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00289-015-1481-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:46Zoai:ri.conicet.gov.ar:11336/23816instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:46.522CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems
title In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems
spellingShingle In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems
Boimvaser, Sonia
Bulk/Surface Erosion
Implant
Microspheres
Non-Homogeneous Degradation
Physiological Condition
Plga
title_short In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems
title_full In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems
title_fullStr In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems
title_full_unstemmed In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems
title_sort In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems
dc.creator.none.fl_str_mv Boimvaser, Sonia
Mariano, Rodolfo Nicolás
Turino, Ludmila Noelia
Vega, Jorge Ruben
author Boimvaser, Sonia
author_facet Boimvaser, Sonia
Mariano, Rodolfo Nicolás
Turino, Ludmila Noelia
Vega, Jorge Ruben
author_role author
author2 Mariano, Rodolfo Nicolás
Turino, Ludmila Noelia
Vega, Jorge Ruben
author2_role author
author
author
dc.subject.none.fl_str_mv Bulk/Surface Erosion
Implant
Microspheres
Non-Homogeneous Degradation
Physiological Condition
Plga
topic Bulk/Surface Erosion
Implant
Microspheres
Non-Homogeneous Degradation
Physiological Condition
Plga
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv This work investigates the degradation of PLGA implants in an aqueous medium maintained at physiological pH ≈ 7.4. Two limiting systems are also investigated, which involve the degradation of PLGA microspheres in two different media characterized by: (i) a non-regulated pH, for emulating the autocatalyzed degradation in the implant core; and (ii) a regulated physiological pH, for emulating the uncatalyzed degradation at the implant surface. The degradation experiments were carried out along 40?50 days, and samples withdrawn during this period were characterized by gravimetry, electronic microscopy, and size exclusion chromatography. Experimental results suggest that PLGA implants are degraded according to a time-variant spatial pattern, which depends on the pH of the surrounding medium. Initially, the implants suffered a typically bulk erosion process, governed by the acidification of the implant core; and after breakage of the implant wall, the regulated physiological pH induces a surface erosion process. The two auxiliary microsphere-based experiments were useful to elucidate the degradation phenomena occurring in the PLGA implants. The evolution of the mass loss and the weight-average molecular weight along the degradation can be successfully predicted by simple mathematical models based on first-order kinetics.
Fil: Boimvaser, Sonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Mariano, Rodolfo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Turino, Ludmila Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Vega, Jorge Ruben. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description This work investigates the degradation of PLGA implants in an aqueous medium maintained at physiological pH ≈ 7.4. Two limiting systems are also investigated, which involve the degradation of PLGA microspheres in two different media characterized by: (i) a non-regulated pH, for emulating the autocatalyzed degradation in the implant core; and (ii) a regulated physiological pH, for emulating the uncatalyzed degradation at the implant surface. The degradation experiments were carried out along 40?50 days, and samples withdrawn during this period were characterized by gravimetry, electronic microscopy, and size exclusion chromatography. Experimental results suggest that PLGA implants are degraded according to a time-variant spatial pattern, which depends on the pH of the surrounding medium. Initially, the implants suffered a typically bulk erosion process, governed by the acidification of the implant core; and after breakage of the implant wall, the regulated physiological pH induces a surface erosion process. The two auxiliary microsphere-based experiments were useful to elucidate the degradation phenomena occurring in the PLGA implants. The evolution of the mass loss and the weight-average molecular weight along the degradation can be successfully predicted by simple mathematical models based on first-order kinetics.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23816
Boimvaser, Sonia; Mariano, Rodolfo Nicolás; Turino, Ludmila Noelia; Vega, Jorge Ruben; In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems; Springer; Polymer Bulletin; 73; 1; 1-2016; 209-227
0170-0839
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23816
identifier_str_mv Boimvaser, Sonia; Mariano, Rodolfo Nicolás; Turino, Ludmila Noelia; Vega, Jorge Ruben; In vitro bulk/surface erosion pattern of PLGA implant in physiological conditions: a study based on auxiliary microsphere systems; Springer; Polymer Bulletin; 73; 1; 1-2016; 209-227
0170-0839
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00289-015-1481-6
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00289-015-1481-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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