Porous PVA microspheres for Oxytetracycline delivery

Autores
Verón, María Gisela; Álvarez Soria, Joaquín; Pérez, Pablo Daniel; Prado, Miguel Oscar
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Porous PVA microspheres were prepared to investigate their adsorption and release capacity ofoxytetracycline (OTC) in simulated biological fluid (SBF). The highest adsorption capacity of OTC during 2 hours was obtained at pH= 4, being 0.9 mg g-1. The release profile of OTC in SBF from the microspheres showed a burst effect with a cumulative release of 29±4 % within the first thirty minutes due to the immediate release of the OTC adsorbed on the surface of the microspheres, followed by a slower release reaching 41±5% within two hours,which in terms of concentration is equivalent to 4.2 μg/mL, a value close to the minimum inhibitory concentration of pathogens susceptible to OTC in injectable administration methods of therapeutic doses from 10 mg/Kg for farm animals.
Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Álvarez Soria, Joaquín. Universidad Nacional de Río Negro. Sede Andina; Argentina
Fil: Pérez, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Materia
POLYVINYL ALCOHOL
MICROSPHERES
OXYTETRACYCLINE
DRUG DELIVERY
BIOPOLYMERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/236223
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Porous PVA microspheres for Oxytetracycline deliveryVerón, María GiselaÁlvarez Soria, JoaquínPérez, Pablo DanielPrado, Miguel OscarPOLYVINYL ALCOHOLMICROSPHERESOXYTETRACYCLINEDRUG DELIVERYBIOPOLYMERShttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Porous PVA microspheres were prepared to investigate their adsorption and release capacity ofoxytetracycline (OTC) in simulated biological fluid (SBF). The highest adsorption capacity of OTC during 2 hours was obtained at pH= 4, being 0.9 mg g-1. The release profile of OTC in SBF from the microspheres showed a burst effect with a cumulative release of 29±4 % within the first thirty minutes due to the immediate release of the OTC adsorbed on the surface of the microspheres, followed by a slower release reaching 41±5% within two hours,which in terms of concentration is equivalent to 4.2 μg/mL, a value close to the minimum inhibitory concentration of pathogens susceptible to OTC in injectable administration methods of therapeutic doses from 10 mg/Kg for farm animals.Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Álvarez Soria, Joaquín. Universidad Nacional de Río Negro. Sede Andina; ArgentinaFil: Pérez, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaInventy2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/236223Verón, María Gisela; Álvarez Soria, Joaquín; Pérez, Pablo Daniel; Prado, Miguel Oscar; Porous PVA microspheres for Oxytetracycline delivery; Inventy; Research Inventy; 13; 12; 12-2023; 29-372319-64832278-4721CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://researchinventy.com/vol13-iss12.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:47Zoai:ri.conicet.gov.ar:11336/236223instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:47.861CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Porous PVA microspheres for Oxytetracycline delivery
title Porous PVA microspheres for Oxytetracycline delivery
spellingShingle Porous PVA microspheres for Oxytetracycline delivery
Verón, María Gisela
POLYVINYL ALCOHOL
MICROSPHERES
OXYTETRACYCLINE
DRUG DELIVERY
BIOPOLYMERS
title_short Porous PVA microspheres for Oxytetracycline delivery
title_full Porous PVA microspheres for Oxytetracycline delivery
title_fullStr Porous PVA microspheres for Oxytetracycline delivery
title_full_unstemmed Porous PVA microspheres for Oxytetracycline delivery
title_sort Porous PVA microspheres for Oxytetracycline delivery
dc.creator.none.fl_str_mv Verón, María Gisela
Álvarez Soria, Joaquín
Pérez, Pablo Daniel
Prado, Miguel Oscar
author Verón, María Gisela
author_facet Verón, María Gisela
Álvarez Soria, Joaquín
Pérez, Pablo Daniel
Prado, Miguel Oscar
author_role author
author2 Álvarez Soria, Joaquín
Pérez, Pablo Daniel
Prado, Miguel Oscar
author2_role author
author
author
dc.subject.none.fl_str_mv POLYVINYL ALCOHOL
MICROSPHERES
OXYTETRACYCLINE
DRUG DELIVERY
BIOPOLYMERS
topic POLYVINYL ALCOHOL
MICROSPHERES
OXYTETRACYCLINE
DRUG DELIVERY
BIOPOLYMERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Porous PVA microspheres were prepared to investigate their adsorption and release capacity ofoxytetracycline (OTC) in simulated biological fluid (SBF). The highest adsorption capacity of OTC during 2 hours was obtained at pH= 4, being 0.9 mg g-1. The release profile of OTC in SBF from the microspheres showed a burst effect with a cumulative release of 29±4 % within the first thirty minutes due to the immediate release of the OTC adsorbed on the surface of the microspheres, followed by a slower release reaching 41±5% within two hours,which in terms of concentration is equivalent to 4.2 μg/mL, a value close to the minimum inhibitory concentration of pathogens susceptible to OTC in injectable administration methods of therapeutic doses from 10 mg/Kg for farm animals.
Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Álvarez Soria, Joaquín. Universidad Nacional de Río Negro. Sede Andina; Argentina
Fil: Pérez, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
description Porous PVA microspheres were prepared to investigate their adsorption and release capacity ofoxytetracycline (OTC) in simulated biological fluid (SBF). The highest adsorption capacity of OTC during 2 hours was obtained at pH= 4, being 0.9 mg g-1. The release profile of OTC in SBF from the microspheres showed a burst effect with a cumulative release of 29±4 % within the first thirty minutes due to the immediate release of the OTC adsorbed on the surface of the microspheres, followed by a slower release reaching 41±5% within two hours,which in terms of concentration is equivalent to 4.2 μg/mL, a value close to the minimum inhibitory concentration of pathogens susceptible to OTC in injectable administration methods of therapeutic doses from 10 mg/Kg for farm animals.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/236223
Verón, María Gisela; Álvarez Soria, Joaquín; Pérez, Pablo Daniel; Prado, Miguel Oscar; Porous PVA microspheres for Oxytetracycline delivery; Inventy; Research Inventy; 13; 12; 12-2023; 29-37
2319-6483
2278-4721
CONICET Digital
CONICET
url http://hdl.handle.net/11336/236223
identifier_str_mv Verón, María Gisela; Álvarez Soria, Joaquín; Pérez, Pablo Daniel; Prado, Miguel Oscar; Porous PVA microspheres for Oxytetracycline delivery; Inventy; Research Inventy; 13; 12; 12-2023; 29-37
2319-6483
2278-4721
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://researchinventy.com/vol13-iss12.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Inventy
publisher.none.fl_str_mv Inventy
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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