Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus

Autores
Rey, Mariana; Kruse, Maria Sol; Magrini Huamán, Rocío Nahimé; Gómez, Jessica; Simirgiotis, Mario J.; Tapia, Alejandro; Feresin, Gabriela Egly; Coirini, Hector
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chronic high-fat diet consumption induces hypercholesterolemia. The effect of Tessariaabsinthioides (Hook. & Arn.) DC. (Asteraceae) was studied on the levels of total cholesterol (TC),high-density lipoprotein cholesterol (HDL-c), and triglycerides, and on the expression of liver Xreceptors (LXRs) in a hypercholesterolemic model. Adult male rats received a normal diet (ND) or ahigh-fat diet (HFD; normal diet + bovine fat + cholesterol). After 14 days, rats received water (W)or a decoction of the aerial parts of T. absinthioides (Ta; 10% w/v) for 2, 4, or 6 weeks. Four and sixweeks of Ta improved the levels of TC and HDL-c in HFD. After 6 weeks of Ta, the expression ofLXRs in HFD was the same as that in ND in both tissues. The Ta chemical profile was studied withan ultrahigh resolution liquid chromatography Orbitrap MS analysis (UHPLC?PDA?OT-MS/MS).Fifty-one compounds were identified, of which twelve are reported for the first time. Among thesecompounds, caffeoylquinic acid and its derivatives could modify the lipid profile and the expressionof LXRs. This is the first in vivo report of T. absinthioides, which may be a potential candidateagainst hypercholesterolemia.
Fil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Magrini Huamán, Rocío Nahimé. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Universidad Católica de Cuyo - Sede San Juan; Argentina
Fil: Gómez, Jessica. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Simirgiotis, Mario J.. Universidad Austral de Chile; Chile
Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
BRAIN LIPID METABOLISM
CAFFEOYLQUINIC ACID
DIETARY FAT
NUCLEAR RECEPTORS (LXR, PPAR, RXR)
UHPLC-PDA-OT-MS/MS PHENOLIC COMPOUNDS ANALYSIS
TRIGLYCERIDE METABOLISM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/158525
Acceder
id CONICETDig_51d39fdce6a37c3e62dec7d16cde388f
oai_identifier_str oai:ri.conicet.gov.ar:11336/158525
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and HypothalamusRey, MarianaKruse, Maria SolMagrini Huamán, Rocío NahiméGómez, JessicaSimirgiotis, Mario J.Tapia, AlejandroFeresin, Gabriela EglyCoirini, HectorBRAIN LIPID METABOLISMCAFFEOYLQUINIC ACIDDIETARY FATNUCLEAR RECEPTORS (LXR, PPAR, RXR)UHPLC-PDA-OT-MS/MS PHENOLIC COMPOUNDS ANALYSISTRIGLYCERIDE METABOLISMhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Chronic high-fat diet consumption induces hypercholesterolemia. The effect of Tessariaabsinthioides (Hook. & Arn.) DC. (Asteraceae) was studied on the levels of total cholesterol (TC),high-density lipoprotein cholesterol (HDL-c), and triglycerides, and on the expression of liver Xreceptors (LXRs) in a hypercholesterolemic model. Adult male rats received a normal diet (ND) or ahigh-fat diet (HFD; normal diet + bovine fat + cholesterol). After 14 days, rats received water (W)or a decoction of the aerial parts of T. absinthioides (Ta; 10% w/v) for 2, 4, or 6 weeks. Four and sixweeks of Ta improved the levels of TC and HDL-c in HFD. After 6 weeks of Ta, the expression ofLXRs in HFD was the same as that in ND in both tissues. The Ta chemical profile was studied withan ultrahigh resolution liquid chromatography Orbitrap MS analysis (UHPLC?PDA?OT-MS/MS).Fifty-one compounds were identified, of which twelve are reported for the first time. Among thesecompounds, caffeoylquinic acid and its derivatives could modify the lipid profile and the expressionof LXRs. This is the first in vivo report of T. absinthioides, which may be a potential candidateagainst hypercholesterolemia.Fil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Magrini Huamán, Rocío Nahimé. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Universidad Católica de Cuyo - Sede San Juan; ArgentinaFil: Gómez, Jessica. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Simirgiotis, Mario J.. Universidad Austral de Chile; ChileFil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaMDPI2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/158525Rey, Mariana; Kruse, Maria Sol; Magrini Huamán, Rocío Nahimé; Gómez, Jessica; Simirgiotis, Mario J.; et al.; Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus; MDPI; Metabolites; 11; 9; 8-2021; 1-162218-19892218-1989CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-1989/11/9/579info:eu-repo/semantics/altIdentifier/doi/10.3390/metabo11090579info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:09:21Zoai:ri.conicet.gov.ar:11336/158525instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:09:22.125CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
title Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
spellingShingle Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
Rey, Mariana
BRAIN LIPID METABOLISM
CAFFEOYLQUINIC ACID
DIETARY FAT
NUCLEAR RECEPTORS (LXR, PPAR, RXR)
UHPLC-PDA-OT-MS/MS PHENOLIC COMPOUNDS ANALYSIS
TRIGLYCERIDE METABOLISM
title_short Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
title_full Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
title_fullStr Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
title_full_unstemmed Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
title_sort Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus
dc.creator.none.fl_str_mv Rey, Mariana
Kruse, Maria Sol
Magrini Huamán, Rocío Nahimé
Gómez, Jessica
Simirgiotis, Mario J.
Tapia, Alejandro
Feresin, Gabriela Egly
Coirini, Hector
author Rey, Mariana
author_facet Rey, Mariana
Kruse, Maria Sol
Magrini Huamán, Rocío Nahimé
Gómez, Jessica
Simirgiotis, Mario J.
Tapia, Alejandro
Feresin, Gabriela Egly
Coirini, Hector
author_role author
author2 Kruse, Maria Sol
Magrini Huamán, Rocío Nahimé
Gómez, Jessica
Simirgiotis, Mario J.
Tapia, Alejandro
Feresin, Gabriela Egly
Coirini, Hector
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BRAIN LIPID METABOLISM
CAFFEOYLQUINIC ACID
DIETARY FAT
NUCLEAR RECEPTORS (LXR, PPAR, RXR)
UHPLC-PDA-OT-MS/MS PHENOLIC COMPOUNDS ANALYSIS
TRIGLYCERIDE METABOLISM
topic BRAIN LIPID METABOLISM
CAFFEOYLQUINIC ACID
DIETARY FAT
NUCLEAR RECEPTORS (LXR, PPAR, RXR)
UHPLC-PDA-OT-MS/MS PHENOLIC COMPOUNDS ANALYSIS
TRIGLYCERIDE METABOLISM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chronic high-fat diet consumption induces hypercholesterolemia. The effect of Tessariaabsinthioides (Hook. & Arn.) DC. (Asteraceae) was studied on the levels of total cholesterol (TC),high-density lipoprotein cholesterol (HDL-c), and triglycerides, and on the expression of liver Xreceptors (LXRs) in a hypercholesterolemic model. Adult male rats received a normal diet (ND) or ahigh-fat diet (HFD; normal diet + bovine fat + cholesterol). After 14 days, rats received water (W)or a decoction of the aerial parts of T. absinthioides (Ta; 10% w/v) for 2, 4, or 6 weeks. Four and sixweeks of Ta improved the levels of TC and HDL-c in HFD. After 6 weeks of Ta, the expression ofLXRs in HFD was the same as that in ND in both tissues. The Ta chemical profile was studied withan ultrahigh resolution liquid chromatography Orbitrap MS analysis (UHPLC?PDA?OT-MS/MS).Fifty-one compounds were identified, of which twelve are reported for the first time. Among thesecompounds, caffeoylquinic acid and its derivatives could modify the lipid profile and the expressionof LXRs. This is the first in vivo report of T. absinthioides, which may be a potential candidateagainst hypercholesterolemia.
Fil: Rey, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Kruse, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Magrini Huamán, Rocío Nahimé. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Universidad Católica de Cuyo - Sede San Juan; Argentina
Fil: Gómez, Jessica. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Simirgiotis, Mario J.. Universidad Austral de Chile; Chile
Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Coirini, Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Chronic high-fat diet consumption induces hypercholesterolemia. The effect of Tessariaabsinthioides (Hook. & Arn.) DC. (Asteraceae) was studied on the levels of total cholesterol (TC),high-density lipoprotein cholesterol (HDL-c), and triglycerides, and on the expression of liver Xreceptors (LXRs) in a hypercholesterolemic model. Adult male rats received a normal diet (ND) or ahigh-fat diet (HFD; normal diet + bovine fat + cholesterol). After 14 days, rats received water (W)or a decoction of the aerial parts of T. absinthioides (Ta; 10% w/v) for 2, 4, or 6 weeks. Four and sixweeks of Ta improved the levels of TC and HDL-c in HFD. After 6 weeks of Ta, the expression ofLXRs in HFD was the same as that in ND in both tissues. The Ta chemical profile was studied withan ultrahigh resolution liquid chromatography Orbitrap MS analysis (UHPLC?PDA?OT-MS/MS).Fifty-one compounds were identified, of which twelve are reported for the first time. Among thesecompounds, caffeoylquinic acid and its derivatives could modify the lipid profile and the expressionof LXRs. This is the first in vivo report of T. absinthioides, which may be a potential candidateagainst hypercholesterolemia.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/158525
Rey, Mariana; Kruse, Maria Sol; Magrini Huamán, Rocío Nahimé; Gómez, Jessica; Simirgiotis, Mario J.; et al.; Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus; MDPI; Metabolites; 11; 9; 8-2021; 1-16
2218-1989
2218-1989
CONICET Digital
CONICET
url http://hdl.handle.net/11336/158525
identifier_str_mv Rey, Mariana; Kruse, Maria Sol; Magrini Huamán, Rocío Nahimé; Gómez, Jessica; Simirgiotis, Mario J.; et al.; Tessaria absinthioides (Hook. & Arn.) DC. (Asteraceae) Decoction: Improves the Hypercholesterolemia and Alters the Expression of LXRs in Rat Liver and Hypothalamus; MDPI; Metabolites; 11; 9; 8-2021; 1-16
2218-1989
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-1989/11/9/579
info:eu-repo/semantics/altIdentifier/doi/10.3390/metabo11090579
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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