Update on the Oxidative Stress Associated with Arsenic Exposure

Autores
Bonetto, Julián Gerardo; Villaamil Lepori, Edda Cristina; Puntarulo, Susana Ángela
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Even though oxidative stress is currently widely accepted as a factor in As toxicity in both the liver and kidney, the mechanisms are not yet clearly understood. It has been suggested that As may induce oxidative stress by cycling between oxidation states of metals such as Fe, or by interacting with antioxidants and increasing inflammation, resulting in the accumulation of free radicals in cells. Major As-induced reactive oxygen species (ROS) include superoxide anion (O2 −), hydroxyl radical (?OH), hydrogen peroxide (H2O2), singlet oxygen (1O2), and peroxyl radicals. On the other hand, molecular oxygen reacts with dimethylarsine (a trivalent As form and a minor in vivo metabolite of dimethylarsinic acid) to form dimethylarsinic radical and O2¯. Further, the addition of another molecule of molecular oxygen may result in a dimethylarsinic peroxyl radical and these As radicals are known to be detrimental to cells. It has been shown that As induced free radical formation in mouse livers. Experimental results have shown the generation of O2¯ and H2O2 after As exposure in some cell lines such as human vascular smooth muscle cells, human-hamster hybrid cells, and vascular endothelial cells. Whereas, induction of H2O2 have been shown in other cell lines such as HEL30, NB4, and CHOK1 after exposure to As. The objective of the present review is to summarize the current knowledge on the role of oxidative stress in As toxicity in brain.
Fil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Toxicología y Química Legal; Argentina
Fil: Villaamil Lepori, Edda Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Toxicología y Química Legal; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Materia
ROS
Arsenic
Human health
Brain
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30797
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Update on the Oxidative Stress Associated with Arsenic ExposureBonetto, Julián GerardoVillaamil Lepori, Edda CristinaPuntarulo, Susana ÁngelaROSArsenicHuman healthBrainhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Even though oxidative stress is currently widely accepted as a factor in As toxicity in both the liver and kidney, the mechanisms are not yet clearly understood. It has been suggested that As may induce oxidative stress by cycling between oxidation states of metals such as Fe, or by interacting with antioxidants and increasing inflammation, resulting in the accumulation of free radicals in cells. Major As-induced reactive oxygen species (ROS) include superoxide anion (O2 −), hydroxyl radical (?OH), hydrogen peroxide (H2O2), singlet oxygen (1O2), and peroxyl radicals. On the other hand, molecular oxygen reacts with dimethylarsine (a trivalent As form and a minor in vivo metabolite of dimethylarsinic acid) to form dimethylarsinic radical and O2¯. Further, the addition of another molecule of molecular oxygen may result in a dimethylarsinic peroxyl radical and these As radicals are known to be detrimental to cells. It has been shown that As induced free radical formation in mouse livers. Experimental results have shown the generation of O2¯ and H2O2 after As exposure in some cell lines such as human vascular smooth muscle cells, human-hamster hybrid cells, and vascular endothelial cells. Whereas, induction of H2O2 have been shown in other cell lines such as HEL30, NB4, and CHOK1 after exposure to As. The objective of the present review is to summarize the current knowledge on the role of oxidative stress in As toxicity in brain.Fil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Toxicología y Química Legal; ArgentinaFil: Villaamil Lepori, Edda Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Toxicología y Química Legal; ArgentinaFil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaResearch Trends2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30797Puntarulo, Susana Ángela; Villaamil Lepori, Edda Cristina; Bonetto, Julián Gerardo; Update on the Oxidative Stress Associated with Arsenic Exposure; Research Trends; Current Topics in Toxicology; 10; 12-2014; 37-480972-8228CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=10&tid=50&aid=5556&pub=2014&type=3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:14Zoai:ri.conicet.gov.ar:11336/30797instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:15.246CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Update on the Oxidative Stress Associated with Arsenic Exposure
title Update on the Oxidative Stress Associated with Arsenic Exposure
spellingShingle Update on the Oxidative Stress Associated with Arsenic Exposure
Bonetto, Julián Gerardo
ROS
Arsenic
Human health
Brain
title_short Update on the Oxidative Stress Associated with Arsenic Exposure
title_full Update on the Oxidative Stress Associated with Arsenic Exposure
title_fullStr Update on the Oxidative Stress Associated with Arsenic Exposure
title_full_unstemmed Update on the Oxidative Stress Associated with Arsenic Exposure
title_sort Update on the Oxidative Stress Associated with Arsenic Exposure
dc.creator.none.fl_str_mv Bonetto, Julián Gerardo
Villaamil Lepori, Edda Cristina
Puntarulo, Susana Ángela
author Bonetto, Julián Gerardo
author_facet Bonetto, Julián Gerardo
Villaamil Lepori, Edda Cristina
Puntarulo, Susana Ángela
author_role author
author2 Villaamil Lepori, Edda Cristina
Puntarulo, Susana Ángela
author2_role author
author
dc.subject.none.fl_str_mv ROS
Arsenic
Human health
Brain
topic ROS
Arsenic
Human health
Brain
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Even though oxidative stress is currently widely accepted as a factor in As toxicity in both the liver and kidney, the mechanisms are not yet clearly understood. It has been suggested that As may induce oxidative stress by cycling between oxidation states of metals such as Fe, or by interacting with antioxidants and increasing inflammation, resulting in the accumulation of free radicals in cells. Major As-induced reactive oxygen species (ROS) include superoxide anion (O2 −), hydroxyl radical (?OH), hydrogen peroxide (H2O2), singlet oxygen (1O2), and peroxyl radicals. On the other hand, molecular oxygen reacts with dimethylarsine (a trivalent As form and a minor in vivo metabolite of dimethylarsinic acid) to form dimethylarsinic radical and O2¯. Further, the addition of another molecule of molecular oxygen may result in a dimethylarsinic peroxyl radical and these As radicals are known to be detrimental to cells. It has been shown that As induced free radical formation in mouse livers. Experimental results have shown the generation of O2¯ and H2O2 after As exposure in some cell lines such as human vascular smooth muscle cells, human-hamster hybrid cells, and vascular endothelial cells. Whereas, induction of H2O2 have been shown in other cell lines such as HEL30, NB4, and CHOK1 after exposure to As. The objective of the present review is to summarize the current knowledge on the role of oxidative stress in As toxicity in brain.
Fil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Toxicología y Química Legal; Argentina
Fil: Villaamil Lepori, Edda Cristina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Toxicología y Química Legal; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
description Even though oxidative stress is currently widely accepted as a factor in As toxicity in both the liver and kidney, the mechanisms are not yet clearly understood. It has been suggested that As may induce oxidative stress by cycling between oxidation states of metals such as Fe, or by interacting with antioxidants and increasing inflammation, resulting in the accumulation of free radicals in cells. Major As-induced reactive oxygen species (ROS) include superoxide anion (O2 −), hydroxyl radical (?OH), hydrogen peroxide (H2O2), singlet oxygen (1O2), and peroxyl radicals. On the other hand, molecular oxygen reacts with dimethylarsine (a trivalent As form and a minor in vivo metabolite of dimethylarsinic acid) to form dimethylarsinic radical and O2¯. Further, the addition of another molecule of molecular oxygen may result in a dimethylarsinic peroxyl radical and these As radicals are known to be detrimental to cells. It has been shown that As induced free radical formation in mouse livers. Experimental results have shown the generation of O2¯ and H2O2 after As exposure in some cell lines such as human vascular smooth muscle cells, human-hamster hybrid cells, and vascular endothelial cells. Whereas, induction of H2O2 have been shown in other cell lines such as HEL30, NB4, and CHOK1 after exposure to As. The objective of the present review is to summarize the current knowledge on the role of oxidative stress in As toxicity in brain.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30797
Puntarulo, Susana Ángela; Villaamil Lepori, Edda Cristina; Bonetto, Julián Gerardo; Update on the Oxidative Stress Associated with Arsenic Exposure; Research Trends; Current Topics in Toxicology; 10; 12-2014; 37-48
0972-8228
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30797
identifier_str_mv Puntarulo, Susana Ángela; Villaamil Lepori, Edda Cristina; Bonetto, Julián Gerardo; Update on the Oxidative Stress Associated with Arsenic Exposure; Research Trends; Current Topics in Toxicology; 10; 12-2014; 37-48
0972-8228
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=10&tid=50&aid=5556&pub=2014&type=3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Trends
publisher.none.fl_str_mv Research Trends
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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