Animal models of postpartum depresion revisited

Autores
Mir, Franco Rafael; Pollano, Antonella; Rivarola, María Angélica
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Postpartum depression (PPD) is a heterogeneous mood disorder and the most frequent psychiatric complicationof the postnatal period. Given its potential long-lasting repercussions on the well-being of the mother and theinfants, it should be a priority in public health. In spite of efforts devoted to clinical investigation and preclinicalstudies, the underlying neurobiological mechanisms of this disorder remain unknown in detail. Much of theprogress in the area has been made from animal models, especially rodent models. The aim of this mini-review isto update the current rodent models in PPD research and their main contributions to the field. Animal models arecritical tools to advance understanding of the pathophysiological basis of this disorder and to help the development of new therapeutic strategies. Here, we group PPD models into 2 main categories (Models based onhormone manipulations, Models based on stress exposure), each of which includes different paradigms thatreflect risk factors or physiological conditions associated with this disease. Finally, we provide an overview ofemerging models that provide new perspectives on the study of possible pathophysiological factors related toPPD, to contribute to tackling potential therapeutic targets.
Fil: Mir, Franco Rafael. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Pollano, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Rivarola, María Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
PSTPARTUM DEPRESION
ANIMAL MODELS
FEMALE MENTAL HEALTH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/255914
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Animal models of postpartum depresion revisitedMir, Franco RafaelPollano, AntonellaRivarola, María AngélicaPSTPARTUM DEPRESIONANIMAL MODELSFEMALE MENTAL HEALTHhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Postpartum depression (PPD) is a heterogeneous mood disorder and the most frequent psychiatric complicationof the postnatal period. Given its potential long-lasting repercussions on the well-being of the mother and theinfants, it should be a priority in public health. In spite of efforts devoted to clinical investigation and preclinicalstudies, the underlying neurobiological mechanisms of this disorder remain unknown in detail. Much of theprogress in the area has been made from animal models, especially rodent models. The aim of this mini-review isto update the current rodent models in PPD research and their main contributions to the field. Animal models arecritical tools to advance understanding of the pathophysiological basis of this disorder and to help the development of new therapeutic strategies. Here, we group PPD models into 2 main categories (Models based onhormone manipulations, Models based on stress exposure), each of which includes different paradigms thatreflect risk factors or physiological conditions associated with this disease. Finally, we provide an overview ofemerging models that provide new perspectives on the study of possible pathophysiological factors related toPPD, to contribute to tackling potential therapeutic targets.Fil: Mir, Franco Rafael. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Pollano, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Rivarola, María Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaPergamon-Elsevier Science Ltd2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/255914Mir, Franco Rafael; Pollano, Antonella; Rivarola, María Angélica; Animal models of postpartum depresion revisited; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 136; 12-2021; 1-510306-4530CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0306453021004649info:eu-repo/semantics/altIdentifier/doi/10.1016/j.psyneuen.2021.105590info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:19Zoai:ri.conicet.gov.ar:11336/255914instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:19.611CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Animal models of postpartum depresion revisited
title Animal models of postpartum depresion revisited
spellingShingle Animal models of postpartum depresion revisited
Mir, Franco Rafael
PSTPARTUM DEPRESION
ANIMAL MODELS
FEMALE MENTAL HEALTH
title_short Animal models of postpartum depresion revisited
title_full Animal models of postpartum depresion revisited
title_fullStr Animal models of postpartum depresion revisited
title_full_unstemmed Animal models of postpartum depresion revisited
title_sort Animal models of postpartum depresion revisited
dc.creator.none.fl_str_mv Mir, Franco Rafael
Pollano, Antonella
Rivarola, María Angélica
author Mir, Franco Rafael
author_facet Mir, Franco Rafael
Pollano, Antonella
Rivarola, María Angélica
author_role author
author2 Pollano, Antonella
Rivarola, María Angélica
author2_role author
author
dc.subject.none.fl_str_mv PSTPARTUM DEPRESION
ANIMAL MODELS
FEMALE MENTAL HEALTH
topic PSTPARTUM DEPRESION
ANIMAL MODELS
FEMALE MENTAL HEALTH
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Postpartum depression (PPD) is a heterogeneous mood disorder and the most frequent psychiatric complicationof the postnatal period. Given its potential long-lasting repercussions on the well-being of the mother and theinfants, it should be a priority in public health. In spite of efforts devoted to clinical investigation and preclinicalstudies, the underlying neurobiological mechanisms of this disorder remain unknown in detail. Much of theprogress in the area has been made from animal models, especially rodent models. The aim of this mini-review isto update the current rodent models in PPD research and their main contributions to the field. Animal models arecritical tools to advance understanding of the pathophysiological basis of this disorder and to help the development of new therapeutic strategies. Here, we group PPD models into 2 main categories (Models based onhormone manipulations, Models based on stress exposure), each of which includes different paradigms thatreflect risk factors or physiological conditions associated with this disease. Finally, we provide an overview ofemerging models that provide new perspectives on the study of possible pathophysiological factors related toPPD, to contribute to tackling potential therapeutic targets.
Fil: Mir, Franco Rafael. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Pollano, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Rivarola, María Angélica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description Postpartum depression (PPD) is a heterogeneous mood disorder and the most frequent psychiatric complicationof the postnatal period. Given its potential long-lasting repercussions on the well-being of the mother and theinfants, it should be a priority in public health. In spite of efforts devoted to clinical investigation and preclinicalstudies, the underlying neurobiological mechanisms of this disorder remain unknown in detail. Much of theprogress in the area has been made from animal models, especially rodent models. The aim of this mini-review isto update the current rodent models in PPD research and their main contributions to the field. Animal models arecritical tools to advance understanding of the pathophysiological basis of this disorder and to help the development of new therapeutic strategies. Here, we group PPD models into 2 main categories (Models based onhormone manipulations, Models based on stress exposure), each of which includes different paradigms thatreflect risk factors or physiological conditions associated with this disease. Finally, we provide an overview ofemerging models that provide new perspectives on the study of possible pathophysiological factors related toPPD, to contribute to tackling potential therapeutic targets.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/255914
Mir, Franco Rafael; Pollano, Antonella; Rivarola, María Angélica; Animal models of postpartum depresion revisited; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 136; 12-2021; 1-51
0306-4530
CONICET Digital
CONICET
url http://hdl.handle.net/11336/255914
identifier_str_mv Mir, Franco Rafael; Pollano, Antonella; Rivarola, María Angélica; Animal models of postpartum depresion revisited; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 136; 12-2021; 1-51
0306-4530
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0306453021004649
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.psyneuen.2021.105590
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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