Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation

Autores
Rabinovich, Gabriel Adrián; Toscano, Marta Alicia
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine-containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family.
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
Glycoimmunology
Galectins
Adaptive Immunity
Tolerance
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24530
Acceder
id CONICETDig_43b7ab812bc02c4cb96e68f6b58c07d7
oai_identifier_str oai:ri.conicet.gov.ar:11336/24530
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammationRabinovich, Gabriel AdriánToscano, Marta AliciaGlycoimmunologyGalectinsAdaptive ImmunityTolerancehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine-containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family.Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaMacmillan Publisher Limited2009-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24530Rabinovich, Gabriel Adrián; Toscano, Marta Alicia; Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation; Macmillan Publisher Limited; Nature Reviews Immunology; 9; 5; 5-2009; 338-3521474-17331474-1741CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nri/journal/v9/n5/full/nri2536.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1038/nri2536info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:24Zoai:ri.conicet.gov.ar:11336/24530instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:24.729CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
title Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
spellingShingle Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
Rabinovich, Gabriel Adrián
Glycoimmunology
Galectins
Adaptive Immunity
Tolerance
title_short Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
title_full Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
title_fullStr Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
title_full_unstemmed Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
title_sort Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
dc.creator.none.fl_str_mv Rabinovich, Gabriel Adrián
Toscano, Marta Alicia
author Rabinovich, Gabriel Adrián
author_facet Rabinovich, Gabriel Adrián
Toscano, Marta Alicia
author_role author
author2 Toscano, Marta Alicia
author2_role author
dc.subject.none.fl_str_mv Glycoimmunology
Galectins
Adaptive Immunity
Tolerance
topic Glycoimmunology
Galectins
Adaptive Immunity
Tolerance
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine-containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family.
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Toscano, Marta Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine-containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family.
publishDate 2009
dc.date.none.fl_str_mv 2009-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24530
Rabinovich, Gabriel Adrián; Toscano, Marta Alicia; Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation; Macmillan Publisher Limited; Nature Reviews Immunology; 9; 5; 5-2009; 338-352
1474-1733
1474-1741
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24530
identifier_str_mv Rabinovich, Gabriel Adrián; Toscano, Marta Alicia; Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation; Macmillan Publisher Limited; Nature Reviews Immunology; 9; 5; 5-2009; 338-352
1474-1733
1474-1741
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nri/journal/v9/n5/full/nri2536.html
info:eu-repo/semantics/altIdentifier/doi/10.1038/nri2536
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Macmillan Publisher Limited
publisher.none.fl_str_mv Macmillan Publisher Limited
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269285066473472
score 13.13397

Publicaciones similares