Galectins: regulators of acute and chronic inflammation
- Autores
- Liu, Fu-Tong; Rabinovich, Gabriel Adrian
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with cell surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell surface glycoprotein receptors, resulting in modulation of receptor functions including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biological responses. These include apoptosis, cell differentiation and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for these proteins’ contributions to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be employed as therapeutic agents for inflammatory diseases.
Fil: Liu, Fu-Tong . University Of California At Davis; Estados Unidos
Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina - Materia
-
Galectins
Inflammation
Immunity - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/14677
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Galectins: regulators of acute and chronic inflammationLiu, Fu-Tong Rabinovich, Gabriel AdrianGalectinsInflammationImmunityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with cell surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell surface glycoprotein receptors, resulting in modulation of receptor functions including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biological responses. These include apoptosis, cell differentiation and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for these proteins’ contributions to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be employed as therapeutic agents for inflammatory diseases.Fil: Liu, Fu-Tong . University Of California At Davis; Estados UnidosFil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaWiley2010-01-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14677Liu, Fu-Tong ; Rabinovich, Gabriel Adrian; Galectins: regulators of acute and chronic inflammation; Wiley; Annals Of The New York Academy Of Sciences.; 1183; 12-1-2010; 158-1820077-89231749-6632enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.05131.x/abstractinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1111/j.1749-6632.2009.05131.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:55Zoai:ri.conicet.gov.ar:11336/14677instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:55.269CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Galectins: regulators of acute and chronic inflammation |
title |
Galectins: regulators of acute and chronic inflammation |
spellingShingle |
Galectins: regulators of acute and chronic inflammation Liu, Fu-Tong Galectins Inflammation Immunity |
title_short |
Galectins: regulators of acute and chronic inflammation |
title_full |
Galectins: regulators of acute and chronic inflammation |
title_fullStr |
Galectins: regulators of acute and chronic inflammation |
title_full_unstemmed |
Galectins: regulators of acute and chronic inflammation |
title_sort |
Galectins: regulators of acute and chronic inflammation |
dc.creator.none.fl_str_mv |
Liu, Fu-Tong Rabinovich, Gabriel Adrian |
author |
Liu, Fu-Tong |
author_facet |
Liu, Fu-Tong Rabinovich, Gabriel Adrian |
author_role |
author |
author2 |
Rabinovich, Gabriel Adrian |
author2_role |
author |
dc.subject.none.fl_str_mv |
Galectins Inflammation Immunity |
topic |
Galectins Inflammation Immunity |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with cell surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell surface glycoprotein receptors, resulting in modulation of receptor functions including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biological responses. These include apoptosis, cell differentiation and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for these proteins’ contributions to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be employed as therapeutic agents for inflammatory diseases. Fil: Liu, Fu-Tong . University Of California At Davis; Estados Unidos Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina |
description |
B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with cell surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell surface glycoprotein receptors, resulting in modulation of receptor functions including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biological responses. These include apoptosis, cell differentiation and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for these proteins’ contributions to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be employed as therapeutic agents for inflammatory diseases. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/14677 Liu, Fu-Tong ; Rabinovich, Gabriel Adrian; Galectins: regulators of acute and chronic inflammation; Wiley; Annals Of The New York Academy Of Sciences.; 1183; 12-1-2010; 158-182 0077-8923 1749-6632 |
url |
http://hdl.handle.net/11336/14677 |
identifier_str_mv |
Liu, Fu-Tong ; Rabinovich, Gabriel Adrian; Galectins: regulators of acute and chronic inflammation; Wiley; Annals Of The New York Academy Of Sciences.; 1183; 12-1-2010; 158-182 0077-8923 1749-6632 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.05131.x/abstract info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1111/j.1749-6632.2009.05131.x |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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