Galectins: regulators of acute and chronic inflammation

Autores
Liu, Fu-Tong; Rabinovich, Gabriel Adrian
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with cell surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell surface glycoprotein receptors, resulting in modulation of receptor functions including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biological responses. These include apoptosis, cell differentiation and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for these proteins’ contributions to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be employed as therapeutic agents for inflammatory diseases.
Fil: Liu, Fu-Tong . University Of California At Davis; Estados Unidos
Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Materia
Galectins
Inflammation
Immunity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14677

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spelling Galectins: regulators of acute and chronic inflammationLiu, Fu-Tong Rabinovich, Gabriel AdrianGalectinsInflammationImmunityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with cell surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell surface glycoprotein receptors, resulting in modulation of receptor functions including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biological responses. These include apoptosis, cell differentiation and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for these proteins’ contributions to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be employed as therapeutic agents for inflammatory diseases.Fil: Liu, Fu-Tong . University Of California At Davis; Estados UnidosFil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaWiley2010-01-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14677Liu, Fu-Tong ; Rabinovich, Gabriel Adrian; Galectins: regulators of acute and chronic inflammation; Wiley; Annals Of The New York Academy Of Sciences.; 1183; 12-1-2010; 158-1820077-89231749-6632enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.05131.x/abstractinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1111/j.1749-6632.2009.05131.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:55Zoai:ri.conicet.gov.ar:11336/14677instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:55.269CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Galectins: regulators of acute and chronic inflammation
title Galectins: regulators of acute and chronic inflammation
spellingShingle Galectins: regulators of acute and chronic inflammation
Liu, Fu-Tong
Galectins
Inflammation
Immunity
title_short Galectins: regulators of acute and chronic inflammation
title_full Galectins: regulators of acute and chronic inflammation
title_fullStr Galectins: regulators of acute and chronic inflammation
title_full_unstemmed Galectins: regulators of acute and chronic inflammation
title_sort Galectins: regulators of acute and chronic inflammation
dc.creator.none.fl_str_mv Liu, Fu-Tong
Rabinovich, Gabriel Adrian
author Liu, Fu-Tong
author_facet Liu, Fu-Tong
Rabinovich, Gabriel Adrian
author_role author
author2 Rabinovich, Gabriel Adrian
author2_role author
dc.subject.none.fl_str_mv Galectins
Inflammation
Immunity
topic Galectins
Inflammation
Immunity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with cell surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell surface glycoprotein receptors, resulting in modulation of receptor functions including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biological responses. These include apoptosis, cell differentiation and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for these proteins’ contributions to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be employed as therapeutic agents for inflammatory diseases.
Fil: Liu, Fu-Tong . University Of California At Davis; Estados Unidos
Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
description B-galactoside-binding animal lectins, are differentially expressed by various immune cells, as well as a wide range of other cell types. Extracellularly, they are able to exhibit bivalent or multivalent interactions with cell surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell surface glycoprotein receptors, resulting in modulation of receptor functions including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biological responses. These include apoptosis, cell differentiation and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for these proteins’ contributions to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be employed as therapeutic agents for inflammatory diseases.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14677
Liu, Fu-Tong ; Rabinovich, Gabriel Adrian; Galectins: regulators of acute and chronic inflammation; Wiley; Annals Of The New York Academy Of Sciences.; 1183; 12-1-2010; 158-182
0077-8923
1749-6632
url http://hdl.handle.net/11336/14677
identifier_str_mv Liu, Fu-Tong ; Rabinovich, Gabriel Adrian; Galectins: regulators of acute and chronic inflammation; Wiley; Annals Of The New York Academy Of Sciences.; 1183; 12-1-2010; 158-182
0077-8923
1749-6632
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.05131.x/abstract
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1111/j.1749-6632.2009.05131.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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