Glycobiology of immune responses
- Autores
- Rabinovich, Gabriel Adrián; Van Kooyk, Yvette; Cobb, Brian A.
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Unlike their protein roommates and their nucleic acid cousins, carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function are tied is the non-template nature of their synthesis and the resulting heterogeneity. While this Annals of the NYAS issue does not claim to hold all of the answers, the goal is to highlight what is known about how carbohydrates and their binding partners, on the microbial (non-self), tumor (altered-self) and host (self) sides, cooperate within the immune system while identifying areas of great opportunity to those willing to take up the challenge. In the end, these reviews will serve as specific examples of how carbohydrates are as integral to biology as proteins, nucleic acids, and lipids. In this introductory article we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs and galectins) and their contribution to the biology of the immune responses in physiologic and pathologic settings.
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Van Kooyk, Yvette. VU University Amsterdam. VU University Medical Center; Países Bajos
Fil: Cobb, Brian A.. Case Western Reserve University; Estados Unidos - Materia
-
Glycobiology
Innate Immunity
Adaptive Immunity
Lectins - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/22663
Ver los metadatos del registro completo
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Glycobiology of immune responsesRabinovich, Gabriel AdriánVan Kooyk, YvetteCobb, Brian A.GlycobiologyInnate ImmunityAdaptive ImmunityLectinshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Unlike their protein roommates and their nucleic acid cousins, carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function are tied is the non-template nature of their synthesis and the resulting heterogeneity. While this Annals of the NYAS issue does not claim to hold all of the answers, the goal is to highlight what is known about how carbohydrates and their binding partners, on the microbial (non-self), tumor (altered-self) and host (self) sides, cooperate within the immune system while identifying areas of great opportunity to those willing to take up the challenge. In the end, these reviews will serve as specific examples of how carbohydrates are as integral to biology as proteins, nucleic acids, and lipids. In this introductory article we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs and galectins) and their contribution to the biology of the immune responses in physiologic and pathologic settings.Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Van Kooyk, Yvette. VU University Amsterdam. VU University Medical Center; Países BajosFil: Cobb, Brian A.. Case Western Reserve University; Estados UnidosJohn Wiley & Sons Inc2012-04-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22663Rabinovich, Gabriel Adrián; Van Kooyk, Yvette; Cobb, Brian A.; Glycobiology of immune responses; John Wiley & Sons Inc; Annals Of The New York Academy Of Sciences.; 1253; 23-4-2012; 1-150077-89231749-6632CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06492.x/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06492.xinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884643/pdf/nihms540634.pdfinfo:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:36Zoai:ri.conicet.gov.ar:11336/22663instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:36.645CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Glycobiology of immune responses |
title |
Glycobiology of immune responses |
spellingShingle |
Glycobiology of immune responses Rabinovich, Gabriel Adrián Glycobiology Innate Immunity Adaptive Immunity Lectins |
title_short |
Glycobiology of immune responses |
title_full |
Glycobiology of immune responses |
title_fullStr |
Glycobiology of immune responses |
title_full_unstemmed |
Glycobiology of immune responses |
title_sort |
Glycobiology of immune responses |
dc.creator.none.fl_str_mv |
Rabinovich, Gabriel Adrián Van Kooyk, Yvette Cobb, Brian A. |
author |
Rabinovich, Gabriel Adrián |
author_facet |
Rabinovich, Gabriel Adrián Van Kooyk, Yvette Cobb, Brian A. |
author_role |
author |
author2 |
Van Kooyk, Yvette Cobb, Brian A. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Glycobiology Innate Immunity Adaptive Immunity Lectins |
topic |
Glycobiology Innate Immunity Adaptive Immunity Lectins |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Unlike their protein roommates and their nucleic acid cousins, carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function are tied is the non-template nature of their synthesis and the resulting heterogeneity. While this Annals of the NYAS issue does not claim to hold all of the answers, the goal is to highlight what is known about how carbohydrates and their binding partners, on the microbial (non-self), tumor (altered-self) and host (self) sides, cooperate within the immune system while identifying areas of great opportunity to those willing to take up the challenge. In the end, these reviews will serve as specific examples of how carbohydrates are as integral to biology as proteins, nucleic acids, and lipids. In this introductory article we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs and galectins) and their contribution to the biology of the immune responses in physiologic and pathologic settings. Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Van Kooyk, Yvette. VU University Amsterdam. VU University Medical Center; Países Bajos Fil: Cobb, Brian A.. Case Western Reserve University; Estados Unidos |
description |
Unlike their protein roommates and their nucleic acid cousins, carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in fully understanding how carbohydrate structure and biological function are tied is the non-template nature of their synthesis and the resulting heterogeneity. While this Annals of the NYAS issue does not claim to hold all of the answers, the goal is to highlight what is known about how carbohydrates and their binding partners, on the microbial (non-self), tumor (altered-self) and host (self) sides, cooperate within the immune system while identifying areas of great opportunity to those willing to take up the challenge. In the end, these reviews will serve as specific examples of how carbohydrates are as integral to biology as proteins, nucleic acids, and lipids. In this introductory article we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs and galectins) and their contribution to the biology of the immune responses in physiologic and pathologic settings. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-23 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/22663 Rabinovich, Gabriel Adrián; Van Kooyk, Yvette; Cobb, Brian A.; Glycobiology of immune responses; John Wiley & Sons Inc; Annals Of The New York Academy Of Sciences.; 1253; 23-4-2012; 1-15 0077-8923 1749-6632 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/22663 |
identifier_str_mv |
Rabinovich, Gabriel Adrián; Van Kooyk, Yvette; Cobb, Brian A.; Glycobiology of immune responses; John Wiley & Sons Inc; Annals Of The New York Academy Of Sciences.; 1253; 23-4-2012; 1-15 0077-8923 1749-6632 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06492.x/abstract info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06492.x info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884643/pdf/nihms540634.pdf |
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openAccess |
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Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR) https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf application/pdf application/pdf |
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John Wiley & Sons Inc |
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John Wiley & Sons Inc |
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