The role of oxidative stress in the pathophysiology of gestational diabetes mellitus

Autores
Lappas, Martha; Hiden, Ursula; Desoye, Gernot; Froehlich, Julia; Hauguel de Mouzon, Sylvie; Jawerbaum, Alicia Sandra
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy, it plays important roles in embryo development, implantation, placental development and function, fetal development, and labor. However, pathologic pregnancies, including gestational diabetes mellitus (GDM), are associated with a heightened level of oxidative stress, owing to both overproduction of free radicals and/or a defect in the antioxidant defenses. This has important implications on the mother, placental function, and fetal well-being. Animal models of diabetes have confirmed the important role of oxidative stress in the etiology of congenital malformations; the relative immaturity of the antioxidant system facilitates the exposure of embryos and fetuses to the damaging effects of oxidative stress. Of note, there are only a few clinical studies evaluating the potential beneficial effects of antioxidants in GDM. Thus, whether or not increased antioxidant intake can reduce the complications of GDM in both mother and fetus needs to be explored. This review provides an overview and updated data on our current understanding of the complications associated with oxidative changes in GDM.
Fil: Lappas, Martha. The University of Melbourne; Australia
Fil: Hiden, Ursula. University of Graz; Austria
Fil: Desoye, Gernot. University of Graz; Austria
Fil: Froehlich, Julia. University of Graz; Austria
Fil: Hauguel de Mouzon, Sylvie. Case Western Reserve University; Estados Unidos
Fil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
Diabetes
Pregnancy
Oxidative Stress
Placenta
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17444
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The role of oxidative stress in the pathophysiology of gestational diabetes mellitusLappas, MarthaHiden, UrsulaDesoye, GernotFroehlich, JuliaHauguel de Mouzon, SylvieJawerbaum, Alicia SandraDiabetesPregnancyOxidative StressPlacentahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy, it plays important roles in embryo development, implantation, placental development and function, fetal development, and labor. However, pathologic pregnancies, including gestational diabetes mellitus (GDM), are associated with a heightened level of oxidative stress, owing to both overproduction of free radicals and/or a defect in the antioxidant defenses. This has important implications on the mother, placental function, and fetal well-being. Animal models of diabetes have confirmed the important role of oxidative stress in the etiology of congenital malformations; the relative immaturity of the antioxidant system facilitates the exposure of embryos and fetuses to the damaging effects of oxidative stress. Of note, there are only a few clinical studies evaluating the potential beneficial effects of antioxidants in GDM. Thus, whether or not increased antioxidant intake can reduce the complications of GDM in both mother and fetus needs to be explored. This review provides an overview and updated data on our current understanding of the complications associated with oxidative changes in GDM.Fil: Lappas, Martha. The University of Melbourne; AustraliaFil: Hiden, Ursula. University of Graz; AustriaFil: Desoye, Gernot. University of Graz; AustriaFil: Froehlich, Julia. University of Graz; AustriaFil: Hauguel de Mouzon, Sylvie. Case Western Reserve University; Estados UnidosFil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaMary Ann Liebert Inc2011-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17444Lappas, Martha; Hiden, Ursula; Desoye, Gernot; Froehlich, Julia; Hauguel de Mouzon, Sylvie; et al.; The role of oxidative stress in the pathophysiology of gestational diabetes mellitus; Mary Ann Liebert Inc; Antioxidants & Redox Signaling; 15; 12; 10-2011; 3061-31001523-0864enginfo:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/ars.2010.3765info:eu-repo/semantics/altIdentifier/doi/10.1089/ars.2010.3765info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:19Zoai:ri.conicet.gov.ar:11336/17444instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:19.385CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
title The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
spellingShingle The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
Lappas, Martha
Diabetes
Pregnancy
Oxidative Stress
Placenta
title_short The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
title_full The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
title_fullStr The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
title_full_unstemmed The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
title_sort The role of oxidative stress in the pathophysiology of gestational diabetes mellitus
dc.creator.none.fl_str_mv Lappas, Martha
Hiden, Ursula
Desoye, Gernot
Froehlich, Julia
Hauguel de Mouzon, Sylvie
Jawerbaum, Alicia Sandra
author Lappas, Martha
author_facet Lappas, Martha
Hiden, Ursula
Desoye, Gernot
Froehlich, Julia
Hauguel de Mouzon, Sylvie
Jawerbaum, Alicia Sandra
author_role author
author2 Hiden, Ursula
Desoye, Gernot
Froehlich, Julia
Hauguel de Mouzon, Sylvie
Jawerbaum, Alicia Sandra
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Diabetes
Pregnancy
Oxidative Stress
Placenta
topic Diabetes
Pregnancy
Oxidative Stress
Placenta
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy, it plays important roles in embryo development, implantation, placental development and function, fetal development, and labor. However, pathologic pregnancies, including gestational diabetes mellitus (GDM), are associated with a heightened level of oxidative stress, owing to both overproduction of free radicals and/or a defect in the antioxidant defenses. This has important implications on the mother, placental function, and fetal well-being. Animal models of diabetes have confirmed the important role of oxidative stress in the etiology of congenital malformations; the relative immaturity of the antioxidant system facilitates the exposure of embryos and fetuses to the damaging effects of oxidative stress. Of note, there are only a few clinical studies evaluating the potential beneficial effects of antioxidants in GDM. Thus, whether or not increased antioxidant intake can reduce the complications of GDM in both mother and fetus needs to be explored. This review provides an overview and updated data on our current understanding of the complications associated with oxidative changes in GDM.
Fil: Lappas, Martha. The University of Melbourne; Australia
Fil: Hiden, Ursula. University of Graz; Austria
Fil: Desoye, Gernot. University of Graz; Austria
Fil: Froehlich, Julia. University of Graz; Austria
Fil: Hauguel de Mouzon, Sylvie. Case Western Reserve University; Estados Unidos
Fil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy, it plays important roles in embryo development, implantation, placental development and function, fetal development, and labor. However, pathologic pregnancies, including gestational diabetes mellitus (GDM), are associated with a heightened level of oxidative stress, owing to both overproduction of free radicals and/or a defect in the antioxidant defenses. This has important implications on the mother, placental function, and fetal well-being. Animal models of diabetes have confirmed the important role of oxidative stress in the etiology of congenital malformations; the relative immaturity of the antioxidant system facilitates the exposure of embryos and fetuses to the damaging effects of oxidative stress. Of note, there are only a few clinical studies evaluating the potential beneficial effects of antioxidants in GDM. Thus, whether or not increased antioxidant intake can reduce the complications of GDM in both mother and fetus needs to be explored. This review provides an overview and updated data on our current understanding of the complications associated with oxidative changes in GDM.
publishDate 2011
dc.date.none.fl_str_mv 2011-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17444
Lappas, Martha; Hiden, Ursula; Desoye, Gernot; Froehlich, Julia; Hauguel de Mouzon, Sylvie; et al.; The role of oxidative stress in the pathophysiology of gestational diabetes mellitus; Mary Ann Liebert Inc; Antioxidants & Redox Signaling; 15; 12; 10-2011; 3061-3100
1523-0864
url http://hdl.handle.net/11336/17444
identifier_str_mv Lappas, Martha; Hiden, Ursula; Desoye, Gernot; Froehlich, Julia; Hauguel de Mouzon, Sylvie; et al.; The role of oxidative stress in the pathophysiology of gestational diabetes mellitus; Mary Ann Liebert Inc; Antioxidants & Redox Signaling; 15; 12; 10-2011; 3061-3100
1523-0864
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/ars.2010.3765
info:eu-repo/semantics/altIdentifier/doi/10.1089/ars.2010.3765
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert Inc
publisher.none.fl_str_mv Mary Ann Liebert Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269087437160448
score 13.13397

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