Evidence of two co-circulating genetic lineages of canine distemper virus in South America

Autores
Panzera, Yanina; Gallo Calderon, Marina Beatriz; Sarute, Nicolás; Guasco, Soledad; Cardeillac, Arianne; Bonilla, Braulio; Hernández, Martín; Francia, Lourdes; Bedó, Gabriela; la Torre, Jose Leonardo; Pérez, Ruben
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Canine distemper virus (CDV) is the etiological agent of a multisystemic infection that affects different species of carnivores and is responsible for one of the main diseases suffered by dogs. Recent data have shown a worldwide increase in the incidence of the disease, including in vaccinated dog populations, which necessitates the analysis of circulating strains. The hemagglutinin (H) gene, which encodes the major antigenic viral protein, has been widely used to determine the degree of genetic variability and to associate CDVs in different worldwide circulating lineages. Here, we obtained the sequence of the first full-length H gene of field South American CDV strains and compared it with sequences of worldwide circulating field strains and vaccine viruses. In South America, we detect two co-circulating lineages with different prevalences: the Europe 1 lineage and a new South America 2 lineage. The Europe 1 lineage was the most prevalent in South America, and we suggest renaming it the Europe 1/South America 1 lineage. The South America 2 lineage was found only in Argentina and appears related to wild CDV strains. All South American CDV strains showed high amino-acid divergence from vaccine strains. This genetic variability may be a possible factor leading to the resurgence of distemper cases in vaccinated dog populations.
Fil: Panzera, Yanina. Universidad de la República; Uruguay
Fil: Gallo Calderon, Marina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. Cesar Milstein". Fundación Pablo Cassara. Instituto de Ciencia y Tecnología ; Argentina
Fil: Sarute, Nicolás. Universidad de la República; Uruguay
Fil: Guasco, Soledad. Universidad de la República; Uruguay
Fil: Cardeillac, Arianne. Universidad de la República; Uruguay
Fil: Bonilla, Braulio. Universidad de la República; Uruguay
Fil: Hernández, Martín. Universidad de la República; Uruguay
Fil: Francia, Lourdes. Universidad de la República; Uruguay
Fil: Bedó, Gabriela. Universidad de la República; Uruguay
Fil: la Torre, Jose Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. Cesar Milstein". Fundación Pablo Cassara. Instituto de Ciencia y Tecnología ; Argentina
Fil: Pérez, Ruben. Universidad de la República; Uruguay
Materia
Canine Distemper Virus
H Gene
South America Lineage
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16894
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/16894
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evidence of two co-circulating genetic lineages of canine distemper virus in South AmericaPanzera, YaninaGallo Calderon, Marina BeatrizSarute, NicolásGuasco, SoledadCardeillac, ArianneBonilla, BraulioHernández, MartínFrancia, LourdesBedó, Gabrielala Torre, Jose LeonardoPérez, RubenCanine Distemper VirusH GeneSouth America Lineagehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Canine distemper virus (CDV) is the etiological agent of a multisystemic infection that affects different species of carnivores and is responsible for one of the main diseases suffered by dogs. Recent data have shown a worldwide increase in the incidence of the disease, including in vaccinated dog populations, which necessitates the analysis of circulating strains. The hemagglutinin (H) gene, which encodes the major antigenic viral protein, has been widely used to determine the degree of genetic variability and to associate CDVs in different worldwide circulating lineages. Here, we obtained the sequence of the first full-length H gene of field South American CDV strains and compared it with sequences of worldwide circulating field strains and vaccine viruses. In South America, we detect two co-circulating lineages with different prevalences: the Europe 1 lineage and a new South America 2 lineage. The Europe 1 lineage was the most prevalent in South America, and we suggest renaming it the Europe 1/South America 1 lineage. The South America 2 lineage was found only in Argentina and appears related to wild CDV strains. All South American CDV strains showed high amino-acid divergence from vaccine strains. This genetic variability may be a possible factor leading to the resurgence of distemper cases in vaccinated dog populations.Fil: Panzera, Yanina. Universidad de la República; UruguayFil: Gallo Calderon, Marina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. Cesar Milstein". Fundación Pablo Cassara. Instituto de Ciencia y Tecnología ; ArgentinaFil: Sarute, Nicolás. Universidad de la República; UruguayFil: Guasco, Soledad. Universidad de la República; UruguayFil: Cardeillac, Arianne. Universidad de la República; UruguayFil: Bonilla, Braulio. Universidad de la República; UruguayFil: Hernández, Martín. Universidad de la República; UruguayFil: Francia, Lourdes. Universidad de la República; UruguayFil: Bedó, Gabriela. Universidad de la República; UruguayFil: la Torre, Jose Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. Cesar Milstein". Fundación Pablo Cassara. Instituto de Ciencia y Tecnología ; ArgentinaFil: Pérez, Ruben. Universidad de la República; UruguayElsevier Science2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16894Panzera, Yanina; Gallo Calderon, Marina Beatriz; Sarute, Nicolás; Guasco, Soledad; Cardeillac, Arianne; et al.; Evidence of two co-circulating genetic lineages of canine distemper virus in South America; Elsevier Science; Virus Research; 163; 1; 1-2012; 401-4040168-1702enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.virusres.2011.10.008info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0168170211004023info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:35Zoai:ri.conicet.gov.ar:11336/16894instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:35.558CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evidence of two co-circulating genetic lineages of canine distemper virus in South America
title Evidence of two co-circulating genetic lineages of canine distemper virus in South America
spellingShingle Evidence of two co-circulating genetic lineages of canine distemper virus in South America
Panzera, Yanina
Canine Distemper Virus
H Gene
South America Lineage
title_short Evidence of two co-circulating genetic lineages of canine distemper virus in South America
title_full Evidence of two co-circulating genetic lineages of canine distemper virus in South America
title_fullStr Evidence of two co-circulating genetic lineages of canine distemper virus in South America
title_full_unstemmed Evidence of two co-circulating genetic lineages of canine distemper virus in South America
title_sort Evidence of two co-circulating genetic lineages of canine distemper virus in South America
dc.creator.none.fl_str_mv Panzera, Yanina
Gallo Calderon, Marina Beatriz
Sarute, Nicolás
Guasco, Soledad
Cardeillac, Arianne
Bonilla, Braulio
Hernández, Martín
Francia, Lourdes
Bedó, Gabriela
la Torre, Jose Leonardo
Pérez, Ruben
author Panzera, Yanina
author_facet Panzera, Yanina
Gallo Calderon, Marina Beatriz
Sarute, Nicolás
Guasco, Soledad
Cardeillac, Arianne
Bonilla, Braulio
Hernández, Martín
Francia, Lourdes
Bedó, Gabriela
la Torre, Jose Leonardo
Pérez, Ruben
author_role author
author2 Gallo Calderon, Marina Beatriz
Sarute, Nicolás
Guasco, Soledad
Cardeillac, Arianne
Bonilla, Braulio
Hernández, Martín
Francia, Lourdes
Bedó, Gabriela
la Torre, Jose Leonardo
Pérez, Ruben
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Canine Distemper Virus
H Gene
South America Lineage
topic Canine Distemper Virus
H Gene
South America Lineage
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Canine distemper virus (CDV) is the etiological agent of a multisystemic infection that affects different species of carnivores and is responsible for one of the main diseases suffered by dogs. Recent data have shown a worldwide increase in the incidence of the disease, including in vaccinated dog populations, which necessitates the analysis of circulating strains. The hemagglutinin (H) gene, which encodes the major antigenic viral protein, has been widely used to determine the degree of genetic variability and to associate CDVs in different worldwide circulating lineages. Here, we obtained the sequence of the first full-length H gene of field South American CDV strains and compared it with sequences of worldwide circulating field strains and vaccine viruses. In South America, we detect two co-circulating lineages with different prevalences: the Europe 1 lineage and a new South America 2 lineage. The Europe 1 lineage was the most prevalent in South America, and we suggest renaming it the Europe 1/South America 1 lineage. The South America 2 lineage was found only in Argentina and appears related to wild CDV strains. All South American CDV strains showed high amino-acid divergence from vaccine strains. This genetic variability may be a possible factor leading to the resurgence of distemper cases in vaccinated dog populations.
Fil: Panzera, Yanina. Universidad de la República; Uruguay
Fil: Gallo Calderon, Marina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. Cesar Milstein". Fundación Pablo Cassara. Instituto de Ciencia y Tecnología ; Argentina
Fil: Sarute, Nicolás. Universidad de la República; Uruguay
Fil: Guasco, Soledad. Universidad de la República; Uruguay
Fil: Cardeillac, Arianne. Universidad de la República; Uruguay
Fil: Bonilla, Braulio. Universidad de la República; Uruguay
Fil: Hernández, Martín. Universidad de la República; Uruguay
Fil: Francia, Lourdes. Universidad de la República; Uruguay
Fil: Bedó, Gabriela. Universidad de la República; Uruguay
Fil: la Torre, Jose Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. Cesar Milstein". Fundación Pablo Cassara. Instituto de Ciencia y Tecnología ; Argentina
Fil: Pérez, Ruben. Universidad de la República; Uruguay
description Canine distemper virus (CDV) is the etiological agent of a multisystemic infection that affects different species of carnivores and is responsible for one of the main diseases suffered by dogs. Recent data have shown a worldwide increase in the incidence of the disease, including in vaccinated dog populations, which necessitates the analysis of circulating strains. The hemagglutinin (H) gene, which encodes the major antigenic viral protein, has been widely used to determine the degree of genetic variability and to associate CDVs in different worldwide circulating lineages. Here, we obtained the sequence of the first full-length H gene of field South American CDV strains and compared it with sequences of worldwide circulating field strains and vaccine viruses. In South America, we detect two co-circulating lineages with different prevalences: the Europe 1 lineage and a new South America 2 lineage. The Europe 1 lineage was the most prevalent in South America, and we suggest renaming it the Europe 1/South America 1 lineage. The South America 2 lineage was found only in Argentina and appears related to wild CDV strains. All South American CDV strains showed high amino-acid divergence from vaccine strains. This genetic variability may be a possible factor leading to the resurgence of distemper cases in vaccinated dog populations.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16894
Panzera, Yanina; Gallo Calderon, Marina Beatriz; Sarute, Nicolás; Guasco, Soledad; Cardeillac, Arianne; et al.; Evidence of two co-circulating genetic lineages of canine distemper virus in South America; Elsevier Science; Virus Research; 163; 1; 1-2012; 401-404
0168-1702
url http://hdl.handle.net/11336/16894
identifier_str_mv Panzera, Yanina; Gallo Calderon, Marina Beatriz; Sarute, Nicolás; Guasco, Soledad; Cardeillac, Arianne; et al.; Evidence of two co-circulating genetic lineages of canine distemper virus in South America; Elsevier Science; Virus Research; 163; 1; 1-2012; 401-404
0168-1702
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virusres.2011.10.008
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0168170211004023
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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