Hybrid compounds as anti-infective agents

Autores
Sbaraglini, Maria Laura; Talevi, Alan
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance linked to single gene product. Although less frequently explored, they could also be useful in the treatment of frequently occurring co-infections. Here, we overview recent advances in the field of hybrid antimicrobials. Furthermore, we discuss some cutting-edge approaches to face the development of designed multi-target agents in the era of omics and big data, namely analysis of gene signatures and multitask QSAR models.
Fil: Sbaraglini, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina
Fil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina
Materia
Anti-Infective
Antibiotic
Antifungal
Antimicrobial
Antimicrobial Resistance
Antiviral
Chimeric Molecule
Hybrid Drug
Hybrid Molecule
Multi-Target Agents
Multi-Target Drug
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55197
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/55197
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hybrid compounds as anti-infective agentsSbaraglini, Maria LauraTalevi, AlanAnti-InfectiveAntibioticAntifungalAntimicrobialAntimicrobial ResistanceAntiviralChimeric MoleculeHybrid DrugHybrid MoleculeMulti-Target AgentsMulti-Target Drughttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance linked to single gene product. Although less frequently explored, they could also be useful in the treatment of frequently occurring co-infections. Here, we overview recent advances in the field of hybrid antimicrobials. Furthermore, we discuss some cutting-edge approaches to face the development of designed multi-target agents in the era of omics and big data, namely analysis of gene signatures and multitask QSAR models.Fil: Sbaraglini, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; ArgentinaFil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; ArgentinaBentham Science Publishers2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55197Sbaraglini, Maria Laura; Talevi, Alan; Hybrid compounds as anti-infective agents; Bentham Science Publishers; Current Topics in Medicinal Chemistry; 17; 9; 4-2017; 1080-10951568-02661873-4294CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1568026616666160927160912info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/145866/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:01Zoai:ri.conicet.gov.ar:11336/55197instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:01.347CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hybrid compounds as anti-infective agents
title Hybrid compounds as anti-infective agents
spellingShingle Hybrid compounds as anti-infective agents
Sbaraglini, Maria Laura
Anti-Infective
Antibiotic
Antifungal
Antimicrobial
Antimicrobial Resistance
Antiviral
Chimeric Molecule
Hybrid Drug
Hybrid Molecule
Multi-Target Agents
Multi-Target Drug
title_short Hybrid compounds as anti-infective agents
title_full Hybrid compounds as anti-infective agents
title_fullStr Hybrid compounds as anti-infective agents
title_full_unstemmed Hybrid compounds as anti-infective agents
title_sort Hybrid compounds as anti-infective agents
dc.creator.none.fl_str_mv Sbaraglini, Maria Laura
Talevi, Alan
author Sbaraglini, Maria Laura
author_facet Sbaraglini, Maria Laura
Talevi, Alan
author_role author
author2 Talevi, Alan
author2_role author
dc.subject.none.fl_str_mv Anti-Infective
Antibiotic
Antifungal
Antimicrobial
Antimicrobial Resistance
Antiviral
Chimeric Molecule
Hybrid Drug
Hybrid Molecule
Multi-Target Agents
Multi-Target Drug
topic Anti-Infective
Antibiotic
Antifungal
Antimicrobial
Antimicrobial Resistance
Antiviral
Chimeric Molecule
Hybrid Drug
Hybrid Molecule
Multi-Target Agents
Multi-Target Drug
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance linked to single gene product. Although less frequently explored, they could also be useful in the treatment of frequently occurring co-infections. Here, we overview recent advances in the field of hybrid antimicrobials. Furthermore, we discuss some cutting-edge approaches to face the development of designed multi-target agents in the era of omics and big data, namely analysis of gene signatures and multitask QSAR models.
Fil: Sbaraglini, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina
Fil: Talevi, Alan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina
description Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance linked to single gene product. Although less frequently explored, they could also be useful in the treatment of frequently occurring co-infections. Here, we overview recent advances in the field of hybrid antimicrobials. Furthermore, we discuss some cutting-edge approaches to face the development of designed multi-target agents in the era of omics and big data, namely analysis of gene signatures and multitask QSAR models.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55197
Sbaraglini, Maria Laura; Talevi, Alan; Hybrid compounds as anti-infective agents; Bentham Science Publishers; Current Topics in Medicinal Chemistry; 17; 9; 4-2017; 1080-1095
1568-0266
1873-4294
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55197
identifier_str_mv Sbaraglini, Maria Laura; Talevi, Alan; Hybrid compounds as anti-infective agents; Bentham Science Publishers; Current Topics in Medicinal Chemistry; 17; 9; 4-2017; 1080-1095
1568-0266
1873-4294
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/1568026616666160927160912
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/145866/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268831459835904
score 13.13397

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