Tailored Multi-Target Agents: Applications and Design Considerations

Autores
Talevi, Alan
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in fact unintended multi-functional therapeutics that have emerged from phenotypic models. The last two decades, however, have witnessed the emergence of tailored multi-target agents, which according to our perspective combine the best aspects of target-based and phenotypic-based drug discovery. Here we discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with neglected advantages that this type of agents might have in clinical trials.
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Tailored Multi-Target Agents
Virtual Screening
Drug Design
In Silico Screening
Binding Efficiency Metrics
Drug Resistance
Network Pharmacology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/54278
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/54278
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network_name_str CONICET Digital (CONICET)
spelling Tailored Multi-Target Agents: Applications and Design ConsiderationsTalevi, AlanTailored Multi-Target AgentsVirtual ScreeningDrug DesignIn Silico ScreeningBinding Efficiency MetricsDrug ResistanceNetwork Pharmacologyhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in fact unintended multi-functional therapeutics that have emerged from phenotypic models. The last two decades, however, have witnessed the emergence of tailored multi-target agents, which according to our perspective combine the best aspects of target-based and phenotypic-based drug discovery. Here we discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with neglected advantages that this type of agents might have in clinical trials.Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBentham Science Publishers2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/54278Talevi, Alan; Tailored Multi-Target Agents: Applications and Design Considerations; Bentham Science Publishers; Current Pharmaceutical Design; 22; 21; 3-2016; 3164-31701381-6128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ingentaconnect.com/contentone/ben/cpd/2016/00000022/00000021/art00008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:43Zoai:ri.conicet.gov.ar:11336/54278instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:43.481CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tailored Multi-Target Agents: Applications and Design Considerations
title Tailored Multi-Target Agents: Applications and Design Considerations
spellingShingle Tailored Multi-Target Agents: Applications and Design Considerations
Talevi, Alan
Tailored Multi-Target Agents
Virtual Screening
Drug Design
In Silico Screening
Binding Efficiency Metrics
Drug Resistance
Network Pharmacology
title_short Tailored Multi-Target Agents: Applications and Design Considerations
title_full Tailored Multi-Target Agents: Applications and Design Considerations
title_fullStr Tailored Multi-Target Agents: Applications and Design Considerations
title_full_unstemmed Tailored Multi-Target Agents: Applications and Design Considerations
title_sort Tailored Multi-Target Agents: Applications and Design Considerations
dc.creator.none.fl_str_mv Talevi, Alan
author Talevi, Alan
author_facet Talevi, Alan
author_role author
dc.subject.none.fl_str_mv Tailored Multi-Target Agents
Virtual Screening
Drug Design
In Silico Screening
Binding Efficiency Metrics
Drug Resistance
Network Pharmacology
topic Tailored Multi-Target Agents
Virtual Screening
Drug Design
In Silico Screening
Binding Efficiency Metrics
Drug Resistance
Network Pharmacology
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in fact unintended multi-functional therapeutics that have emerged from phenotypic models. The last two decades, however, have witnessed the emergence of tailored multi-target agents, which according to our perspective combine the best aspects of target-based and phenotypic-based drug discovery. Here we discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with neglected advantages that this type of agents might have in clinical trials.
Fil: Talevi, Alan. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in fact unintended multi-functional therapeutics that have emerged from phenotypic models. The last two decades, however, have witnessed the emergence of tailored multi-target agents, which according to our perspective combine the best aspects of target-based and phenotypic-based drug discovery. Here we discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with neglected advantages that this type of agents might have in clinical trials.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/54278
Talevi, Alan; Tailored Multi-Target Agents: Applications and Design Considerations; Bentham Science Publishers; Current Pharmaceutical Design; 22; 21; 3-2016; 3164-3170
1381-6128
CONICET Digital
CONICET
url http://hdl.handle.net/11336/54278
identifier_str_mv Talevi, Alan; Tailored Multi-Target Agents: Applications and Design Considerations; Bentham Science Publishers; Current Pharmaceutical Design; 22; 21; 3-2016; 3164-3170
1381-6128
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ingentaconnect.com/contentone/ben/cpd/2016/00000022/00000021/art00008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613615462645760
score 13.070432

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