Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review

Autores
Parisi, Mónica Graciela; Ozón, Brenda; Vera González, Sofía Macarena; García Pardo, Javier; Obregon, Walter David
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant’s defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broadspectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents.
Fil: Parisi, Mónica Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Ozón, Brenda. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina
Fil: Vera González, Sofía Macarena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina
Fil: García Pardo, Javier. Universitat Autònoma de Barcelona; España
Fil: Obregon, Walter David. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
PLANT PROTEASE INHIBITORS
ANTIBACTERIAL COMPOUNDS
ANTIMICROBIAL ACTIVITY
ANTIMICROBIAL PEPTIDES
ANTIBIOTIC RESISTANCE
ANTIFUNGAL AGENTS
CYSTEINE-RICH PEPTIDES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/237335
Acceder
id CONICETDig_59902b64ceab46848e786c2ce90c3767
oai_identifier_str oai:ri.conicet.gov.ar:11336/237335
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive ReviewParisi, Mónica GracielaOzón, BrendaVera González, Sofía MacarenaGarcía Pardo, JavierObregon, Walter DavidPLANT PROTEASE INHIBITORSANTIBACTERIAL COMPOUNDSANTIMICROBIAL ACTIVITYANTIMICROBIAL PEPTIDESANTIBIOTIC RESISTANCEANTIFUNGAL AGENTSCYSTEINE-RICH PEPTIDEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant’s defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broadspectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents.Fil: Parisi, Mónica Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Ozón, Brenda. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; ArgentinaFil: Vera González, Sofía Macarena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; ArgentinaFil: García Pardo, Javier. Universitat Autònoma de Barcelona; EspañaFil: Obregon, Walter David. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaMultidisciplinary Digital Publishing Institute2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/237335Parisi, Mónica Graciela; Ozón, Brenda; Vera González, Sofía Macarena; García Pardo, Javier; Obregon, Walter David; Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 16; 5; 4-2024; 1-151999-4923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics16050582info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/16/5/582info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:27Zoai:ri.conicet.gov.ar:11336/237335instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:27.59CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
title Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
spellingShingle Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
Parisi, Mónica Graciela
PLANT PROTEASE INHIBITORS
ANTIBACTERIAL COMPOUNDS
ANTIMICROBIAL ACTIVITY
ANTIMICROBIAL PEPTIDES
ANTIBIOTIC RESISTANCE
ANTIFUNGAL AGENTS
CYSTEINE-RICH PEPTIDES
title_short Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
title_full Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
title_fullStr Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
title_full_unstemmed Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
title_sort Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review
dc.creator.none.fl_str_mv Parisi, Mónica Graciela
Ozón, Brenda
Vera González, Sofía Macarena
García Pardo, Javier
Obregon, Walter David
author Parisi, Mónica Graciela
author_facet Parisi, Mónica Graciela
Ozón, Brenda
Vera González, Sofía Macarena
García Pardo, Javier
Obregon, Walter David
author_role author
author2 Ozón, Brenda
Vera González, Sofía Macarena
García Pardo, Javier
Obregon, Walter David
author2_role author
author
author
author
dc.subject.none.fl_str_mv PLANT PROTEASE INHIBITORS
ANTIBACTERIAL COMPOUNDS
ANTIMICROBIAL ACTIVITY
ANTIMICROBIAL PEPTIDES
ANTIBIOTIC RESISTANCE
ANTIFUNGAL AGENTS
CYSTEINE-RICH PEPTIDES
topic PLANT PROTEASE INHIBITORS
ANTIBACTERIAL COMPOUNDS
ANTIMICROBIAL ACTIVITY
ANTIMICROBIAL PEPTIDES
ANTIBIOTIC RESISTANCE
ANTIFUNGAL AGENTS
CYSTEINE-RICH PEPTIDES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant’s defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broadspectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents.
Fil: Parisi, Mónica Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Ozón, Brenda. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina
Fil: Vera González, Sofía Macarena. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina
Fil: García Pardo, Javier. Universitat Autònoma de Barcelona; España
Fil: Obregon, Walter David. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant’s defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broadspectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/237335
Parisi, Mónica Graciela; Ozón, Brenda; Vera González, Sofía Macarena; García Pardo, Javier; Obregon, Walter David; Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 16; 5; 4-2024; 1-15
1999-4923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/237335
identifier_str_mv Parisi, Mónica Graciela; Ozón, Brenda; Vera González, Sofía Macarena; García Pardo, Javier; Obregon, Walter David; Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 16; 5; 4-2024; 1-15
1999-4923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics16050582
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/16/5/582
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269855415271424
score 13.13397

Publicaciones similares