Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective
- Autores
- Talevi, Alan
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning to treat comorbid conditions is an additional, overlooked application of multi-target ligands. While medicinal chemists usually rely on some version of the lock and key paradigm to design novel therapeutics, modern pharmacology recognizes that the mid- and long-term effects of a given drug on a biological system may depend not only on the specific ligand-target recognition events but also on the influence of the repeated administration of a drug on the cell gene signature. The design of multi-target agents usually imposes challenging restrictions on the topology or flexibility of the candidate drugs, which are briefly discussed in the present article. Finally, computational strategies to approach the identification of novel multi-target agents are overviewed.
Facultad de Ciencias Exactas - Materia
-
Ciencias Exactas
Designed multiple ligands
Drug design
Drug repositioning
Drug resistance
Gene profile
Lock and key paradigm
Multi-target agents - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/85738
Ver los metadatos del registro completo
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Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspectiveTalevi, AlanCiencias ExactasDesigned multiple ligandsDrug designDrug repositioningDrug resistanceGene profileLock and key paradigmMulti-target agentsMulti-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning to treat comorbid conditions is an additional, overlooked application of multi-target ligands. While medicinal chemists usually rely on some version of the lock and key paradigm to design novel therapeutics, modern pharmacology recognizes that the mid- and long-term effects of a given drug on a biological system may depend not only on the specific ligand-target recognition events but also on the influence of the repeated administration of a drug on the cell gene signature. The design of multi-target agents usually imposes challenging restrictions on the topology or flexibility of the candidate drugs, which are briefly discussed in the present article. Finally, computational strategies to approach the identification of novel multi-target agents are overviewed.Facultad de Ciencias Exactas2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/85738enginfo:eu-repo/semantics/altIdentifier/issn/1663-9812info:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2015.00205info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:49:13Zoai:sedici.unlp.edu.ar:10915/85738Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:49:13.829SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective |
| title |
Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective |
| spellingShingle |
Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective Talevi, Alan Ciencias Exactas Designed multiple ligands Drug design Drug repositioning Drug resistance Gene profile Lock and key paradigm Multi-target agents |
| title_short |
Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective |
| title_full |
Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective |
| title_fullStr |
Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective |
| title_full_unstemmed |
Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective |
| title_sort |
Multi-target pharmacology: possibilities and limitations of the "skeleton key approach" from a medicinal chemist perspective |
| dc.creator.none.fl_str_mv |
Talevi, Alan |
| author |
Talevi, Alan |
| author_facet |
Talevi, Alan |
| author_role |
author |
| dc.subject.none.fl_str_mv |
Ciencias Exactas Designed multiple ligands Drug design Drug repositioning Drug resistance Gene profile Lock and key paradigm Multi-target agents |
| topic |
Ciencias Exactas Designed multiple ligands Drug design Drug repositioning Drug resistance Gene profile Lock and key paradigm Multi-target agents |
| dc.description.none.fl_txt_mv |
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning to treat comorbid conditions is an additional, overlooked application of multi-target ligands. While medicinal chemists usually rely on some version of the lock and key paradigm to design novel therapeutics, modern pharmacology recognizes that the mid- and long-term effects of a given drug on a biological system may depend not only on the specific ligand-target recognition events but also on the influence of the repeated administration of a drug on the cell gene signature. The design of multi-target agents usually imposes challenging restrictions on the topology or flexibility of the candidate drugs, which are briefly discussed in the present article. Finally, computational strategies to approach the identification of novel multi-target agents are overviewed. Facultad de Ciencias Exactas |
| description |
Multi-target drugs have raised considerable interest in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance issues. Prospective drug repositioning to treat comorbid conditions is an additional, overlooked application of multi-target ligands. While medicinal chemists usually rely on some version of the lock and key paradigm to design novel therapeutics, modern pharmacology recognizes that the mid- and long-term effects of a given drug on a biological system may depend not only on the specific ligand-target recognition events but also on the influence of the repeated administration of a drug on the cell gene signature. The design of multi-target agents usually imposes challenging restrictions on the topology or flexibility of the candidate drugs, which are briefly discussed in the present article. Finally, computational strategies to approach the identification of novel multi-target agents are overviewed. |
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2015 |
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2015 |
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