Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation

Autores
Bermudez, Jose Maria; Grau, Ricardo Jose Antonio
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use.
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina. Universidad Nacional de Salta; Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Materia
Drug Delivery
In Situ Forming Gel
Injectable Depot
Poloxamer
Veterinary Use
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14288

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spelling Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluationBermudez, Jose MariaGrau, Ricardo Jose AntonioDrug DeliveryIn Situ Forming GelInjectable DepotPoloxamerVeterinary Usehttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use.Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina. Universidad Nacional de Salta; ArgentinaFil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaInternational Research Journals Publishing House2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14288Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation; International Research Journals Publishing House; International Research Journal of Pharmacy and Pharmacology; 1; 6; 9-2011; 109-1182251-0176enginfo:eu-repo/semantics/altIdentifier/url/http://www.interesjournals.org/irjpp/september-2011-vol-1-issue-6/thermosensitive-poloxamer-based-injectables-as-controlled-drug-release-platformsfor-veterinary-use-development-and-in-vitro-evaluationinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:43:29Zoai:ri.conicet.gov.ar:11336/14288instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:43:29.972CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
title Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
spellingShingle Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
Bermudez, Jose Maria
Drug Delivery
In Situ Forming Gel
Injectable Depot
Poloxamer
Veterinary Use
title_short Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
title_full Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
title_fullStr Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
title_full_unstemmed Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
title_sort Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
dc.creator.none.fl_str_mv Bermudez, Jose Maria
Grau, Ricardo Jose Antonio
author Bermudez, Jose Maria
author_facet Bermudez, Jose Maria
Grau, Ricardo Jose Antonio
author_role author
author2 Grau, Ricardo Jose Antonio
author2_role author
dc.subject.none.fl_str_mv Drug Delivery
In Situ Forming Gel
Injectable Depot
Poloxamer
Veterinary Use
topic Drug Delivery
In Situ Forming Gel
Injectable Depot
Poloxamer
Veterinary Use
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use.
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina. Universidad Nacional de Salta; Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
description The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14288
Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation; International Research Journals Publishing House; International Research Journal of Pharmacy and Pharmacology; 1; 6; 9-2011; 109-118
2251-0176
url http://hdl.handle.net/11336/14288
identifier_str_mv Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation; International Research Journals Publishing House; International Research Journal of Pharmacy and Pharmacology; 1; 6; 9-2011; 109-118
2251-0176
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.interesjournals.org/irjpp/september-2011-vol-1-issue-6/thermosensitive-poloxamer-based-injectables-as-controlled-drug-release-platformsfor-veterinary-use-development-and-in-vitro-evaluation
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Research Journals Publishing House
publisher.none.fl_str_mv International Research Journals Publishing House
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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