Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation
- Autores
- Bermudez, Jose Maria; Grau, Ricardo Jose Antonio
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use.
Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina. Universidad Nacional de Salta; Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina - Materia
-
Drug Delivery
In Situ Forming Gel
Injectable Depot
Poloxamer
Veterinary Use - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/14288
Ver los metadatos del registro completo
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Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluationBermudez, Jose MariaGrau, Ricardo Jose AntonioDrug DeliveryIn Situ Forming GelInjectable DepotPoloxamerVeterinary Usehttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use.Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina. Universidad Nacional de Salta; ArgentinaFil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; ArgentinaInternational Research Journals Publishing House2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14288Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation; International Research Journals Publishing House; International Research Journal of Pharmacy and Pharmacology; 1; 6; 9-2011; 109-1182251-0176enginfo:eu-repo/semantics/altIdentifier/url/http://www.interesjournals.org/irjpp/september-2011-vol-1-issue-6/thermosensitive-poloxamer-based-injectables-as-controlled-drug-release-platformsfor-veterinary-use-development-and-in-vitro-evaluationinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:43:29Zoai:ri.conicet.gov.ar:11336/14288instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:43:29.972CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation |
title |
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation |
spellingShingle |
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation Bermudez, Jose Maria Drug Delivery In Situ Forming Gel Injectable Depot Poloxamer Veterinary Use |
title_short |
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation |
title_full |
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation |
title_fullStr |
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation |
title_full_unstemmed |
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation |
title_sort |
Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation |
dc.creator.none.fl_str_mv |
Bermudez, Jose Maria Grau, Ricardo Jose Antonio |
author |
Bermudez, Jose Maria |
author_facet |
Bermudez, Jose Maria Grau, Ricardo Jose Antonio |
author_role |
author |
author2 |
Grau, Ricardo Jose Antonio |
author2_role |
author |
dc.subject.none.fl_str_mv |
Drug Delivery In Situ Forming Gel Injectable Depot Poloxamer Veterinary Use |
topic |
Drug Delivery In Situ Forming Gel Injectable Depot Poloxamer Veterinary Use |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.5 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use. Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Investigación Para la Industria Química (i); Argentina. Universidad Nacional de Salta; Argentina Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina |
description |
The aim of this work was to explore the potential of combining two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride for their utilization in the design of thermosensitive injectable depot systems for drug release. These delivery platforms were designed by combination of two different poloxamers (P407 and P188) with κ-carrageenan and sodium chloride. The addition of 10-15% w/w P188 in the poloxamer solution containing 28% w/w P407 allowed optimal gelation temperatures (24-28 °C) and a quick gelation process (30 s). The addition of 0.1% w/w of κ- carrageenan increased 3-fold the gel strength and did not change gelation temperature, compared with P407/P188 (28/15% w/w) alone. On the other hand, sodium chloride increased the gel strength and decreased the gelation temperature as a function of its concentration. In in-vitro release experiments, κ-carrageenan decreased the release rate of progesterone and reduced significantly the gel erosion in 48 h. This study demonstrates that addition of κ-carrageenan and sodium chloride into poloxamers blends can be considered a useful tool to design thermosensitive platforms, if added in suitable amounts. In conclusion, this system offers a promising alternative to development of injectable depot controlled drug release platforms for veterinary use. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/14288 Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation; International Research Journals Publishing House; International Research Journal of Pharmacy and Pharmacology; 1; 6; 9-2011; 109-118 2251-0176 |
url |
http://hdl.handle.net/11336/14288 |
identifier_str_mv |
Bermudez, Jose Maria; Grau, Ricardo Jose Antonio; Thermosensitive poloxamer-based injectables as controlled drug release platforms for veterinary use: development and in-vitro evaluation; International Research Journals Publishing House; International Research Journal of Pharmacy and Pharmacology; 1; 6; 9-2011; 109-118 2251-0176 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.interesjournals.org/irjpp/september-2011-vol-1-issue-6/thermosensitive-poloxamer-based-injectables-as-controlled-drug-release-platformsfor-veterinary-use-development-and-in-vitro-evaluation |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
International Research Journals Publishing House |
publisher.none.fl_str_mv |
International Research Journals Publishing House |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846083540106608640 |
score |
13.22299 |