Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials

Autores
Sosnik, Alejandro Dario; Cohn, Daniel; San Román, Julio; Abraham, Gustavo Abel
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper describes the functionalization and crosslinking of PluronicRTM derivatives in aqueous solution at 37°C. Pluronic dimethacrylate was obtained by reacting native PEO-PPO-PEO triblocks with methacryloyl chloride and then crosslinking them by free radical polymerization at 37°C, using a redox system. The resulting gel and its rheological behavior were characterized by different techniques. The swelling study of the crosslinked polymer was indicative of its reverse thermo-responsive behavior, as illustrated by the almost 800% water uptake of the polymer at 37°C, as opposed to the 1600% attained by the polymer at 25°C. As expected, while the Pluronic dimethacrylate gel displayed an Ec value of 142.5 ± 29.7 kPa at 37°C, the crosslinked system attained a Young's modulus three times higher: 415.2 ± 45.7 kPa. Finally, the environmental SEM analysis revealed the porous microstructure of the crosslinked gels.
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
Fil: Cohn, Daniel. The Hebrew University of Jerusalem; Israel
Fil: San Román, Julio. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
Crosslinking
Gels
Injectable Polymers
Peo-Ppo-Peo Triblocks
Reverse Thermal Gelation
Viscoelastic Behavior
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78684
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/78684
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materialsSosnik, Alejandro DarioCohn, DanielSan Román, JulioAbraham, Gustavo AbelCrosslinkingGelsInjectable PolymersPeo-Ppo-Peo TriblocksReverse Thermal GelationViscoelastic Behaviorhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This paper describes the functionalization and crosslinking of PluronicRTM derivatives in aqueous solution at 37°C. Pluronic dimethacrylate was obtained by reacting native PEO-PPO-PEO triblocks with methacryloyl chloride and then crosslinking them by free radical polymerization at 37°C, using a redox system. The resulting gel and its rheological behavior were characterized by different techniques. The swelling study of the crosslinked polymer was indicative of its reverse thermo-responsive behavior, as illustrated by the almost 800% water uptake of the polymer at 37°C, as opposed to the 1600% attained by the polymer at 25°C. As expected, while the Pluronic dimethacrylate gel displayed an Ec value of 142.5 ± 29.7 kPa at 37°C, the crosslinked system attained a Young's modulus three times higher: 415.2 ± 45.7 kPa. Finally, the environmental SEM analysis revealed the porous microstructure of the crosslinked gels.Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Cohn, Daniel. The Hebrew University of Jerusalem; IsraelFil: San Román, Julio. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaVsp Bv2002-04-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78684Sosnik, Alejandro Dario; Cohn, Daniel; San Román, Julio; Abraham, Gustavo Abel; Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials; Vsp Bv; Journal of Biomaterials Science - Polymer Edition; 14; 3; 2-4-2002; 227-2390920-5063CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1163/156856203763572680?journalCode=tbsp20info:eu-repo/semantics/altIdentifier/doi/10.1163/156856203763572680info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:54Zoai:ri.conicet.gov.ar:11336/78684instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:54.798CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
title Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
spellingShingle Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
Sosnik, Alejandro Dario
Crosslinking
Gels
Injectable Polymers
Peo-Ppo-Peo Triblocks
Reverse Thermal Gelation
Viscoelastic Behavior
title_short Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
title_full Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
title_fullStr Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
title_full_unstemmed Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
title_sort Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials
dc.creator.none.fl_str_mv Sosnik, Alejandro Dario
Cohn, Daniel
San Román, Julio
Abraham, Gustavo Abel
author Sosnik, Alejandro Dario
author_facet Sosnik, Alejandro Dario
Cohn, Daniel
San Román, Julio
Abraham, Gustavo Abel
author_role author
author2 Cohn, Daniel
San Román, Julio
Abraham, Gustavo Abel
author2_role author
author
author
dc.subject.none.fl_str_mv Crosslinking
Gels
Injectable Polymers
Peo-Ppo-Peo Triblocks
Reverse Thermal Gelation
Viscoelastic Behavior
topic Crosslinking
Gels
Injectable Polymers
Peo-Ppo-Peo Triblocks
Reverse Thermal Gelation
Viscoelastic Behavior
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This paper describes the functionalization and crosslinking of PluronicRTM derivatives in aqueous solution at 37°C. Pluronic dimethacrylate was obtained by reacting native PEO-PPO-PEO triblocks with methacryloyl chloride and then crosslinking them by free radical polymerization at 37°C, using a redox system. The resulting gel and its rheological behavior were characterized by different techniques. The swelling study of the crosslinked polymer was indicative of its reverse thermo-responsive behavior, as illustrated by the almost 800% water uptake of the polymer at 37°C, as opposed to the 1600% attained by the polymer at 25°C. As expected, while the Pluronic dimethacrylate gel displayed an Ec value of 142.5 ± 29.7 kPa at 37°C, the crosslinked system attained a Young's modulus three times higher: 415.2 ± 45.7 kPa. Finally, the environmental SEM analysis revealed the porous microstructure of the crosslinked gels.
Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
Fil: Cohn, Daniel. The Hebrew University of Jerusalem; Israel
Fil: San Román, Julio. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description This paper describes the functionalization and crosslinking of PluronicRTM derivatives in aqueous solution at 37°C. Pluronic dimethacrylate was obtained by reacting native PEO-PPO-PEO triblocks with methacryloyl chloride and then crosslinking them by free radical polymerization at 37°C, using a redox system. The resulting gel and its rheological behavior were characterized by different techniques. The swelling study of the crosslinked polymer was indicative of its reverse thermo-responsive behavior, as illustrated by the almost 800% water uptake of the polymer at 37°C, as opposed to the 1600% attained by the polymer at 25°C. As expected, while the Pluronic dimethacrylate gel displayed an Ec value of 142.5 ± 29.7 kPa at 37°C, the crosslinked system attained a Young's modulus three times higher: 415.2 ± 45.7 kPa. Finally, the environmental SEM analysis revealed the porous microstructure of the crosslinked gels.
publishDate 2002
dc.date.none.fl_str_mv 2002-04-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78684
Sosnik, Alejandro Dario; Cohn, Daniel; San Román, Julio; Abraham, Gustavo Abel; Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials; Vsp Bv; Journal of Biomaterials Science - Polymer Edition; 14; 3; 2-4-2002; 227-239
0920-5063
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78684
identifier_str_mv Sosnik, Alejandro Dario; Cohn, Daniel; San Román, Julio; Abraham, Gustavo Abel; Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials; Vsp Bv; Journal of Biomaterials Science - Polymer Edition; 14; 3; 2-4-2002; 227-239
0920-5063
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1163/156856203763572680?journalCode=tbsp20
info:eu-repo/semantics/altIdentifier/doi/10.1163/156856203763572680
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Vsp Bv
publisher.none.fl_str_mv Vsp Bv
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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