LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease

Autores
Roca, Valeria Ines; Puntel, Mariana
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The pathogenetic mechanisms leading to typical Parkinson's Disease (PD), the second most common human neurodegenerative disorder remains unknown. Genetic variants of Leucine-Rich Repeat Kinase 2 (LRRK-2) are associated with a significantly enhanced risk for PD. The discovery that late-onset PD could be caused by the inheritance of a mutation in the LRRK-2 gene leading to familial as well as sporadic forms of PD has provided researchers an opportunity to explore the pathophysiological events underlying this complex disease. Despite extensive research our understanding of LRRK-2 biological function and regulation remains rudimentary. In this review, we give an insight into the role of LRRK-2 in modulating inflammation in the central nervous system and we hypothesize that LRRK-2 dysfunction may favor the neurodegenerative process observed in PD.
Fil: Roca, Valeria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Puntel, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
Neuroinflammation
Parkinsons Disease
Lrrk 2
Cytoquines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18331
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's DiseaseRoca, Valeria InesPuntel, MarianaNeuroinflammationParkinsons DiseaseLrrk 2Cytoquineshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The pathogenetic mechanisms leading to typical Parkinson's Disease (PD), the second most common human neurodegenerative disorder remains unknown. Genetic variants of Leucine-Rich Repeat Kinase 2 (LRRK-2) are associated with a significantly enhanced risk for PD. The discovery that late-onset PD could be caused by the inheritance of a mutation in the LRRK-2 gene leading to familial as well as sporadic forms of PD has provided researchers an opportunity to explore the pathophysiological events underlying this complex disease. Despite extensive research our understanding of LRRK-2 biological function and regulation remains rudimentary. In this review, we give an insight into the role of LRRK-2 in modulating inflammation in the central nervous system and we hypothesize that LRRK-2 dysfunction may favor the neurodegenerative process observed in PD.Fil: Roca, Valeria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Puntel, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaIOS Press2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18331Roca, Valeria Ines; Puntel, Mariana; LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease; IOS Press; Advances in Neuroimmune Biology; 4; 3; 11-2013; 205-2151878-9498CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://content.iospress.com/articles/advances-in-neuroimmune-biology/nib130067info:eu-repo/semantics/altIdentifier/doi/10.3233/NIB-130067info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:58Zoai:ri.conicet.gov.ar:11336/18331instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:58.872CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
title LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
spellingShingle LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
Roca, Valeria Ines
Neuroinflammation
Parkinsons Disease
Lrrk 2
Cytoquines
title_short LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
title_full LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
title_fullStr LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
title_full_unstemmed LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
title_sort LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
dc.creator.none.fl_str_mv Roca, Valeria Ines
Puntel, Mariana
author Roca, Valeria Ines
author_facet Roca, Valeria Ines
Puntel, Mariana
author_role author
author2 Puntel, Mariana
author2_role author
dc.subject.none.fl_str_mv Neuroinflammation
Parkinsons Disease
Lrrk 2
Cytoquines
topic Neuroinflammation
Parkinsons Disease
Lrrk 2
Cytoquines
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The pathogenetic mechanisms leading to typical Parkinson's Disease (PD), the second most common human neurodegenerative disorder remains unknown. Genetic variants of Leucine-Rich Repeat Kinase 2 (LRRK-2) are associated with a significantly enhanced risk for PD. The discovery that late-onset PD could be caused by the inheritance of a mutation in the LRRK-2 gene leading to familial as well as sporadic forms of PD has provided researchers an opportunity to explore the pathophysiological events underlying this complex disease. Despite extensive research our understanding of LRRK-2 biological function and regulation remains rudimentary. In this review, we give an insight into the role of LRRK-2 in modulating inflammation in the central nervous system and we hypothesize that LRRK-2 dysfunction may favor the neurodegenerative process observed in PD.
Fil: Roca, Valeria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Puntel, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description The pathogenetic mechanisms leading to typical Parkinson's Disease (PD), the second most common human neurodegenerative disorder remains unknown. Genetic variants of Leucine-Rich Repeat Kinase 2 (LRRK-2) are associated with a significantly enhanced risk for PD. The discovery that late-onset PD could be caused by the inheritance of a mutation in the LRRK-2 gene leading to familial as well as sporadic forms of PD has provided researchers an opportunity to explore the pathophysiological events underlying this complex disease. Despite extensive research our understanding of LRRK-2 biological function and regulation remains rudimentary. In this review, we give an insight into the role of LRRK-2 in modulating inflammation in the central nervous system and we hypothesize that LRRK-2 dysfunction may favor the neurodegenerative process observed in PD.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18331
Roca, Valeria Ines; Puntel, Mariana; LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease; IOS Press; Advances in Neuroimmune Biology; 4; 3; 11-2013; 205-215
1878-9498
CONICET Digital
CONICET
url http://hdl.handle.net/11336/18331
identifier_str_mv Roca, Valeria Ines; Puntel, Mariana; LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease; IOS Press; Advances in Neuroimmune Biology; 4; 3; 11-2013; 205-215
1878-9498
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://content.iospress.com/articles/advances-in-neuroimmune-biology/nib130067
info:eu-repo/semantics/altIdentifier/doi/10.3233/NIB-130067
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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