Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease

Autores
Melloni, Margherita; Sedeño, Lucas; Hesse, Eugenia; García Cordero, Indira; Mikulan, Ezequiel; Plastino, Ángel Luis; Marcotti, Aida; López, José David; Bustamante, Catalina; Lopera, Francisco; Pineda, David; García, Adolfo M.; Manes, Facundo; Trujillo, Natalia; Ibáñez, Agustín
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Impairments of action language have been documented in early stage Parkinson's disease (EPD). The action-sentence compatibility effect (ACE) paradigm has revealed that EPD involves deficits to integrate action-verb processing and ongoing motor actions. Recent studies suggest that an abolished ACE in EPD reflects a cortico-subcortical disruption, and recent neurocognitive models highlight the role of the basal ganglia (BG) in motor-language coupling. Building on such breakthroughs, we report the first exploration of convergent cortical and subcortical signatures of ACE in EPD patients and matched controls. Specifically, we combined cortical recordings of the motor potential, functional connectivity measures, and structural analysis of the BG through voxel-based morphometry. Relative to controls, EPD patients exhibited an impaired ACE, a reduced motor potential, and aberrant frontotemporal connectivity. Furthermore, motor potential abnormalities during the ACE task were predicted by overall BG volume and atrophy. These results corroborate that motor-language coupling is mainly subserved by a cortico-subcortical network including the BG as a key hub. They also evince that action-verb processing may constitute a neurocognitive marker of EPD. Our findings suggest that research on the relationship between language and motor domains is crucial to develop models of motor cognition as well as diagnostic and intervention strategies.
Facultad de Ciencias Exactas
Instituto de Física La Plata
Materia
Ciencias Exactas
Ciencias Médicas
Parkinson’s disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/86715
Acceder
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network_name_str SEDICI (UNLP)
spelling Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's diseaseMelloni, MargheritaSedeño, LucasHesse, EugeniaGarcía Cordero, IndiraMikulan, EzequielPlastino, Ángel LuisMarcotti, AidaLópez, José DavidBustamante, CatalinaLopera, FranciscoPineda, DavidGarcía, Adolfo M.Manes, FacundoTrujillo, NataliaIbáñez, AgustínCiencias ExactasCiencias MédicasParkinson’s diseaseImpairments of action language have been documented in early stage Parkinson's disease (EPD). The action-sentence compatibility effect (ACE) paradigm has revealed that EPD involves deficits to integrate action-verb processing and ongoing motor actions. Recent studies suggest that an abolished ACE in EPD reflects a cortico-subcortical disruption, and recent neurocognitive models highlight the role of the basal ganglia (BG) in motor-language coupling. Building on such breakthroughs, we report the first exploration of convergent cortical and subcortical signatures of ACE in EPD patients and matched controls. Specifically, we combined cortical recordings of the motor potential, functional connectivity measures, and structural analysis of the BG through voxel-based morphometry. Relative to controls, EPD patients exhibited an impaired ACE, a reduced motor potential, and aberrant frontotemporal connectivity. Furthermore, motor potential abnormalities during the ACE task were predicted by overall BG volume and atrophy. These results corroborate that motor-language coupling is mainly subserved by a cortico-subcortical network including the BG as a key hub. They also evince that action-verb processing may constitute a neurocognitive marker of EPD. Our findings suggest that research on the relationship between language and motor domains is crucial to develop models of motor cognition as well as diagnostic and intervention strategies.Facultad de Ciencias ExactasInstituto de Física La Plata2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/86715enginfo:eu-repo/semantics/altIdentifier/issn/2045-2322info:eu-repo/semantics/altIdentifier/doi/10.1038/srep11899info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:49:12Zoai:sedici.unlp.edu.ar:10915/86715Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:49:12.887SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
title Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
spellingShingle Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
Melloni, Margherita
Ciencias Exactas
Ciencias Médicas
Parkinson’s disease
title_short Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
title_full Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
title_fullStr Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
title_full_unstemmed Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
title_sort Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
dc.creator.none.fl_str_mv Melloni, Margherita
Sedeño, Lucas
Hesse, Eugenia
García Cordero, Indira
Mikulan, Ezequiel
Plastino, Ángel Luis
Marcotti, Aida
López, José David
Bustamante, Catalina
Lopera, Francisco
Pineda, David
García, Adolfo M.
Manes, Facundo
Trujillo, Natalia
Ibáñez, Agustín
author Melloni, Margherita
author_facet Melloni, Margherita
Sedeño, Lucas
Hesse, Eugenia
García Cordero, Indira
Mikulan, Ezequiel
Plastino, Ángel Luis
Marcotti, Aida
López, José David
Bustamante, Catalina
Lopera, Francisco
Pineda, David
García, Adolfo M.
Manes, Facundo
Trujillo, Natalia
Ibáñez, Agustín
author_role author
author2 Sedeño, Lucas
Hesse, Eugenia
García Cordero, Indira
Mikulan, Ezequiel
Plastino, Ángel Luis
Marcotti, Aida
López, José David
Bustamante, Catalina
Lopera, Francisco
Pineda, David
García, Adolfo M.
Manes, Facundo
Trujillo, Natalia
Ibáñez, Agustín
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Ciencias Médicas
Parkinson’s disease
topic Ciencias Exactas
Ciencias Médicas
Parkinson’s disease
dc.description.none.fl_txt_mv Impairments of action language have been documented in early stage Parkinson's disease (EPD). The action-sentence compatibility effect (ACE) paradigm has revealed that EPD involves deficits to integrate action-verb processing and ongoing motor actions. Recent studies suggest that an abolished ACE in EPD reflects a cortico-subcortical disruption, and recent neurocognitive models highlight the role of the basal ganglia (BG) in motor-language coupling. Building on such breakthroughs, we report the first exploration of convergent cortical and subcortical signatures of ACE in EPD patients and matched controls. Specifically, we combined cortical recordings of the motor potential, functional connectivity measures, and structural analysis of the BG through voxel-based morphometry. Relative to controls, EPD patients exhibited an impaired ACE, a reduced motor potential, and aberrant frontotemporal connectivity. Furthermore, motor potential abnormalities during the ACE task were predicted by overall BG volume and atrophy. These results corroborate that motor-language coupling is mainly subserved by a cortico-subcortical network including the BG as a key hub. They also evince that action-verb processing may constitute a neurocognitive marker of EPD. Our findings suggest that research on the relationship between language and motor domains is crucial to develop models of motor cognition as well as diagnostic and intervention strategies.
Facultad de Ciencias Exactas
Instituto de Física La Plata
description Impairments of action language have been documented in early stage Parkinson's disease (EPD). The action-sentence compatibility effect (ACE) paradigm has revealed that EPD involves deficits to integrate action-verb processing and ongoing motor actions. Recent studies suggest that an abolished ACE in EPD reflects a cortico-subcortical disruption, and recent neurocognitive models highlight the role of the basal ganglia (BG) in motor-language coupling. Building on such breakthroughs, we report the first exploration of convergent cortical and subcortical signatures of ACE in EPD patients and matched controls. Specifically, we combined cortical recordings of the motor potential, functional connectivity measures, and structural analysis of the BG through voxel-based morphometry. Relative to controls, EPD patients exhibited an impaired ACE, a reduced motor potential, and aberrant frontotemporal connectivity. Furthermore, motor potential abnormalities during the ACE task were predicted by overall BG volume and atrophy. These results corroborate that motor-language coupling is mainly subserved by a cortico-subcortical network including the BG as a key hub. They also evince that action-verb processing may constitute a neurocognitive marker of EPD. Our findings suggest that research on the relationship between language and motor domains is crucial to develop models of motor cognition as well as diagnostic and intervention strategies.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/86715
url http://sedici.unlp.edu.ar/handle/10915/86715
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2045-2322
info:eu-repo/semantics/altIdentifier/doi/10.1038/srep11899
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
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instname_str Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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