Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers

Autores
García, Adolfo Martín; Sedeño, Lucas; Trujillo, Natalia; Bocanegra, Yamile; Gomez, Diana; Pineda, David; Villegas, Andrés; Muñoz, Edinson; Arias, William; Ibañez, Agustin Mariano
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. Methods: We administered executive, semantic, verb-production, and syntactic tasks to sporadic PD patients, genetic PD patients with PARK2 (parkin) or LRRK2 (dardarin) mutation, asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls. Moreover, to detect sui generis language disturbances, we ran analysis of covariance tests using executive functions as covariate. Results: The two clinical groups showed impairments in all measures, most of which survived covariation with executive functions. However, the key finding concerned asymptomatic mutation carriers. While these subjects showed intact executive, semantic, and action-verb production skills, they evinced deficits in a syntactic test with minimal working memory load. Conclusions: We propose that this sui generis disturbance may constitute a prodromal sign anticipating eventual development of PD. Moreover, our results suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms.
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Trujillo, Natalia. Universidad de Antioquia; Colombia
Fil: Bocanegra, Yamile. Universidad de Antioquia; Colombia
Fil: Gomez, Diana. Universidad de Antioquia; Colombia
Fil: Pineda, David. Universidad de Antioquia; Colombia
Fil: Villegas, Andrés. Universidad de Antioquia; Colombia
Fil: Muñoz, Edinson. Universidad de Santiago de Chile; Chile
Fil: Arias, William. Universidad de Antioquia; Colombia
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Macquarie University; Australia
Materia
Genetic Parkinson'S Disease
Language
Lrrk2
Park2
Preclinical Mutation Carriers
Sporadic Parkinson'S Disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66502

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation CarriersGarcía, Adolfo MartínSedeño, LucasTrujillo, NataliaBocanegra, YamileGomez, DianaPineda, DavidVillegas, AndrésMuñoz, EdinsonArias, WilliamIbañez, Agustin MarianoGenetic Parkinson'S DiseaseLanguageLrrk2Park2Preclinical Mutation CarriersSporadic Parkinson'S Diseasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objectives: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. Methods: We administered executive, semantic, verb-production, and syntactic tasks to sporadic PD patients, genetic PD patients with PARK2 (parkin) or LRRK2 (dardarin) mutation, asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls. Moreover, to detect sui generis language disturbances, we ran analysis of covariance tests using executive functions as covariate. Results: The two clinical groups showed impairments in all measures, most of which survived covariation with executive functions. However, the key finding concerned asymptomatic mutation carriers. While these subjects showed intact executive, semantic, and action-verb production skills, they evinced deficits in a syntactic test with minimal working memory load. Conclusions: We propose that this sui generis disturbance may constitute a prodromal sign anticipating eventual development of PD. Moreover, our results suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms.Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Trujillo, Natalia. Universidad de Antioquia; ColombiaFil: Bocanegra, Yamile. Universidad de Antioquia; ColombiaFil: Gomez, Diana. Universidad de Antioquia; ColombiaFil: Pineda, David. Universidad de Antioquia; ColombiaFil: Villegas, Andrés. Universidad de Antioquia; ColombiaFil: Muñoz, Edinson. Universidad de Santiago de Chile; ChileFil: Arias, William. Universidad de Antioquia; ColombiaFil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Macquarie University; AustraliaCambridge University Press2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66502García, Adolfo Martín; Sedeño, Lucas; Trujillo, Natalia; Bocanegra, Yamile; Gomez, Diana; et al.; Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers; Cambridge University Press; Journal of the International Neuropsychological Society : Jins; 23; 2; 2-2017; 150-1581355-6177CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/language-deficits-as-a-preclinical-window-into-parkinsons-disease-evidence-from-asymptomatic-parkin-and-dardarin-mutation-carriers/6C22AB82F0021384939B330267742C7Finfo:eu-repo/semantics/altIdentifier/doi/10.1017/S1355617716000710info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:08Zoai:ri.conicet.gov.ar:11336/66502instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:08.537CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers
title Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers
spellingShingle Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers
García, Adolfo Martín
Genetic Parkinson'S Disease
Language
Lrrk2
Park2
Preclinical Mutation Carriers
Sporadic Parkinson'S Disease
title_short Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers
title_full Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers
title_fullStr Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers
title_full_unstemmed Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers
title_sort Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers
dc.creator.none.fl_str_mv García, Adolfo Martín
Sedeño, Lucas
Trujillo, Natalia
Bocanegra, Yamile
Gomez, Diana
Pineda, David
Villegas, Andrés
Muñoz, Edinson
Arias, William
Ibañez, Agustin Mariano
author García, Adolfo Martín
author_facet García, Adolfo Martín
Sedeño, Lucas
Trujillo, Natalia
Bocanegra, Yamile
Gomez, Diana
Pineda, David
Villegas, Andrés
Muñoz, Edinson
Arias, William
Ibañez, Agustin Mariano
author_role author
author2 Sedeño, Lucas
Trujillo, Natalia
Bocanegra, Yamile
Gomez, Diana
Pineda, David
Villegas, Andrés
Muñoz, Edinson
Arias, William
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genetic Parkinson'S Disease
Language
Lrrk2
Park2
Preclinical Mutation Carriers
Sporadic Parkinson'S Disease
topic Genetic Parkinson'S Disease
Language
Lrrk2
Park2
Preclinical Mutation Carriers
Sporadic Parkinson'S Disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. Methods: We administered executive, semantic, verb-production, and syntactic tasks to sporadic PD patients, genetic PD patients with PARK2 (parkin) or LRRK2 (dardarin) mutation, asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls. Moreover, to detect sui generis language disturbances, we ran analysis of covariance tests using executive functions as covariate. Results: The two clinical groups showed impairments in all measures, most of which survived covariation with executive functions. However, the key finding concerned asymptomatic mutation carriers. While these subjects showed intact executive, semantic, and action-verb production skills, they evinced deficits in a syntactic test with minimal working memory load. Conclusions: We propose that this sui generis disturbance may constitute a prodromal sign anticipating eventual development of PD. Moreover, our results suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms.
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Trujillo, Natalia. Universidad de Antioquia; Colombia
Fil: Bocanegra, Yamile. Universidad de Antioquia; Colombia
Fil: Gomez, Diana. Universidad de Antioquia; Colombia
Fil: Pineda, David. Universidad de Antioquia; Colombia
Fil: Villegas, Andrés. Universidad de Antioquia; Colombia
Fil: Muñoz, Edinson. Universidad de Santiago de Chile; Chile
Fil: Arias, William. Universidad de Antioquia; Colombia
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Macquarie University; Australia
description Objectives: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. Methods: We administered executive, semantic, verb-production, and syntactic tasks to sporadic PD patients, genetic PD patients with PARK2 (parkin) or LRRK2 (dardarin) mutation, asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls. Moreover, to detect sui generis language disturbances, we ran analysis of covariance tests using executive functions as covariate. Results: The two clinical groups showed impairments in all measures, most of which survived covariation with executive functions. However, the key finding concerned asymptomatic mutation carriers. While these subjects showed intact executive, semantic, and action-verb production skills, they evinced deficits in a syntactic test with minimal working memory load. Conclusions: We propose that this sui generis disturbance may constitute a prodromal sign anticipating eventual development of PD. Moreover, our results suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66502
García, Adolfo Martín; Sedeño, Lucas; Trujillo, Natalia; Bocanegra, Yamile; Gomez, Diana; et al.; Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers; Cambridge University Press; Journal of the International Neuropsychological Society : Jins; 23; 2; 2-2017; 150-158
1355-6177
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66502
identifier_str_mv García, Adolfo Martín; Sedeño, Lucas; Trujillo, Natalia; Bocanegra, Yamile; Gomez, Diana; et al.; Language Deficits as a Preclinical Window into Parkinson's Disease: Evidence from Asymptomatic Parkin and Dardarin Mutation Carriers; Cambridge University Press; Journal of the International Neuropsychological Society : Jins; 23; 2; 2-2017; 150-158
1355-6177
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/language-deficits-as-a-preclinical-window-into-parkinsons-disease-evidence-from-asymptomatic-parkin-and-dardarin-mutation-carriers/6C22AB82F0021384939B330267742C7F
info:eu-repo/semantics/altIdentifier/doi/10.1017/S1355617716000710
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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