Testosterona, emoción y cognición: estudios en animales castrados
- Autores
- Justel, Nadia; Bentosela, Mariana; Ruetti, Eliana Martha
- Año de publicación
- 2010
- Idioma
- español castellano
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Se informa una revisión de las principales investigaciones referidas al efecto de la depleción de las hormonas sexuales, mediante la gonadectomía, sobre el comportamiento de ratas macho adultas. Esta revisión se divide en dos grandes áreas: por un lado, se describen las líneas de investigación acerca del efecto de la castración sobre la emoción y por otro, se discuten los aportes relevantes relacionados con el efecto de la depleción de testosterona sobre la cognición. Los resultados de distintas investigaciones y métodos empleados sugieren que la depleción de testosterona tiende a provocar mayor ansiedad, disminuir los umbrales de dolor y a producir mayores respuestas de tipo depresivas. El reemplazo con testosterona puede revertir estos efectos. Los trabajos acerca de los efectos cognitivos señalan que existe una relación compleja y ambigua entre los andrógenos y la cognición. Algunos trabajos muestran efectos deletéreos cuando los animales sufren una depleción de testosterona; varios de ellos pueden ser revertidos con la administración de hormonas sexuales.
Sexual behavior is a very important part in the life of animals, and sexual hormones, such as estrogen in females and testosterone in males, regulate the behavior of most mammals. Testosterone, the male sexual hormone, plays an important role in the development of the brain organization necessary for sexual behavior. Some evidences show that testosterone affects animal behavior and has an anxiolytic as well as analgesic effects on the behavior of rats, mice, dogs, and humans. For example, men who have higher endogenous levels of testosterone have a lower incidence of depression. Conversely, young hypogonad men, with low endogenous testosterone, are more likely to be diagnosed with anxiety or depressive disorders, and exhibit decreased performance in some cognitive tasks. In animal models of androgen deficiency, androgens can mediate both, affective and cognitive behavior. Removing rats primary source of endogenous androgens through androgen extirpation (i.e., castration or gonadectomy) results in increased anxiety-like behavior, and detriments in cognitive performance. In the present paper, we review the main research on the effect of sexual hormone depletion, through gonadectomy, on the behavior of adult male rats. There are different ways to study the influence of testosterone on emotion and cognition, the study of the sexual behavior, the study of the administration of testosterone and their metabolites and the effect of the depletion of testosterone. This review is arranged in two main sections: on the one hand, we describe studies about castration effects on animal emotion; on the other hand, we discuss most relevant contributions linked to the effect of testosterone depletion on cognition. To finish, there is a section where we explain the neurobiological mechanisms involved in emotion and cognition of animals with hormone depletion. Data suggests that testosterone modulates emotion, in particular anxiety, fear, pain, and depression responses. Results from different investigations using diverse methodologies suggest that testosterone depletion tends to cause higher anxiety and depressive-like responses and to lower pain thresholds; some of the tests used to evaluated emotion are: open field test, elevated plus maze, defensive burying, Vogel's paradigm, tail flick, hot plate, among others. In addition, testosterone replacement can reverse these effects in male rodents in some of these tests. Studies on the cognitive consequences of hormones point towards the existence of a complex and ambiguous relationship between androgens and cognition. Some studies show deleterious effects when animals are subjected to testosterone deletion, most of which can be reverted with sexual hormones administration, for example in the defensive freezing to electric shocks. However, there are several studies showing that gonadectomy does not always cause a performance deficit, and that the deficit may appear depending on certain variables of the studied tasks, in particular the time intervals among stimuli, for example in radial maze. More specifically, performance deteriorates when working memory is evaluated. To finish, we review the neurobiological mechanisms involved in the effect of gonadectomy on behavior. Similar findings occur when either emotion or cognition is assessed, though studies on this last area are scarcer. Data suggest that testosterone metabolism is the effective component in anxiety reduction and increased cognitive performance. In particular, evidence indicates that androgen and estrogen receptors would be involved in this phenomenon, and that these effects could be blocked through the administration of antagonist drugs. Last, it is important to stress that the relationship between testosterone and both emotion and cognition is extremely complex. There is no doubt that the gonads affect animal and human existence and thus more research is needed to continue studying and clarifying these relationships which play an important role in our existence.
Fil: Justel, Nadia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Bentosela, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ruetti, Eliana Martha. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Testosterona
Emoción
Cognición
Castración - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/15357
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Testosterona, emoción y cognición: estudios en animales castradosTestosterone, emotion and cognition: castrated animals studiesJustel, NadiaBentosela, MarianaRuetti, Eliana MarthaTestosteronaEmociónCogniciónCastraciónhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Se informa una revisión de las principales investigaciones referidas al efecto de la depleción de las hormonas sexuales, mediante la gonadectomía, sobre el comportamiento de ratas macho adultas. Esta revisión se divide en dos grandes áreas: por un lado, se describen las líneas de investigación acerca del efecto de la castración sobre la emoción y por otro, se discuten los aportes relevantes relacionados con el efecto de la depleción de testosterona sobre la cognición. Los resultados de distintas investigaciones y métodos empleados sugieren que la depleción de testosterona tiende a provocar mayor ansiedad, disminuir los umbrales de dolor y a producir mayores respuestas de tipo depresivas. El reemplazo con testosterona puede revertir estos efectos. Los trabajos acerca de los efectos cognitivos señalan que existe una relación compleja y ambigua entre los andrógenos y la cognición. Algunos trabajos muestran efectos deletéreos cuando los animales sufren una depleción de testosterona; varios de ellos pueden ser revertidos con la administración de hormonas sexuales.Sexual behavior is a very important part in the life of animals, and sexual hormones, such as estrogen in females and testosterone in males, regulate the behavior of most mammals. Testosterone, the male sexual hormone, plays an important role in the development of the brain organization necessary for sexual behavior. Some evidences show that testosterone affects animal behavior and has an anxiolytic as well as analgesic effects on the behavior of rats, mice, dogs, and humans. For example, men who have higher endogenous levels of testosterone have a lower incidence of depression. Conversely, young hypogonad men, with low endogenous testosterone, are more likely to be diagnosed with anxiety or depressive disorders, and exhibit decreased performance in some cognitive tasks. In animal models of androgen deficiency, androgens can mediate both, affective and cognitive behavior. Removing rats primary source of endogenous androgens through androgen extirpation (i.e., castration or gonadectomy) results in increased anxiety-like behavior, and detriments in cognitive performance. In the present paper, we review the main research on the effect of sexual hormone depletion, through gonadectomy, on the behavior of adult male rats. There are different ways to study the influence of testosterone on emotion and cognition, the study of the sexual behavior, the study of the administration of testosterone and their metabolites and the effect of the depletion of testosterone. This review is arranged in two main sections: on the one hand, we describe studies about castration effects on animal emotion; on the other hand, we discuss most relevant contributions linked to the effect of testosterone depletion on cognition. To finish, there is a section where we explain the neurobiological mechanisms involved in emotion and cognition of animals with hormone depletion. Data suggests that testosterone modulates emotion, in particular anxiety, fear, pain, and depression responses. Results from different investigations using diverse methodologies suggest that testosterone depletion tends to cause higher anxiety and depressive-like responses and to lower pain thresholds; some of the tests used to evaluated emotion are: open field test, elevated plus maze, defensive burying, Vogel's paradigm, tail flick, hot plate, among others. In addition, testosterone replacement can reverse these effects in male rodents in some of these tests. Studies on the cognitive consequences of hormones point towards the existence of a complex and ambiguous relationship between androgens and cognition. Some studies show deleterious effects when animals are subjected to testosterone deletion, most of which can be reverted with sexual hormones administration, for example in the defensive freezing to electric shocks. However, there are several studies showing that gonadectomy does not always cause a performance deficit, and that the deficit may appear depending on certain variables of the studied tasks, in particular the time intervals among stimuli, for example in radial maze. More specifically, performance deteriorates when working memory is evaluated. To finish, we review the neurobiological mechanisms involved in the effect of gonadectomy on behavior. Similar findings occur when either emotion or cognition is assessed, though studies on this last area are scarcer. Data suggest that testosterone metabolism is the effective component in anxiety reduction and increased cognitive performance. In particular, evidence indicates that androgen and estrogen receptors would be involved in this phenomenon, and that these effects could be blocked through the administration of antagonist drugs. Last, it is important to stress that the relationship between testosterone and both emotion and cognition is extremely complex. There is no doubt that the gonads affect animal and human existence and thus more research is needed to continue studying and clarifying these relationships which play an important role in our existence.Fil: Justel, Nadia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Bentosela, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ruetti, Eliana Martha. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15357Justel, Nadia; Bentosela, Mariana; Ruetti, Eliana Martha; Testosterona, emoción y cognición: estudios en animales castrados; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. 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dc.title.none.fl_str_mv |
Testosterona, emoción y cognición: estudios en animales castrados Testosterone, emotion and cognition: castrated animals studies |
title |
Testosterona, emoción y cognición: estudios en animales castrados |
spellingShingle |
Testosterona, emoción y cognición: estudios en animales castrados Justel, Nadia Testosterona Emoción Cognición Castración |
title_short |
Testosterona, emoción y cognición: estudios en animales castrados |
title_full |
Testosterona, emoción y cognición: estudios en animales castrados |
title_fullStr |
Testosterona, emoción y cognición: estudios en animales castrados |
title_full_unstemmed |
Testosterona, emoción y cognición: estudios en animales castrados |
title_sort |
Testosterona, emoción y cognición: estudios en animales castrados |
dc.creator.none.fl_str_mv |
Justel, Nadia Bentosela, Mariana Ruetti, Eliana Martha |
author |
Justel, Nadia |
author_facet |
Justel, Nadia Bentosela, Mariana Ruetti, Eliana Martha |
author_role |
author |
author2 |
Bentosela, Mariana Ruetti, Eliana Martha |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Testosterona Emoción Cognición Castración |
topic |
Testosterona Emoción Cognición Castración |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/5.1 https://purl.org/becyt/ford/5 |
dc.description.none.fl_txt_mv |
Se informa una revisión de las principales investigaciones referidas al efecto de la depleción de las hormonas sexuales, mediante la gonadectomía, sobre el comportamiento de ratas macho adultas. Esta revisión se divide en dos grandes áreas: por un lado, se describen las líneas de investigación acerca del efecto de la castración sobre la emoción y por otro, se discuten los aportes relevantes relacionados con el efecto de la depleción de testosterona sobre la cognición. Los resultados de distintas investigaciones y métodos empleados sugieren que la depleción de testosterona tiende a provocar mayor ansiedad, disminuir los umbrales de dolor y a producir mayores respuestas de tipo depresivas. El reemplazo con testosterona puede revertir estos efectos. Los trabajos acerca de los efectos cognitivos señalan que existe una relación compleja y ambigua entre los andrógenos y la cognición. Algunos trabajos muestran efectos deletéreos cuando los animales sufren una depleción de testosterona; varios de ellos pueden ser revertidos con la administración de hormonas sexuales. Sexual behavior is a very important part in the life of animals, and sexual hormones, such as estrogen in females and testosterone in males, regulate the behavior of most mammals. Testosterone, the male sexual hormone, plays an important role in the development of the brain organization necessary for sexual behavior. Some evidences show that testosterone affects animal behavior and has an anxiolytic as well as analgesic effects on the behavior of rats, mice, dogs, and humans. For example, men who have higher endogenous levels of testosterone have a lower incidence of depression. Conversely, young hypogonad men, with low endogenous testosterone, are more likely to be diagnosed with anxiety or depressive disorders, and exhibit decreased performance in some cognitive tasks. In animal models of androgen deficiency, androgens can mediate both, affective and cognitive behavior. Removing rats primary source of endogenous androgens through androgen extirpation (i.e., castration or gonadectomy) results in increased anxiety-like behavior, and detriments in cognitive performance. In the present paper, we review the main research on the effect of sexual hormone depletion, through gonadectomy, on the behavior of adult male rats. There are different ways to study the influence of testosterone on emotion and cognition, the study of the sexual behavior, the study of the administration of testosterone and their metabolites and the effect of the depletion of testosterone. This review is arranged in two main sections: on the one hand, we describe studies about castration effects on animal emotion; on the other hand, we discuss most relevant contributions linked to the effect of testosterone depletion on cognition. To finish, there is a section where we explain the neurobiological mechanisms involved in emotion and cognition of animals with hormone depletion. Data suggests that testosterone modulates emotion, in particular anxiety, fear, pain, and depression responses. Results from different investigations using diverse methodologies suggest that testosterone depletion tends to cause higher anxiety and depressive-like responses and to lower pain thresholds; some of the tests used to evaluated emotion are: open field test, elevated plus maze, defensive burying, Vogel's paradigm, tail flick, hot plate, among others. In addition, testosterone replacement can reverse these effects in male rodents in some of these tests. Studies on the cognitive consequences of hormones point towards the existence of a complex and ambiguous relationship between androgens and cognition. Some studies show deleterious effects when animals are subjected to testosterone deletion, most of which can be reverted with sexual hormones administration, for example in the defensive freezing to electric shocks. However, there are several studies showing that gonadectomy does not always cause a performance deficit, and that the deficit may appear depending on certain variables of the studied tasks, in particular the time intervals among stimuli, for example in radial maze. More specifically, performance deteriorates when working memory is evaluated. To finish, we review the neurobiological mechanisms involved in the effect of gonadectomy on behavior. Similar findings occur when either emotion or cognition is assessed, though studies on this last area are scarcer. Data suggest that testosterone metabolism is the effective component in anxiety reduction and increased cognitive performance. In particular, evidence indicates that androgen and estrogen receptors would be involved in this phenomenon, and that these effects could be blocked through the administration of antagonist drugs. Last, it is important to stress that the relationship between testosterone and both emotion and cognition is extremely complex. There is no doubt that the gonads affect animal and human existence and thus more research is needed to continue studying and clarifying these relationships which play an important role in our existence. Fil: Justel, Nadia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina Fil: Bentosela, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ruetti, Eliana Martha. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Se informa una revisión de las principales investigaciones referidas al efecto de la depleción de las hormonas sexuales, mediante la gonadectomía, sobre el comportamiento de ratas macho adultas. Esta revisión se divide en dos grandes áreas: por un lado, se describen las líneas de investigación acerca del efecto de la castración sobre la emoción y por otro, se discuten los aportes relevantes relacionados con el efecto de la depleción de testosterona sobre la cognición. Los resultados de distintas investigaciones y métodos empleados sugieren que la depleción de testosterona tiende a provocar mayor ansiedad, disminuir los umbrales de dolor y a producir mayores respuestas de tipo depresivas. El reemplazo con testosterona puede revertir estos efectos. Los trabajos acerca de los efectos cognitivos señalan que existe una relación compleja y ambigua entre los andrógenos y la cognición. Algunos trabajos muestran efectos deletéreos cuando los animales sufren una depleción de testosterona; varios de ellos pueden ser revertidos con la administración de hormonas sexuales. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/15357 Justel, Nadia; Bentosela, Mariana; Ruetti, Eliana Martha; Testosterona, emoción y cognición: estudios en animales castrados; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental; Interdisciplinaria; 27; 2; 12-2010; 191-208 0325-8203 1668-7027 |
url |
http://hdl.handle.net/11336/15357 |
identifier_str_mv |
Justel, Nadia; Bentosela, Mariana; Ruetti, Eliana Martha; Testosterona, emoción y cognición: estudios en animales castrados; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental; Interdisciplinaria; 27; 2; 12-2010; 191-208 0325-8203 1668-7027 |
dc.language.none.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/4pc9xt info:eu-repo/semantics/altIdentifier/url/http://www.redalyc.org/pdf/180/18018446001.pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
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application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental |
publisher.none.fl_str_mv |
Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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