Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study

Autores
Bigliani, María Celeste; Rosso, María Celeste; Zunino, María Paula; Baiardi, Gustavo Carlos; Ponce, Andrés Alberto
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of this study was to examine the effect of orally administered Uncaria tomentosa aqueous extracts (UTE) (Willd. ex Roem. & Schult.) DC. (Rubiaceae) during 7, 15, 30 and 90 days of treatment on the expression of anxiety, as expressed in the elevated plus maze test in male Albino Swiss mice. UTE revealed an anxiogenic effect in relation to the control group at 15 and 30 days, but it was reversed after 90 days of administration, without affecting the locomotor activity or any deleterious effects on the overall performance of the animal, either for its ambulation, or clinical status, and body weight and organ weight/body weight from liver, lung and kidney were unaffected. These biphasic effects are usually indicative of heterogeneity in sites of action due to the presence of many alkaloids (speciophylline, uncarine F and uncarine E) and flavanols (catechin and epigallocatechin) identified and isolated from UTE.
Fil: Bigliani, María Celeste. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisiologia Humana; Argentina
Fil: Rosso, María Celeste. Universidad Nacional de la Rioja; Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Baiardi, Gustavo Carlos. Universidad Catolica de Cordoba. Facultad de Cs.quimicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ponce, Andrés Alberto. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisiologia Humana; Argentina. Universidad Nacional de la Rioja; Argentina
Materia
Uncaria Tomentosa
Plus Maze
Rodent
Anxiety Test
Behavioural
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12608
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary studyBigliani, María CelesteRosso, María CelesteZunino, María PaulaBaiardi, Gustavo CarlosPonce, Andrés AlbertoUncaria TomentosaPlus MazeRodentAnxiety TestBehaviouralhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The purpose of this study was to examine the effect of orally administered Uncaria tomentosa aqueous extracts (UTE) (Willd. ex Roem. & Schult.) DC. (Rubiaceae) during 7, 15, 30 and 90 days of treatment on the expression of anxiety, as expressed in the elevated plus maze test in male Albino Swiss mice. UTE revealed an anxiogenic effect in relation to the control group at 15 and 30 days, but it was reversed after 90 days of administration, without affecting the locomotor activity or any deleterious effects on the overall performance of the animal, either for its ambulation, or clinical status, and body weight and organ weight/body weight from liver, lung and kidney were unaffected. These biphasic effects are usually indicative of heterogeneity in sites of action due to the presence of many alkaloids (speciophylline, uncarine F and uncarine E) and flavanols (catechin and epigallocatechin) identified and isolated from UTE.Fil: Bigliani, María Celeste. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisiologia Humana; ArgentinaFil: Rosso, María Celeste. Universidad Nacional de la Rioja; ArgentinaFil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Baiardi, Gustavo Carlos. Universidad Catolica de Cordoba. Facultad de Cs.quimicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ponce, Andrés Alberto. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisiologia Humana; Argentina. Universidad Nacional de la Rioja; ArgentinaTaylor & Francis2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12608Bigliani, María Celeste; Rosso, María Celeste; Zunino, María Paula; Baiardi, Gustavo Carlos; Ponce, Andrés Alberto; Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study; Taylor & Francis; Natural Product Research; 27; 18; 1-2013; 1682-16851478-64191478-6427enginfo:eu-repo/semantics/altIdentifier/doi/10.1080/14786419.2012.761617info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/14786419.2012.761617info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:11Zoai:ri.conicet.gov.ar:11336/12608instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:12.441CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
title Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
spellingShingle Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
Bigliani, María Celeste
Uncaria Tomentosa
Plus Maze
Rodent
Anxiety Test
Behavioural
title_short Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
title_full Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
title_fullStr Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
title_full_unstemmed Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
title_sort Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study
dc.creator.none.fl_str_mv Bigliani, María Celeste
Rosso, María Celeste
Zunino, María Paula
Baiardi, Gustavo Carlos
Ponce, Andrés Alberto
author Bigliani, María Celeste
author_facet Bigliani, María Celeste
Rosso, María Celeste
Zunino, María Paula
Baiardi, Gustavo Carlos
Ponce, Andrés Alberto
author_role author
author2 Rosso, María Celeste
Zunino, María Paula
Baiardi, Gustavo Carlos
Ponce, Andrés Alberto
author2_role author
author
author
author
dc.subject.none.fl_str_mv Uncaria Tomentosa
Plus Maze
Rodent
Anxiety Test
Behavioural
topic Uncaria Tomentosa
Plus Maze
Rodent
Anxiety Test
Behavioural
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The purpose of this study was to examine the effect of orally administered Uncaria tomentosa aqueous extracts (UTE) (Willd. ex Roem. & Schult.) DC. (Rubiaceae) during 7, 15, 30 and 90 days of treatment on the expression of anxiety, as expressed in the elevated plus maze test in male Albino Swiss mice. UTE revealed an anxiogenic effect in relation to the control group at 15 and 30 days, but it was reversed after 90 days of administration, without affecting the locomotor activity or any deleterious effects on the overall performance of the animal, either for its ambulation, or clinical status, and body weight and organ weight/body weight from liver, lung and kidney were unaffected. These biphasic effects are usually indicative of heterogeneity in sites of action due to the presence of many alkaloids (speciophylline, uncarine F and uncarine E) and flavanols (catechin and epigallocatechin) identified and isolated from UTE.
Fil: Bigliani, María Celeste. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisiologia Humana; Argentina
Fil: Rosso, María Celeste. Universidad Nacional de la Rioja; Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Baiardi, Gustavo Carlos. Universidad Catolica de Cordoba. Facultad de Cs.quimicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ponce, Andrés Alberto. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Fisiologia Humana y Fisica Biomedica. Catedra de Fisiologia Humana; Argentina. Universidad Nacional de la Rioja; Argentina
description The purpose of this study was to examine the effect of orally administered Uncaria tomentosa aqueous extracts (UTE) (Willd. ex Roem. & Schult.) DC. (Rubiaceae) during 7, 15, 30 and 90 days of treatment on the expression of anxiety, as expressed in the elevated plus maze test in male Albino Swiss mice. UTE revealed an anxiogenic effect in relation to the control group at 15 and 30 days, but it was reversed after 90 days of administration, without affecting the locomotor activity or any deleterious effects on the overall performance of the animal, either for its ambulation, or clinical status, and body weight and organ weight/body weight from liver, lung and kidney were unaffected. These biphasic effects are usually indicative of heterogeneity in sites of action due to the presence of many alkaloids (speciophylline, uncarine F and uncarine E) and flavanols (catechin and epigallocatechin) identified and isolated from UTE.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12608
Bigliani, María Celeste; Rosso, María Celeste; Zunino, María Paula; Baiardi, Gustavo Carlos; Ponce, Andrés Alberto; Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study; Taylor & Francis; Natural Product Research; 27; 18; 1-2013; 1682-1685
1478-6419
1478-6427
url http://hdl.handle.net/11336/12608
identifier_str_mv Bigliani, María Celeste; Rosso, María Celeste; Zunino, María Paula; Baiardi, Gustavo Carlos; Ponce, Andrés Alberto; Anxiogenic-like effects of Uncaria tomentosa (Willd) DC aqueous extract in an elevated plus-maze test in mice: a preliminary study; Taylor & Francis; Natural Product Research; 27; 18; 1-2013; 1682-1685
1478-6419
1478-6427
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/14786419.2012.761617
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/14786419.2012.761617
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268649762586624
score 13.13397

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